As the population ages the incidence of neurodegenerative diseases is increasing, and with no effect treatments, they represent a major public health problem. Advances in human genetics and the identification of risk genes have allowed the application of modern molecular biological and genomic tools to study disease mechanisms. These studies have revealed the importance of immune mechanisms, RNA metabolism, lysosomal biology and autophagy in disease risk. The 2020 Gordon Conference on Neurobiology of Brain Disorders will bring together leaders in basic, clinical and translational research to discuss their latest findings and novel concepts. Invited speakers represent a wide variety of scientific disciplines including genetics, genomics, systems biology, cell biology, disease modeling in cells and animals, biomarker discovery and therapeutic development. The conference will also provide a platform for junior scientists and graduate students to present their work and to interact informally with leaders in the field.