Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"ARPP21 and ALS: Putative Link Between Excitotoxicity and TDP-43 Proteinopathy"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Antisense Oligonucleotide Depletion of CCDC146 is a Broad-Spectrum Therapeutic Strategy for ALS"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Silence ALS: A Platform for Precision Medicine in ALS"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Drugging the Undruggable - Precision Gene Therapy Targeting Cav1.3 Channels in Parkinson's Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Advancing Personalized Gene Editing Therapies for Rare Genetic Diseases"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transformative Neuropathology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Modernizing Neuropathology in the Study of Alzheimer’s Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
"When One Target Isn’t Enough: Rethinking Neurodegeneration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"TDP-43 Dysfunction and Immune Response in AD"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"21st Century Brain Banking Supporting Novel Technologies"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Short Talk Selected from Poster Abstracts
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genetic Drivers of Neurodegeneration
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:25 pm
"Novel Insights into the Genomics of Dementia from Latin American Admixed Populations"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Scaling Therapeutic Manipulation of the ALS Mutome"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Human Endogenous Retrovirus K RNA Triggers Cytoplasmic TDP-43 Aggregation by Initiating Pathological Nuclear Condensates"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Identification of Novel Therapeutic Targets Using Human Genetics"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Interactions Between Tau Fibrilization and RNP Granules"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Links to Metabolism, Lipid Biology and the Vasculature
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"From VCID Molecular Signatures to Mechanisms of Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"The Intersection of Guanosine Nucleotide Metabolism and Bioenergetics is a PD Susceptibility Locus"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Decoding Cholesterol-mTORC1 Signaling in Neuronal Homeostasis and Disease"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Lysosome Lipid Catabolism and Neurodegeneration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Leveraging a Transferrin Receptor-Based Transport Vehicle for Protein Replacement Therapy in GRN-Associated Frontotemporal Dementia"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Vascular Dementia Progression: Vascular-Immune Interactions"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Insights from Structural Biology
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:25 pm
"Molecular Drivers and Protective Mechanisms in TDP-43 Pathology"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Bringing Structure to Pathological Protein Assembly in Neurodegenerative Diseases"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Molecular Visualization of Pathological Protein Aggregates In Situ "
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Single Cells to Clinical Applications - Proteomics in Neurodegenerative Diseases"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Model Systems of Tauopathies that Recapitulate Disease-Specific Structures of Tau Filaments"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Architecture of Synapse Diversity in Health and Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
"TDP-43 Proteinopathy: Is It All About Activity?"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Building Advanced Neuromuscular Models to Study ALS"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"X Chromosomes, Brain Aging and Alzheimer’s Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Disruption of Protein Homeostasis Impairs Sleep Architecture in Mouse Models of Huntington’s Disease"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Next Generation Functional Genomics
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:25 pm
"High Content Functional Genomics in CNS Cell Models"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Uncovering Mechanisms of Neuron and Synapse Loss through Unbiased CRISPR Screens"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Pharmacological and Genetic Screens Identify Regulators of TDP-43 and FUS Localization and Function"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"TDP-43 Dysfunction Leads to the Generation of Cryptic Splice Products Fusing Genes and Transposable Elements (CrypTEs) in iNeurons and ALS Cortical Tissues"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"TDP-43 Gain of Function Impacts Splicing in Multiple Neurodegenerative Diseases"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Glial Cells and Neuroinflammation
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Single-Cell Spatial Mapping of Aged Hippocampal Niches in Mice and Humans"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Role of APOE and the Immune Response in Tauopathy"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Immune Response to Cerebral Amyloid Angiopathy"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Glia in Brain-Body Communication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Novel Functions of Oligodendrocytes in Energy, Metabolism and Alzheimer’s Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Short Talk Selected from Poster Abstracts
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Deep Phenotyping and Next Generation Trial Design
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:25 pm
"Advances in Tau Therapeutic Development for Common and Rare Tauopathies"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Unravelling the Heterogeneity of ALS to Enable Biomarker-Driven Pathomechanistic Patient Stratification"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Personalised Clinical Trials – Do They Make Sense in ALS?"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Prevention Trials for ALS and FTD: The Role of Clinical Markers and Biomarkers"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Late-Breaking Topic
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure