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Saturday
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| 1:30 pm - 4:30 pm |
Arrival and Check-in
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| 3:00 pm - 3:15 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:15 pm - 4:00 pm |
Protein Processing, Aggregation and Toxicity
Discussion Leader: Tien-Phat Huynh (Washington University School of Medicine, USA)
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| 3:15 pm - 3:20 pm |
Opening Remarks
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| 3:20 pm - 3:35 pm |
Maria Szaruga (VIB, KU Leuven, Belgium)
"Molecular Mechanisms Underlying Familial Alzheimer's Disease, Providing the Basis for Novel Drug Discovery Strategies"
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| 3:35 pm - 3:40 pm |
Discussion
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| 3:40 pm - 3:55 pm |
Olga Zolochevska (University of Texas Medical Branch, USA)
"Epigenetic Modulation of Synaptic Resilience in Alzheimer's Disease"
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| 3:55 pm - 4:00 pm |
Discussion
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| 4:00 pm - 5:30 pm |
Poster Session
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| 5:30 pm - 7:30 pm |
Cellular and Subcellular Mechanisms of Neurodegeneration
Discussion Leader: Kriti Chaplot (Indian Institute of Science Education and Research (IISER), India)
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| 5:30 pm - 5:50 pm |
Enrico Bagnoli (CURAM, National University of Ireland Galway, Ireland)
"DOPAL-Treated Olfactory Bulb Organotypic Slices as a Model of Prodromal Parkinson's Disease"
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| 5:50 pm - 6:00 pm |
Discussion
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| 6:00 pm - 6:20 pm |
Stephanie Kyle (Emory University, USA)
"Using a Novel LSD1-Mediated Model of Neurodegeneration to Study the Molecular Mechanism of Alzheimer's Disease"
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| 6:20 pm - 6:30 pm |
Discussion
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| 6:30 pm - 6:50 pm |
Eileen Ruth Torres (Oregon Health & Science University, USA)
"Apolipoprotein E Isoform-Specific Effects on Cortical Oxysterols in Mice"
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| 6:50 pm - 7:00 pm |
Discussion
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| 7:00 pm - 7:20 pm |
Elisa Navarro (Icahn School of Medicine at Mount Sinai, USA)
"Trans-Regulation of Gene Expression in Human Monocytes and Macrophages Implicate the Lysosomal Pathway in the Pathogenesis of Parkinson's Disease"
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| 7:20 pm - 7:30 pm |
Discussion
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| 8:00 pm - 9:00 pm |
Dinner
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
Glia and Neuroinflammation
Discussion Leader: Jessica Rexach (UCLA Neurology, USA)
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| 9:00 am - 9:20 am |
Emily Button (University of British Columbia, Canada)
"Pharmacological and Genetic Manipulation of Lipoprotein Metabolism Alters Neuroinflammation in APP/PS1 Mice"
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| 9:20 am - 9:30 am |
Discussion
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| 9:30 am - 9:50 am |
Brian Lananna (Washington University in St. Louis, USA)
"The Astrocytic Circadian Clock Gates Neuroinflammation and Neuronal Health Through Regulation of Alzheimer's Disease Biomarker Chi3l1 (YKL-40)"
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| 9:50 am - 10:00 am |
Discussion
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| 10:00 am - 10:20 am |
Hazel Hall-Roberts (University of Oxford, United Kingdom)
"Phenotypic Studies of the R47H Alzheimer's Disease Mutation of TREM2 Using Human iPSC-Macrophages"
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| 10:20 am - 10:30 am |
Discussion
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| 10:30 am - 10:50 am |
Alexandre Trotier (National University of Ireland Galway, Ireland)
"Mechanically Induced Neuroinflammation to Reproduce Peri-Electrode Gliosis Macro Environment"
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| 10:50 am - 11:00 am |
Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: Career Panel
An interactive Q&A session with a panel of leaders in the field.
Discussion Leaders: Peter Chung (University of Chicago, USA) and Heather Rice (VIB & KU Leuven Center for Brain & Disease Research, Belgium)
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| 1:30 pm - 2:30 pm |
Panel Discussion
Career Paths and Experiences
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Cheryl Wellington (University of British Columbia, Canada)
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Andrew Yoo (Washington University School of Medicine, USA)
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Judith Steen (Harvard Medical School, USA)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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