Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Critical Lessons of the Past and Their Application to Modern Antibacterial Drug Discovery and Development
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:40 pm
"Scaffold Complexity Generation by Tailoring Enzymes in Natural Product Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Development and Approval Pathway for Ceftazidime-Avibactam: A Step Towards Tailoring Programs to Address Antibiotic Resistance"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Clinical Reality – Single Agent Therapeutics and Antibacterial Drug Resistance: Examining the Need for New Therapeutic Options in the Clinic
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Pushing the Envelope: Multi-Resistance in Gram-Negative Bacteria"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Diagnostics for Single Pathogen Drugs"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Emergence of Antibiotic Resistance in the Immune-Compromised"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Clostridium difficile Infection: Drug Resistance Concerns Mandate the Need for Targeted Therapeutics"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Kinetic and Molecular Determinants of Antibiotic Permeation Barriers"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"SPARK: Pew's Shared Platform for Antibiotic Research and Knowledge"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Twenty First Century Natural Product-Based Antibiotic Discovery
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mining Genomes for Antibiotics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Harnessing Genomic Information to Engineer the Biosynthesis of Novel Antibiotics with Novel MOA"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Molecular Phylogentics to Guide New Natural Product Discovery"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Bioinformatics and Chemistry Join Forces for Antibiotics Discovery"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gram-Negative Outer Membrane Biogenesis – Targeting Antibiotic Barrier
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Characterizing the Machine that Builds the Outer Membrane"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Understanding LPS Transport"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
"High Resolution Views of Lipopolysaccharide Transport Revealed by Cryo-EM"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
"Chemical Inhibitor of an Essential Stress Response Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Widening the Therapeutic Window of LpxC Inhibitors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Inhibition of the LPS ABC Transporter MsbA as a Novel Antibacterial Strategy for Gram-Negative Pathogens"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Re-Examining Chemical Design Strategies for Antibacterial Agents
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Predictive Guidelines for Compound Accumulation Lead to New Broad-Spectrum Antibiotics"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Drug-Target Kinetics and Antibacterial Efficacy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The Rational Design and Discovery of ETX2514, a Novel Broad Spectrum Inhibitor of Class A, C and D β-Lactamases"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Hybrid Antibacterials: A Strategy to Improve Potency and Spectrum"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Antibacterial Agents and Alternative Approaches
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Optimized Arylomycins Are a New Class of Gram-Negative Antibiotics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Bottromycin - Inhibition of Protein Synthesis by a New Binding Mode"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Development of Next Generation Aminoglycosides with Activity Against Multidrug-Resistant Pathogens"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Systems Chemical Biology Approach to Antibiotic Discovery?"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Targeting Clostridium difficile with Novel Classes of Antibiotics"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Exploiting Termite Nest Microbiomes for Antibiotic Discovery"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Overcoming mcr -1 Mediated Colistin Resistance with Colistin in Combination with Other Antibiotics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Antibacterial Agents for Difficult to Eradicate Infections
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Lessons from Oxazolidinones for Tuberculosis Treatment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Lysin CF-301: A Potent Anti-Staphylococcal Biofilm Agent"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Development of Ureadepsipeptides to Treat Difficult to Eradicate Infections"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Antibiotic Inhibition of D-Ala:D-Ala Ligase Through a Novel Phosphoryl Intermediate"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Therapeutic Candidates in the Clinical Development Pipeline
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"LYS228, a Novel Monobactam to Treat Infections Caused by Multi-Drug Resistant Enterobacteriaceae"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Plazomicin Development Program: Lessons Learned from Running Resistant Pathogen Focused Trials"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Potentiation as an Approach to Gram-Negative Anti-Infective Drug Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Anti-Gram-Negative Agent MRX-8: Innovative Polymyxin with Improved Class Safety"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Novel Dual Target Bacterial Replication Inhibitors with Extensive Broad Spectrum Activity"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"TP-6076: Novel Fluorocycline Antibiotic with Potent Activity Against Carbapenem-Resistant Gram-Negative Isolates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Antibacterial Drug Discovery and Development in the Next Decade
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Pathogen Specific Biologic Drugs as Antibacterial Agents: Emil von Behring vs. Sir Alexander Fleming"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Success vs. Failure, and Punishing Good Deeds: Hard Questions for Innovation in Infectious Diseases"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Predictions Are Difficult, Especially When They Are About the Future – So What Should You Consider as You Place Your Bets for the Future"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure