Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Intersection of Artificial Intelligence and Infectious Diseases
Discussion Leader: Zisanur Rahman (University of Manitoba, Canada)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Jonathan Stokes (McMaster University, Canada)
"Generative Artificial Intelligence for Antibiotic Discovery"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reinventing Traditional Approaches in Antibiotic Discovery
Discussion Leader: Samsher Singh (Nanyang Technological University, Singapore, Singapore)
7:30 pm - 7:45 pm
Alexander Abrams (Newcastle University, United Kingdom)
"Validating DnaA as a Drug Target for Antibacterial Drug Discovery"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Yash Acharya (Jawaharlal Nehru Centre for Advanced Scientific Research, India, India)
"Multifunctional Immunomodulatory-Antibacterial Small Molecule Tackles Complicated Bacterial Infection"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Francesca Agobe (Texas A&M School of Medicine, United States)
"A Nanoparticle Lipid Droplet Formulation of the Silver Salt of Ibuprofen to Treat Infections with Multidrug-resistant Pseudomonas aeruginosa "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Danzel Marie Ramirez (University of Manitoba, Canada)
"Application of Tobramycin Benzyl Ether as an Antibiotic Adjuvant Capable of Sensitizing Multidrug-Resistant Gram-Negative Bacteria to Rifampicin"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jickky Palmae Sarathy (Center for Discovery and Innovation - Hackensack Meridian Health, United States)
"Three-Drug Combination of a ß-lactam, a Fluoroquinolone and a Rifamycin Exerts Pronounced Bactericidal Activity Against Mycobacterium Abscessus "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Tian Lan (University of Minnesota, United States)
"Structural Re-Engineering of Rifamycin Antibiotics Against Non-Tuberculous Mycobacteria: A Medicinal Chemistry Perspective"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Novel Techniques and Approaches for Antibiotic Discovery
Discussion Leader: Victoria (Tori) Klein (NIDDK, National Institutes of Health, United States)
9:00 am - 9:15 am
Megan Tu (McMaster University, Canada)
"Exploiting the Fitness Cost of Carbapenem Resistance for the Development of Novel Antimicrobial Approaches"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kelvin Kho (Institut Pasteur, France)
"Developing an AI-Assisted High-Content Screening Pipeline for Antibiotic Discovery"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Rachel Carson (Cornell University, United States)
"Modification of Bacteriophage K To Evade Antiviral Activity in Milk to Treat Bovine Mastitis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Bethan Morris (University of Cambridge, United Kingdom)
"Applying CRISPRi and RNAseq to Target Identification in M. Abscessus Drug Discovery"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Kuan-Yi Lu (UNC-Chapel Hill, United States)
"A High-Throughput Screen to Identify Compounds Sensitizing Intracellular Staphylococcus Aureus "
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Megan Tse (Massachusetts Institute of Technology, United States)
"DropArray: A Massively Parallel Screening Approach for Antibiotic Combinations Discovery Against the Gram-Negative ESKAPE Pathogens"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Early Career Decisions in Academia and Industry
Discussion Leader: Rebecca Ulrich (University of Illinois at Urbana-Champaign, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Early Career Decisions in Academia and Industry
Jonathan Stokes (McMaster University, Canada)
Holly Sutterlin (Prokaryotics Inc., United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes