Nitric Oxide is a simple diatomic molecule, not unlike many other diatomic gases. Yet despite its apparent simplicity, it has over 48 different physiological functions and operates in all organisms from bacteria to humans. The key question that this meeting will address is "How does NO do all this?" The meeting seeks to present the latest research on NO ranging from the basic molecular mechanisms involved in its function to translational endpoints such as physical performance and viral protection. In terms of basic science the meeting will address how NO is produced, what are its major reactive targets, how does it intersect with other reactive molecules, and how does it alter protein function. In addition, we will consider how NO function can be assessed within complex systems and what are some if its downstream endpoints. The meeting will seek to take these mechanistic studies to the clinical level in order to understand how NO can be best optimized in both health and disease. Areas examined will include cellular signaling, human performance, respiratory function including the use of inhaled NO to treat COVID, and how NO can be used to optimize oxygen delivery. The meeting will bring together scientists of quite different backgrounds to discuss how NO functions and how this knowledge can be applied so that everyone can read its signs and understand its signals.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 25, 2020. Please check back for updates.
- Measuring the Effects of NO Signaling
- NO Control of Cellular Phenotype
- NO and Respiratory Health
- Keynote Session: NO and Vascular Function
- Keynote Session: Heme and NO
- Human Performance
- Cysteine Modification as a Target of NO Signaling
- Mechanisms of NO Production
- Regulation of Persulfides