Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Evolving Landscape of Nitric Oxide Research in Redox Signaling and Redox Medicine
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
"Reactive Sulfur Species Regulation of Cardiometabolic Disease"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"The Ever-Expanding Influence of eNOS: Metabolism, Editing and Interferon"
9:10 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chemistry, Pharmacology and Enzymology of Nitric Oxide and Sulfide and Their Relevance in the Cellular Environment
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Exploring the Potential of Hydropersulfides (RSSH) to Rescue Deficient Iron-Sulfur Cluster Biosynthesis and Treat Friedreich’s Ataxia"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Basis for the Scaffolding Activity of Caveolin-1"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Updating the Biological Chemistry of Peroxynitrite"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Stimuli Responsive Nitric Oxide Releasing Materials (NORMs) for Cardiovascular Applications"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Supersulfides Modulate the Entire Process of NLRP3 Inflammasome Activation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Nitric Oxide Controls the Epigenome by Regulating Non-Heme Iron Enzyme Activity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Molecular Insights into a Carbon Monoxide Scavenging Hemoprotein that Exhibits Slow Nitric Oxide Reactivity and Minimal Vaso Activity in Vivo"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
"Free" Heme in Sulfide, Nitric Oxide and Redox Signaling: Molecular Mechanisms, Physiology and Pathology
7:30 pm - 7:50 pm
"New Role for NO in Regulating Cell Heme Allocations and Hemeprotein Activities"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Iron Regulation of Endothelial NO"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Aortic Valve Disease and Systemic Endothelial Function on Nitric Oxide Metabolism"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"New Studies on Heme and Hemoglobin Based NO Signaling"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nitric Oxide and Sulfur Species in Redox Signaling and Cysteine Modification
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Thiol Redox Sensing and Signaling in the Cardiovascular System: Therapeutic Opportunities"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Essential Role of Sulfide Oxidation in Brain Health"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"S-Nitrosylation as a Signal Transduction System"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Aberrant S-Nitrosylation Disrupts TCA Cycle Energy Production in Neurons and thus Contributes to Synapse Loss in Alzheimer’s Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Fatty Acid Nitroalkene Neuroprotection in Parkinson’s Disease"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Phospholipids are Dynamic Reservoirs for Anti-Inflammatory Nitro-Fatty Acids During LPS Challenge"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The Role of Nitric Oxide-Mediated Glutamatergic Alterations in the Shank3Δ4-22 Mouse Model of Autism"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Canonical Signaling and Cell-Cell Communication
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Hydrogen Cyanide, an Emerging Novel Mammalian Gaseous Transmitter"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"From the Culture Dish to Asthma: Redirecting Myeloid Cell Substrate Utilization with Nitro-oleic Acid"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Loss of NO-GC in Periostin+ Myofibroblasts Accelerates Ang II-Mediated Cardiac Remodeling"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Nitrite Modulate Mitochondrial Dynamics to Attenuate Pathological Vascular Remodeling"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Cyclo-Octasulfur Facilitates Energy Metabolism in Mitochondria"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Redox Signaling and Mechanotransduction
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Can You Feel the Force? A New Mode of Mechanosensitive NO-cGMP Signaling in the Cardiovascular System."
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Signaling by Red Blood Cells in Cardiovascular Regulation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Xanthine Oxidoreductase-Dependent Nitrite Reduction in the Cardiovascular System"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"CYB5R3, Calcium, and NO Signaling for Vascular Tone Regulation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"An Endogenous Photonic Signaling Pathway in the Mammalian Brain Modulated by Reactive Oxygen and Nitrogen Species"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Nitrite Reductase-like Activity of Bovine Serum Albumin Mediated by Sodium Ascorbate"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redefining the NO/Sulfide Redox Network: Advances from Single-Cell Analysis, Microproteins, and Microbiome Research
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Identification of Microproteins involved in Endothelial Cell Homeostasis, Endothelial Dysfunction and Vascular Disease"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Endothelial Cell eNOS Specific Regulation of Renal Function In Vivo: Lessons from Loss-of-Function and Gain-of-Function Cell-Specific Mouse Models"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Sulfide Talks, Adipose Tissue Listens"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"3D Modelling of the Influence of iNOS on Triple Negative Breast Cancer Chemotherapeutic Drug Response"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Microbiome-Derived Hydrogen Sulfide as a Metabolic Trigger for CIMP Colorectal Cancer"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Integrating Nitric Oxide and Sulfide Research into Clinical Practice: Pharmacology, Diagnosis, and Prognosis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Exploring High-Dose Inhaled Nitric Oxide as an Innovative Antipseudomonal Treatment"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Novel NO and Heme-Independent sGC Activators: A Treatment Approach for Cardiorenal Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Small Molecule Nitroalkene Regulation of Tissue Metabolic and Inflammatory Stress"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Targeting Soluble Guanylyl Cyclase Activity to Prevent the Development and Progression of Lethal Treatment-Resistant Prostate Cancer"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Continuous Nitric Oxide Inhalation in a Murine Model of Bronchopulmonary Dysplasia and Pulmonary Hypertension"
11:45 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Bringing the Nitric Oxide Field into the Future of Redox Medicine
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"The Role of NO/cGMP in Energy Homeostasis and Brown Adipose Tissue"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Making iNOS/NOS2 A Therapeutic Target: Take 2"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure