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Nitric Oxide

Gordon Research Conference

Nitric Oxide and Sulfide in Redox Signaling and Medicine

February 9 - 14, 2025

Chair

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Nitric Oxide GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 Gordon Research Conference (GRC) on Nitric Oxide marks a significant milestone, celebrating 30 years of groundbreaking research and collaborative scientific exchange. This special anniversary edition, themed "NO and Sulfide in Redox Signaling and Medicine," is designed to highlight cutting-edge advancements in the nitric oxide (NO) field, its interaction with the newly born sulfide field, and how these molecules continue to push the boundaries of science and medicine. This conference is designed to provide a unique opportunity for scientists from diverse fields and at diverse stage of their career to share unpublished findings, discuss novel opportunities, and foster collaborations, thereby advancing our understanding and application of NO and sulfide in health and disease. Invited speakers include experts in chemistry, physiology, pharmacology, and redox medicine.

Related Meeting

This GRC will be held in conjunction with the "Nitric Oxide" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: The Evolving Landscape of Nitric Oxide Research in Redox Signaling and Redox Medicine Discussion Leader:
7:40 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:25 pm	"Reactive Sulfur Species Regulation of Cardiometabolic Disease"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:10 pm	"The Ever-Expanding Influence of eNOS: Metabolism, Editing and Interferon"
9:10 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chemistry, Pharmacology and Enzymology of Nitric Oxide and Sulfide and Their Relevance in the Cellular Environment Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Exploring the Potential of Hydropersulfides (RSSH) to Rescue Deficient Iron-Sulfur Cluster Biosynthesis and Treat Friedreich’s Ataxia"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Molecular Basis for the Scaffolding Activity of Caveolin-1"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Updating the Biological Chemistry of Peroxynitrite"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Stimuli Responsive Nitric Oxide Releasing Materials (NORMs) for Cardiovascular Applications"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Supersulfides Modulate the Entire Process of NLRP3 Inflammasome Activation"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Nitric Oxide Controls the Epigenome by Regulating Non-Heme Iron Enzyme Activity"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Molecular Insights into a Carbon Monoxide Scavenging Hemoprotein that Exhibits Slow Nitric Oxide Reactivity and Minimal Vaso Activity in Vivo"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	"Free" Heme in Sulfide, Nitric Oxide and Redox Signaling: Molecular Mechanisms, Physiology and Pathology Discussion Leaders: and
7:30 pm - 7:50 pm	"New Role for NO in Regulating Cell Heme Allocations and Hemeprotein Activities"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Iron Regulation of Endothelial NO"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Aortic Valve Disease and Systemic Endothelial Function on Nitric Oxide Metabolism"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"New Studies on Heme and Hemoglobin Based NO Signaling"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Nitric Oxide and Sulfur Species in Redox Signaling and Cysteine Modification Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Thiol Redox Sensing and Signaling in the Cardiovascular System: Therapeutic Opportunities"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Essential Role of Sulfide Oxidation in Brain Health"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"S-Nitrosylation as a Signal Transduction System"
10:25 am - 10:30 am	Discussion
10:30 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Aberrant S-Nitrosylation Disrupts TCA Cycle Energy Production in Neurons and thus Contributes to Synapse Loss in Alzheimer’s Disease"
11:15 am - 11:25 am	Discussion
11:25 am - 11:40 am	"Fatty Acid Nitroalkene Neuroprotection in Parkinson’s Disease"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	"Phospholipids are Dynamic Reservoirs for Anti-Inflammatory Nitro-Fatty Acids During LPS Challenge"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	"The Role of Nitric Oxide-Mediated Glutamatergic Alterations in the Shank3^Δ4-22 Mouse Model of Autism"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Non-Canonical Signaling and Cell-Cell Communication Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Hydrogen Cyanide, an Emerging Novel Mammalian Gaseous Transmitter"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:15 pm	"From the Culture Dish to Asthma: Redirecting Myeloid Cell Substrate Utilization with Nitro-oleic Acid"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:30 pm	"Loss of NO-GC in Periostin⁺ Myofibroblasts Accelerates Ang II-Mediated Cardiac Remodeling"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Nitrite Modulate Mitochondrial Dynamics to Attenuate Pathological Vascular Remodeling"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Cyclo-Octasulfur Facilitates Energy Metabolism in Mitochondria"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Redox Signaling and Mechanotransduction Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Can You Feel the Force? A New Mode of Mechanosensitive NO-cGMP Signaling in the Cardiovascular System."
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Signaling by Red Blood Cells in Cardiovascular Regulation"
9:55 am - 10:05 am	Discussion
10:05 am - 10:20 am	"Xanthine Oxidoreductase-Dependent Nitrite Reduction in the Cardiovascular System"
10:20 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"CYB5R3, Calcium, and NO Signaling for Vascular Tone Regulation"
11:05 am - 11:15 am	Discussion
11:15 am - 11:30 am	"An Endogenous Photonic Signaling Pathway in the Mammalian Brain Modulated by Reactive Oxygen and Nitrogen Species"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Nitrite Reductase-like Activity of Bovine Serum Albumin Mediated by Sodium Ascorbate"
11:50 am - 11:55 am	Discussion
11:55 am - 12:25 pm	Poster Previews
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Redefining the NO/Sulfide Redox Network: Advances from Single-Cell Analysis, Microproteins, and Microbiome Research Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Identification of Microproteins involved in Endothelial Cell Homeostasis, Endothelial Dysfunction and Vascular Disease"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Endothelial Cell eNOS Specific Regulation of Renal Function In Vivo: Lessons from Loss-of-Function and Gain-of-Function Cell-Specific Mouse Models"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"Sulfide Talks, Adipose Tissue Listens"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"3D Modelling of the Influence of iNOS on Triple Negative Breast Cancer Chemotherapeutic Drug Response"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Microbiome-Derived Hydrogen Sulfide as a Metabolic Trigger for CIMP Colorectal Cancer"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Integrating Nitric Oxide and Sulfide Research into Clinical Practice: Pharmacology, Diagnosis, and Prognosis Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Exploring High-Dose Inhaled Nitric Oxide as an Innovative Antipseudomonal Treatment"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Novel NO and Heme-Independent sGC Activators: A Treatment Approach for Cardiorenal Diseases"
9:55 am - 10:05 am	Discussion
10:05 am - 10:20 am	"Small Molecule Nitroalkene Regulation of Tissue Metabolic and Inflammatory Stress"
10:20 am - 10:30 am	Discussion
10:30 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Targeting Soluble Guanylyl Cyclase Activity to Prevent the Development and Progression of Lethal Treatment-Resistant Prostate Cancer"
11:15 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Continuous Nitric Oxide Inhalation in a Murine Model of Bronchopulmonary Dysplasia and Pulmonary Hypertension"
11:45 am - 11:55 am	Discussion
11:55 am - 12:25 pm	Poster Previews
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Bringing the Nitric Oxide Field into the Future of Redox Medicine Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	"The Role of NO/cGMP in Energy Homeostasis and Brown Adipose Tissue"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:00 pm	"Making iNOS/NOS2 A Therapeutic Target: Take 2"
9:00 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL178277. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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