1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Cracking the Code of Clinical Translation of Nitric Oxide Science
Ben Gaston (Indiana University School of Medicine, United States)
3:45 pm - 4:20 pm
Nathan Bryan (Nitric Oxide Innovations, LLC, United States) "Cracking the Code of Clinical Translation of Nitric Oxide Science"
4:20 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Chemical biology of Nitric Oxide and Reactive Species
Zohreh Safari (University of Maryland School of Medicine, United States) and Ramesh Chennupati (Universitätsklinikum Düsseldorf, Germany)
7:30 pm - 7:40 pm
Lauryn Ridley (NIAID, United States) "Using Molecular Modeling and Biochemical Analysis to Examine The Effect of The Sickle Cell Mutation on The Interactions Between Hemoglobin and eNOS"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Gurneet Sangha (University of Maryland, United States) "Mechanosensitive Piezo1 Stimulation Increases Red Blood Cell and Endothelial Cell Nitric Oxide Through Different Pathways"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Nicki Dyson (Queen Mary University of London , United Kingdom) "Nitrite Reductase Activity of Liver-derived Xanthine Oxidoreductase Maintains Cardiovascular Homeostasis"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Titus Gehling (University of Cologne, Germany) "Nitrite-dependent NO Synthesis in Mitochondria by Sulfite Oxidase"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
Matthew Dent (University of Pittsburgh, United States) "Characterization of a Novel CO Binding Transcription Factor as a CO Poisoning Antidote that Elicits Limited Hypertension in Vivo"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Nicole Colussi (University of Pittsburgh, United States) "Defining the Mechanism of Action for NO
2-CLA: Integration of Phospholipid Substrates and Protein Targets for Signaling in the Context of Inflammation and Ischemia-reperfusion Injury"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Joaquin Ortiz de Zevallos (University of Virginia, United States) "Sexual Dimorphism in Exercise Economy, Exercise Capacity and Skeletal Muscle Contractile Function: Effects of Dietary Nitrate Supplementation"
9:10 pm - 9:15 pm
9:15 pm - 9:25 pm
Ciara O'Neill (University of Galway, Ireland) "Comparison Of Nitric Oxide Delivery Via No Donors Versus iNOS Overexpression in HER2-Amplified Breast Cancer"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Endogenous Nitric Oxide and Signaling Pathways
Anthea Lo Bue (Heinrich-Heine University, Germany) and Ronghua Wang (University of Pittsburgh School of Medicine, United States)
9:00 am - 9:10 am
ELISA ZUCCARELLO (COLUMBIA UNIVERSITY, United States) "Drug Development of Novel Phosphodiesterase 5 Inhibitors for the Therapy of Alzheimer’s Disease"
9:10 am - 9:15 am
9:15 am - 9:25 am
Jeeyoung Lee (NIH, United States) "Erythropoietin Modulates Heart Function in Obese Mice Requiring Neuronal Nitric Oxide Synthase and Independent of Erythropoiesis"
9:25 am - 9:30 am
9:30 am - 9:40 am
Kai Sun (Houston Methodist Cancer Center, United States) "Pan-NOS Inhibitor L-NMMA Enhances Antitumor Effect of Docetaxel in Obesity-associated Triple Negative Breast Cancer"
9:40 am - 9:45 am
9:45 am - 9:55 am
Lucas Carvalho (Karolinska Institutet, Sweden) "Therapeutic Effects of Dietary Amino Acids and Beetroot Extract Supplementation in a Novel Model of Diabetic Nephropathy"
9:55 am - 10:00 am
10:00 am - 10:10 am
Junjie Li (Heinrich-Heine-University Düsseldorf, Germany) "Generation and Phenotyping of RBC Arg1 KO Mice"
10:10 am - 10:15 am
10:15 am - 10:25 am
Haruna Takeda (Tohoku University, Japan) "Single Cell Multiomics Reveals Polysulfide-Dependent Regulation of Hematopoietic Stem Cell Differentiation"
10:25 am - 10:30 am
10:30 am - 10:40 am
Pia Burboa (Rutgers Biomedical and Health Sciences, United States) "Inactivation of Inflammation-induced Hyperpermeability is Mediated by eNOS Trafficking"
10:40 am - 10:45 am
10:45 am - 10:55 am
Elise Femino (National Cancer Institute, United States) "NOS2 and COX2 Expression Correlates with Prognosis of Estrogen Receptor Negative and Triple Negative Breast Cancer"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Options: Flexibilities, Adaptation and Communication
Matthew Dent (University of Pittsburgh, United States)
1:30 pm - 2:30 pm
Intentionally Inclusive Environments for Better Communication
Debashree Basudhar (Bristol Myers Squibb, United States)
Brant Isakson (University of Virginia School of Medicine, United States)
Amrita Ahluwalia (Queen Mary University of London, United Kingdom)
Edward Moreira Bahnson (University of North Carolina at Chapel Hill, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)