Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Setting Notch in Context
Discussion Leaders: Anna Bigas (Hospital del Mar Medical Research Institute (IMIM), Spain) and Robert Haltiwanger (University of Georgia, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Nancy Speck (University of Pennsylvania, United States)
"Hematopoietic Stem Cell Formation in the Embryo"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Kun-Liang Guan (University of California, San Diego, United States)
"The Hippo Pathway in Tissue Homeostasis and Cancer"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structure and Mechanisms of Notch Activation
Discussion Leader: David Sprinzak (Tel Aviv University, Israel)
9:00 am - 9:20 am
Stephen Blacklow (Harvard Medical School, United States)
"Structural Basis for Selective ADAM10 Proteolysis at Membrane-Proximal Sites"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Penny Handford (University of Oxford, United Kingdom)
"The Importance of N-glycans, as Well as Lipids, for Ligand-Dependent Notch Signalling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Wendy Gordon (University of Minnesota, United States)
"Updates on Notch Mechanotransduction"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
John Ngo (Boston University, United States)
"Synthetic Mechanobiology: Engineering How Cells Sense and Interpret Mechanical Cues"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Emma Andersson (Karolinska Institutet, Sweden) and Warren Pear (University of Pennsylvania, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcription, Epigenetics and Notch
Discussion Leaders: Rachael Kuintzle (California Institute of Technology, United States) and Roshana Thambyrajah (Fundació IMIM, Spain)
7:30 pm - 7:50 pm
Sarah Bray (University of Cambridge, United Kingdom)
"Programming the Notch Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Robert Faryabi (University of Pennsylvania, United States)
"Plasticity of Notch-Mutated Cancer Genome Topology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Cheng-Yu Lee (University of Michigan, United States)
"Fruitless Modulates the Threshold of Notch Target Gene Transcription During Asymmetric Neuroblast Division"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch, Development and Homeostasis
Discussion Leader: Sarah Bray (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Francois Schweisguth (Institut Pasteur, France)
"Patterning Dynamics in the Drosophila Eye"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Carmen Birchmeier (Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany)
"Oscillations of MyoD and Notch Signaling Control Self-Renewal and Differentiation of Skeletal Muscle Stem Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Ertugrul Ozbudak (Cincinnati Children's Hospital Medical Center, United States)
"Somite Segmentation Without Notch Pathway Oscillations"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kim Dale (University of Dundee, United Kingdom)
"Regulation of NICD Turnover in iPs-Derived Presomitic Mesoderm"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Sprinzak (Tel Aviv University, Israel)
"Mechano-Signaling Feedback Underlies Precise Patterning in the Inner Ear"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Christian Siebel (Genentech, United States)
"Notch Control of Adult Whole-Body Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Notch, Cancer and Therapeutics
Discussion Leader: Lucio Miele (LSU Health Sciences Center New Orleans, United States)
7:30 pm - 7:50 pm
Rumela Chakrabarti (University of Miami, United States)
"Targeting Dll1-Mediated Tumor-Stromal Cell Crosstalk in Drug-Resistant Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Jon Aster (Brigham and Women's Hospital, United States)
"Notch Signaling and the B Cell Lymphoma Microenvironment"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Frank Kuhnert (Regeneron Pharmaceuticals, Inc., United States)
"Exploring New Notch-Related Therapeutic Targets in T-ALL"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Shmuel Tuvia (Ayala, Israel)
"Targeting Notch-Dependent Tumors with GSIs (AL101& AL102)"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Rajwinder Lehal (Cellestia Biotech AG, Switzerland)
"Targeting CSL-NICD TF: A Pre-clinical and Clinical Update on CB-103"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch and Liver Disease
Discussion Leader: Kim Dale (University of Dundee, United Kingdom)
9:00 am - 9:20 am
David Piccoli (Children's Hospital of Philadelphia, United States)
"Alagille Syndrome: From the Bedside to the Bench - 50 Years and Counting"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Emma Andersson (Karolinska Institutet, Sweden)
"Notch Control of Liver and Vascular Development"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stacey Huppert (Cincinnati Children's Hospital Medical Center, United States)
"Building a Functional Biliary System via Hepatocyte Plasticity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hamed Jafar-Nejad (Baylor College of Medicine, United States)
"Dosage-Sensitive Modifiers of Notch Signaling in a Mouse Model of Alagille Syndrome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Utpal Pajvani (Columbia University, United States)
"The Metabolic Consequences of Aberrant Hepatocyte Notch Signaling in Obesity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Approaches, Phenotypes and Opportunities
Discussion Leader: Christian Siebel (Genentech, United States)
7:30 pm - 7:50 pm
Nathalie Labrecque (University of Montreal, Canada)
"Notch Signaling Controls the CD8+ T Cell Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Vincent Luca (Moffitt Cancer Center & Research Institute, United States)
"Maxing Out Notch Signaling: Evolution of an Ultrapotent DLL4 Ligand for Biomedical Applications"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Duc Dong (Sanford Burnham Prebys Medical Discovery Institute, United States)
"Augmenting Regeneration Using a Small Molecule Notch Agonist"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Marc Vooijs (Maastricht University, The Netherlands)
"Iron Transport Controls Notch-Mediated Cell Fates"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Endothelial Cell Function and Vessel-Tissue Crosstalk by Notch"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Late-Breaking Topics
Discussion Leader: Warren Pear (University of Pennsylvania, United States)
9:00 am - 9:10 am
Daniel Lafkas (Genentech, United States)
"A JAG-NOTCH2 Blocking Antibody for the Treatment of Muco-Obstructive Diseases"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Leslie Kean (Boston Children's Hospital, United States)
"Targeting Notch in Graft-Versus-Host Disease: Early Inhibition and its Impact on Pathogenic T Cell Trafficking to the Gut"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Blood and Vessels
Discussion Leader: Irwin Bernstein (University of Washington, United States)
7:30 pm - 7:50 pm
Roshana Thambyrajah (Fundació IMIM, Spain)
"Distinct Notch Receptor-Ligand Interactions Govern the Emergence of Hematopoietic Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Rui Benedito (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"Targeting Notch Ligands Versus Their Receptors – Same Signaling Pathway But Very Distinct Outcomes in Single Cell Vascular Pathophysiology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Julia Mack (UCLA, United States)
"Flow-Induced Endothelial Planar Polarity and Signaling Regulation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure