Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Keynote Session: Notch Signaling in Biology 
 
 
 
						
7:40 pm - 8:20 pm 
	
"Notch Signaling: A Paradigm of Biological Complexity" 
 
 
 
						
8:20 pm - 8:35 pm 
	
Discussion
 
 
						
8:35 pm - 9:15 pm 
	
"Impacts of Notch Signaling on a Multipotent Progenitor-Cell Gene Regulatory Network to Initiate T Cell Development" 
 
 
 
						
9:15 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Structure and Mechanisms of Notch Activation and Modulation 
 
 
 
						
9:00 am - 9:20 am 
	
"Notch Induces Transcription by Stimulating Release of Paused RNA Pol II Without Increasing Chromatin Accessibility" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Significance of Site-Specific Xylosyl-Elongation of O-Glucose Glycans in Notch Signaling" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Development of Notch Agonists through Protein Engineering and Multivalent Scaffolds" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Neuralized-Like Proteins Differentially Activate Notch Ligands" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Regulation of Notch Signaling by O-Glycans in Intestinal and Immune Cell Development" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
""Snags" in the Development of Targeted Notch Signaling Modulators" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Notch, Cancer, and Therapeutics 
 
 
 
						
7:30 pm - 7:50 pm 
	
"A Critical Role of Notch Signaling in the Immune Response to SARS-CoV-2 mRNA Vaccination" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Notch: Cell Plasticity and Therapeutic Escape in Triple Negative Breast Cancer" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:40 pm 
	
"Notch-Hippo Signaling Increases Cholesterol Metabolism in Tumor Associated Macrophages Promoting Resistance to Therapy in Breast Cancer" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"A Non-Coding Mutation Within the NOTCH1 Gene Overrides Tumor Suppressor Activity in Chronic Lymphocytic Leukemia (CLL)" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Developing Synthetic Notch Agonists to Control Cell Fate Switches and Understand Receptor Activation Mechanisms" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Targeting JAG1 Overcomes Pancreatic Cancer Immunotherapy Resistance by Reinvigorating cDC1 and CD8 T cells" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Notch, Development, and Homeostasis 
 
 
 
						
9:00 am - 9:20 am 
	
"Towards an AAV-Based Therapeutic Strategy for Alagille Syndrome" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Multiple Roles for Notch Signaling in the Prenatal Mouse Eye" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Notch-Driven Hepatocyte Plasticity Reveals Undiscovered Liver Temporal Reprogramming Competency" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Studying Regulation of Intrahepatic Bile Duct Development by Notch Signaling Using Advanced Imaging and in Utero Gene Expression Manipulation" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Notch is Essential for Adult Thyroid Function Through Maintaining Proper Mitochondrial Activity" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Defective Notch Signaling in Endothelial Cells is a Primary Driver of Pathogenesis in a Mouse Model of Adams Oliver Syndrome" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Macrophages Carrying Pecanex Mutation Secrete an Inhibitor that Suppresses Notch Signaling During Lateral Inhibition" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Dynamic Notch Diversifies Newborn Neurons Serially Made by a Common Fly Neural Stem Cell" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Late-Breaking Topics in Notch Biology 
 
 
 
						
7:30 pm - 7:40 pm 
	
"Tracing Notch Activity with CRISPR Barcode Recorders" 
 
 
 
						
7:40 pm - 7:45 pm 
	
Discussion
 
 
						
7:45 pm - 7:55 pm 
	
"Design of a Soluble Multivalent Notch Agonist for the Generation of T Cell from Pluripotent Stem Cells" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:10 pm 
	
"Neuralized- and Mib1-Mediated Activation of Ser-Signalling" 
 
 
 
						
8:10 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:25 pm 
	
"An in Vivo Screen to Identify Protein Domains that are Cleaved in Response to Force Provided by Epsin-Mediated Ligand Endocytosis" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:40 pm 
	
"Protein Design Approaches to Targeted Modulation of Notch Receptor Signaling" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"Notch Activity Coordinates Dynamic Mastermind “Hubs” to Instruct Transcription" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Optical Reconstruction of EBF1-Driven Enhancer-Promoter Hubs in Individual Cells" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Casein Kinase 1 Alpha (CK1a) Fine-Tunes Notch Intracellular Domain 1 (N1ICD) Stability and Function" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Notch and Cardiovascular Disorders 
 
 
 
						
9:00 am - 9:20 am 
	
"Notch Signaling in Vascular Cells, New Directions and More Surprises" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Role of Notch Signaling in Vascular Aging" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Heterogeneous Outcomes of Different CADASIL Mutants on Endocytic NOTCH3 Activation Mechanisms" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Elucidating of the Molecular Progression of Hereditary Vascular Dementia in a Novel Mouse Model" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Notch Signaling in Arterial Venous Programming, Disease, and Regeneration" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"The Genetics of Cardiomyopathy and Bicuspid Aortic Valve Involves NOTCH Signaling Disruption" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Inhibition of RUNX1 Curbs Vascular Pathology and Inflammation in CADASIL" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Notch Transcriptional Target Tmtc1 Maintains Vascular Homeostasis" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Tools to Study Notch Signaling in Tissue Development and Diseases 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Tissue Microenvironment Engineering for the Study of Liver Differentiation and Notch Signaling" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Hematopoietic Notch Signaling in the Fetal and Adult Liver" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:40 pm 
	
"Visualization of Notch Signaling Dynamics in Development and Tissue Homeostasis" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"The Notch Ligand DLL1 Defines a Balance Between Trans-Activation and Cis-Inhibition to Regulate Human Somitogenesis" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Notch Receptor-Ligand System Facilitates Extracellular Vesicle-Mediated Neuronal Communication" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"The Dual Role of Notch Ligand Jagged1 in Cochlear Supporting Cell Plasticity and Hair Cell Regeneration" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Stem Cell and Niche Interactions 
 
 
 
						
9:00 am - 9:20 am 
	
"Notch, Niches and Regulation of Intestinal Stem Cells" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"New Roles for Jag 1 in Cochlear Development" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"A Notch Trans-Activation to Cis-Inhibition Switch Underlies Hematopoietic Stem Cells Aging" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"DLK1 Phase Separation Controls Multiple Signaling Pathways" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:20 am 
	
"Symmetry Breaking and Self-Organization of Bi-Layered Epithelia are Orchestrated by Conserved Signals During Development and Regeneration" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Coordinated Regulation of Notch Signaling by Glycosylation and Cis Inhibition" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Targeting Endothelial PERK-DLL4 Axis to Enhance Hematopoietic Stem Cell and Lymphoid Progenitor Regeneration" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Hyperactive Notch Signaling as a Potential Mechanism of PIGA– HSPC Clonal Expansion in Immune Bone Marrow Injury" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Transcription, Epigenetics, and Notch 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Comprehensive Genomic Features Indicative for Notch Responsiveness" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"T cells and Notch, a Lifelong Engagement" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:40 pm 
	
"CSL as a Target for Inducing Immune Tolerance by Modulating Treg Cells and Application in Autoimmune Diseases" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"Oncogenic Transcription Factors Instruct Promoter-Enhancer Hubs in Individual Triple Negative Breast Cancer Cells" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Comprehensive Characterization of a Notch3-driven Preclinical Mouse Model of Lateral Meningocele Syndrome" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Divalent Metal Transporter 1(DMT1) Modulates Notch Signaling by Influencing Iron Storage and Lysosomal Stability" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure