Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Notch Signaling in Biology
Discussion Leader: Pamela Stanley (Albert Einstein College of Medicine, United States)
7:40 pm - 8:20 pm
Spyros Artavanis-Tsakonas (Harvard, United States)
"Notch Signaling: A Paradigm of Biological Complexity"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Ellen Rothenberg (California Institute of Technology, United States)
"Impacts of Notch Signaling on a Multipotent Progenitor-Cell Gene Regulatory Network to Initiate T Cell Development"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structure and Mechanisms of Notch Activation and Modulation
Discussion Leader: Stephen Blacklow (Harvard Medical School, United States)
9:00 am - 9:20 am
Julia Rogers (Harvard Medical School, United States)
"Notch Induces Transcription by Stimulating Release of Paused RNA Pol II Without Increasing Chromatin Accessibility"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hideyuki Takeuchi (University of Shizuoka School of Pharmaceutical Sciences, Japan)
"Significance of Site-Specific Xylosyl-Elongation of O-Glucose Glycans in Notch Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Pamela Stanley (Albert Einstein College of Medicine, United States)
"Regulation of Notch Signaling by O-Glycans in Intestinal and Immune Cell Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Vincent Luca (Moffitt Cancer Center & Research Institute, United States)
""Snags" in the Development of Targeted Notch Signaling Modulators"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Luisa Iruela-Arispe (Northwestern University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Notch, Cancer, and Therapeutics
Discussion Leader: Jon Aster (Brigham and Women's Hospital, United States)
7:30 pm - 7:50 pm
Ivan Maillard (University of Pennsylvania, United States)
"A Critical Role of Notch Signaling in the Immune Response to SARS-CoV-2 mRNA Vaccination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Freddy Radtke (École Polytechnique Fédérale de Lausanne, Switzerland)
"Notch: Cell Plasticity and Therapeutic Escape in Triple Negative Breast Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch, Development, and Homeostasis
Discussion Leader: Christian Siebel (Genentech, United States)
9:00 am - 9:20 am
Hamed Jafar-Nejad (Baylor College of Medicine, United States)
"Towards an AAV-Based Therapeutic Strategy for Alagille Syndrome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nadean Brown (University of California, Davis, United States)
"Multiple Roles for Notch Signaling in the Prenatal Mouse Eye"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Susan Cole (The Ohio State University, United States)
"Coordinated Regulation of Notch Signaling by Glycosylation and Cis Inhibition"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Brian Gebelein (Cincinnati Children's Research Foundation, United States)
"Defective Notch Signaling in Endothelial Cells is a Primary Driver of Pathogenesis in a Mouse Model of Adams Oliver Syndrome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leader: David Sprinzak (Tel Aviv University, Israel)
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch and Cardiovascular Disorders
Discussion Leader: Sarah Bray (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Luisa Iruela-Arispe (Northwestern University, United States)
"Notch Signaling in Vascular Cells, New Directions and More Surprises"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Joseph Arboleda-Velasquez (Schepens Eye Research Institute, Mass Eye and Ear / Harvard Medical School, United States)
"Role of Notch Signaling in Vascular Aging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rong Wang (University of California, San Francisco, United States)
"Notch Signaling in Arterial Venous Programming, Disease, and Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jose Luis De La Pompa (Centro Nacional de Investigaciones Cardiovasculares , Spain)
"The Genetics of Cardiomyopathy and Bicuspid Aortic Valve Involves NOTCH Signaling Disruption"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organoids to Study Notch Signaling in Tissue Development and Diseases
Discussion Leaders: Ishita Jain (Stanford University, United States) and Thilinie Bandara (University of Illinois at Chicago, College of Medicine, United States)
7:30 pm - 7:50 pm
Gregory Underhill (University of Illinois at Urbana-Champaign, United States)
"Tissue Microenvironment Engineering for the Study of Liver Differentiation and Notch Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Cecilia Sahlgren (Åbo Akademi University, Finland)
"Engineered Models to Study Mechanoregulation of Notch Signaling in the Arterial Wall"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Stem Cell and Niche Interactions
Discussion Leader: Irwin Bernstein (Fred Hutchinson Cancer Center, United States)
9:00 am - 9:20 am
Linda Samuelson (University of Michigan, United States)
"Notch, Niches, and Intestinal Stem Cell Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brandon Hadland (Fred Hutchinson Cancer Research Center, United States)
"Deconstructing Notch-Dependent Vascular Niche Signals to Engineer HSC Development ex vivo "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Silvia Fre (Institut Curie, France)
"Symmetry Breaking and Self-Organization of Bi-Layered Epithelia Are Orchestrated by Conserved Signals During Development and Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Lluc Mosteiro (Genentech, United States)
"Notch is Essential for Adult Thyroid Function Through Maintaining Proper Mitochondrial Activity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcription, Epigenetics, and Notch
Discussion Leader: Warren Pear (University of Pennsylvania, United States)
7:30 pm - 7:50 pm
Tilman Borggrefe (University of Giessen, Germany)
"Comprehensive Genomic Features Indicative for Notch Responsiveness"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Juan Carlos Zuniga-Pflucker (University of Toronto, Canada)
"T cells and Notch, a Lifelong Engagement"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure