Sunday
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4:00 pm - 8:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Intracellular Communication via ROS: Insights into Mitochondria
Discussion Leader: Albert Van Der Vliet (University of Vermont, USA)
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7:40 pm - 7:50 pm |
Opening Remarks
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7:50 pm - 8:00 pm |
Introduction by Discussion Leader
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8:00 pm - 8:25 pm |
Alicia Kowaltowski (Universidade de Sao Paulo, Brazil)
"Mitochondria, Dietary Interventions and Oxidants"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:55 pm |
Fabio Di Lisa (University of Padova, Italy)
"Sources and Targets of Mitochondrial ROS Formation in Cardiac Pathophysiology"
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8:55 pm - 9:00 pm |
Discussion
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9:00 pm - 9:25 pm |
Douglas Thomas (University of Illinois at Chicago, USA)
"Epigenetics: The Third Pillar of Nitric Oxide Signaling in Cancer"
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9:25 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
NOX Back to Basics: Bridging Knowledge for the Future
Discussion Leader: Robert Clark (University of Texas Health Science Center at San Antonio, USA)
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9:00 am - 9:10 am |
Introduction by Discussion Leader
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9:10 am - 9:30 am |
Susan Smith (Kennesaw State University, USA)
"NOX Structure from Models to Crystals and Back"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:00 am |
Hideki Sumimoto (Kyushu University, Japan)
"Localization, Regulation and Function of NOX Family Oxidases"
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10:00 am - 10:10 am |
Discussion
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10:10 am - 10:30 am |
Edgar Pick (Tel Aviv University, Israel)
"The N-Terminal SH3 Domain of p67-Phox: An Orphan Region in Search of a Ligand"
|
10:30 am - 10:40 am |
Discussion
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10:40 am - 11:05 am |
Coffee Break
|
11:05 am - 11:15 am |
Introduction by Discussion Leader
|
11:15 am - 11:30 am |
Vincent Jaquet (University of Geneva, Switzerland)
"How to Measure NOX Activity and Validate NOX Inhibitors"
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11:30 am - 11:40 am |
Discussion
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11:40 am - 11:55 am |
Katrin Schröder (Goethe University Frankfurt, Germany)
"Advantages and Challenges of Membrane Assay Systems to Measure ROS"
|
11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Becky Diebold (Emory University, USA)
"Detecting NADPH Oxidases by PCR and Western Blots: Not So Simple"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Group Photo / Lunch
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1:30 pm - 4:30 pm |
Free Time
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
From Structural Mechanisms to NOX Drug Development
Discussion Leader: Susan Smith (Kennesaw State University, USA)
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6:00 pm - 6:25 pm |
Andrea Mattevi (University of Pavia, Italy)
"Looking at the Three-Dimensional Structure of NOX"
|
6:25 pm - 6:35 pm |
Discussion
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6:35 pm - 6:55 pm |
Marie Erard (University of Paris-Saclay, UMR 8000, CNRS, France)
"The Cytosolic Complex of the Phagocyte NADPH Oxidase: From Quantitative Live Cell Imaging to 3D Model"
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6:55 pm - 7:00 pm |
Discussion
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7:00 pm - 7:20 pm |
Franck Fieschi (Université Grenoble Alpes, France)
"NOX-Related Membrane Proteins and the Prokaryotic World"
|
7:20 pm - 7:25 pm |
Discussion
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7:25 pm - 7:50 pm |
Philippe Wiesel (Genkyotex SA, Switzerland)
"Targeting Inflammatory Pain and Angiogenesis with the Selective NOX1 Inhibitor GKT771"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
ROS Signaling and Networking
Discussion Leader: Miklós Geiszt (Semmelweis University, Hungary)
|
9:00 am - 9:25 am |
Harald Schmidt (Maastricht University, The Netherlands)
"Systems Medicine of ROS-Related Diseases"
|
9:25 am - 9:35 am |
Discussion
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9:35 am - 10:00 am |
Melissa Kemp (Georgia Institute of Technology / Emory University, USA)
"NOX Activity in Systems Biology Modeling of Redox Signaling and Metabolism"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:40 am |
Coffee Break
|
10:40 am - 11:05 am |
Valentin Cracan (Harvard Medical School / Massachusetts General Hospital, USA)
"Genetically Encoded Tools for Compartment-Specific Manipulation of NAD+/NADH and NADP+/NADPH Ratios in Living Cells"
|
11:05 am - 11:15 am |
Discussion
|
11:15 am - 11:35 am |
Fabian Hahner (Universitätsklinikum Frankfurt, Germany)
"The NADPH Oxidase NOX4 Promotes Endothelial Differentiation"
|
11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Lucia Lopes (University of Sao Paulo, Brazil)
"Redox Activation of NOX1 Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells"
|
11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Yukio Nishimoto (Chubu University, Japan)
"Constitutively Active NADPH Oxidase 4 Functions as a Hydrogen Peroxide Sensor"
|
12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"Dissecting the Role of the NADPH Oxidase NOX4 During Liver Regeneration"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Hallmarks of NOX Function - Immunity and Inflammation
Discussion Leader: Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Switzerland)
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6:00 pm - 6:25 pm |
Yun Soo Bae (Ewha Womans University, South Korea)
"Regulation of NOX Activity by TLR in Inflammation"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Rikard Holmdahl (Karolinska Institutet, Sweden)
"ROS Regulation of Autoimmune Disease"
|
7:00 pm - 7:10 pm |
Discussion
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7:10 pm - 7:35 pm |
Harry Malech (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Progress Towards CRISPR Mediated Gene Editing Correction of Chronic Granulomatous Disease in Patient CD34+ Hematopoietic Stem Cells"
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7:35 pm - 7:45 pm |
Discussion
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7:45 pm - 7:55 pm |
Marie Jose Stasia (Université Grenoble Alpes, France)
"Downregulation of NOX2 Activity in Phagocytes Mediated by ATM Kinase Dependent Phosphorylation"
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7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
ROS as Key Player in Interkingdom Crosstalk at Barriers
Discussion Leader: Marie Jose Stasia (Université Grenoble Alpes, France)
|
9:00 am - 9:05 am |
Introduction by Discussion Leader
|
9:05 am - 9:30 am |
Gerard Clarke (University College Cork, Ireland)
"Crosstalk in the Microbiome-Gut-Brain Axis and Host Behavior: Focus on Microbial Regulation of Tryptophan Metabolism"
|
9:30 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Helmut Grasberger (University of Michigan, USA)
"DUOX in Gut Health and Disease"
|
10:05 am - 10:15 am |
Discussion
|
10:15 am - 10:40 am |
Coffee Break
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10:40 am - 11:05 am |
Kim Orth (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, USA)
"Vibrio: Subverting ROS for Survival and Proliferation in a Host Cell"
|
11:05 am - 11:15 am |
Discussion
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11:15 am - 11:35 am |
Silvia Cellone Trevelin (King's College London, United Kingdom)
"Regulatory T Cells Deficient in NOX2 Limit Angiotensin II-Induced Hypertension and Cardiovascular Remodeling"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Ashish Singh (University College Dublin, Ireland)
"Hydrogen Peroxide Production by Lactobacilli Prevents Colitis and Intestinal Infection"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Sjoerd van der Post (Washington University in St. Louis, USA)
"NOX1-Dependent Redox Signaling Mediates Colonic Stem Cell Proliferation via EGFR Potentiated by Microbial Components"
|
12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Corinne Dupuy (Institut Gustave Roussy / CNRS, France)
"Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Redox Signals in Cancer - From NOS to NOX
Discussion Leader: David Lambeth (Emory University, USA)
|
6:00 pm - 6:05 pm |
Introduction by Discussion Leader
|
6:05 pm - 6:30 pm |
Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Memo1, a Redox Protein with Roles in Aging and in Cancer"
|
6:30 pm - 6:40 pm |
Discussion
|
6:40 pm - 7:05 pm |
James Doroshow (National Cancer Institute, NIH, USA)
"NADPH Oxidases, Pro-Inflammatory Cytokines, and Inflammation-Related Cancers"
|
7:05 pm - 7:15 pm |
Discussion
|
7:15 pm - 7:40 pm |
Thomas Leto (National Institute of Allergy and Infectious Diseases, NIH, USA)
"NOX4 Involvement in Cancer Progression"
|
7:40 pm - 7:50 pm |
Discussion
|
7:50 pm - 8:00 pm |
General Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
NOXes in Disease Pathophysiology
Discussion Leader: Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
|
9:00 am - 9:25 am |
David Brenner (University of California, San Diego, USA)
"The Role of NOXs in Liver Fibrosis and Cancer"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Louise Hecker (University of Arizona, USA)
"Pre-Clinical Development of Novel NOX4 Inhibitors for Targeting Age-Associated Pathological Fibrosis"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:35 am |
Coffee Break
|
10:35 am - 11:00 am |
Karl-Heinz Krause (University of Geneva, Switzerland)
"NOX Enzymes in Inner Ear Pathology"
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:35 am |
Simone Di Giovanni (Imperial College London, United Kingdom)
"NOX2 Signaling Pathways Underpin Injury and Environmentally Driven Axonal Regeneration Following Nerve and Spinal Injuries"
|
11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Ildiko Szanto (Geneva University Hospitals, Switzerland)
"Beta-Cell Specific Overexpression of the NADPH Oxidase 5 (NOX5) Deteriorates Islet Cell Function in High-Fat Diet Exposed Mice"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Natalie Torok (University of California, Davis, USA)
"NOX2 Activation by p52Shc Leads to Accelerated Liver Fibrosis in Aging Mice"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Carmen Veith (Maastricht University, The Netherlands)
"Profibrotic Signaling by TGF-b1 Involves NADPH Oxidase 4-Dependent Activation of the Tyrosine Kinase Fyn"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
NOX-Mediated ROS Signaling in Metabolism and Cardiovascular Disease
Discussion Leader: Rhian Touyz (University of Glasgow, United Kingdom)
|
6:00 pm - 6:25 pm |
Jun Sadoshima (Rutgers New Jersey Medical School, USA)
"The Cell Type-Specific Function of NOX4 During Heart Failure"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Ajay Shah (King's College London, United Kingdom)
"NOX4 and Metabolic Reprogramming"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:35 pm |
Lev Becker (University of Chicago, USA)
"NOX2 Signaling in Macrophages Supports Detrimental and Beneficial Functions in Obesity and Type 2 Diabetes"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 8:00 pm |
Closing Remarks
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|