The NOX Family NADPH Oxidases GRC meets biennially, in either the USA or in Europe, and features state-of-the-art unpublished work covering the multidisciplinary scope of research in this area, and is preceded by a NOX Gordon Research Seminar (GRS) for early-stage investigators in this field. NOX enzymes are distributed widely in nature and have emerged as primary sources of regulated production of reactive oxygen-derived species (ROS). They therefore play primary roles in biological systems by mediating redox-based signaling pathways, a concept that has diverged substantially from the more traditional viewpoint of ROS as damaging and stress-inducing agents. Functional roles of NOX enzymes in various aspects of biology, beyond their original role in host defense, are being discovered at a rapid pace, and dysregulated NOX function (e.g. due to genetic NOX variants or inappropriate expression) is increasingly implicated in disease pathology.
The NOX GRC brings together scientists from diverse disciplines at this premier forum to discuss state-of-the-art research in this field in a highly collegial, collaborative, and informal atmosphere. The 2020 NOX GRC focuses on innovative and paradigm-challenging topics, presented by internationally recognized experts and followed by ample time for discussions coordinated by expert discussion leaders. Topics covered at the 2020 NOX GRC include: structure/functional aspects of NOX enzymes, novel modes of NOX regulation, functional interactions with ion channels and other redox enzymes and redox-sensitive protein targets, and newly emerging interactions of NOX with cell metabolism. The meeting will also cover new translational studies addressing the involvement of NOX in chronic inflammatory diseases and metabolic diseases such as cancer, and recent progress with development of NOX-selective inhibitors. Keynote lectures by highly esteemed scientists will highlight the unique and prominent role of NOX enzymes in the broader field of redox biology.
The NOX GRC is organized to reflect gender and geographic diversity of the field, and will allow for inclusion of late-breaking science and short talks selected from submitted abstracts. The meeting also includes stimulating poster sessions, preceded by "poster preview" presentations earlier in the morning sessions, which allow for more extensive discussion and facilitate career development opportunities for early-career investigators in this field. Please do not miss out on this exciting meeting!
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2019. Please check back for updates.
- Keynote Session: The NOX Family in the World of Redox Biology
- NOX Structure and Functional Regulation
- Novel Tools to Assess NOX Activity and Function
- Peroxidases, Thiol Proteins and Ion Channels as NOX Targets
- NOX in Immunology and Microbiome Regulation
- NOX in Cellular Metabolism and Metabolic Disease
- Subcellular Actions of NOX
- NOX in Cell Differentiation and Stem Cell Function: Implications for Disease Pathology
- NOX in Translation: Implications for Clinical Application