| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Introduction to the Nox world |
| 3:45 pm - 4:15 pm | Dave Lambeth (Emory University)
"Nox enzymes and the quest to subdue the savage radical"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Understanding Mechanisms of Nox Regulation |
| Discussion Leader: Jennifer Meitzler (National Institutes Of Health) |
| 7:30 pm - 7:45 pm | Laura Baciou (University Paris Sud-CNRS)
"How trans-arachidonic acid Isomer inhibits NADPH-Oxidase activity"
|
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Eva Crosas-Molist (Bellvitge Biomedical Research)
"NOX4 plays a tumor suppressor role in hepatocellular carcinoma cells"
|
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Thalita Abroahao (INCOR)
"Compartmentalization of redox processes, Nox4 and endoplasmic reticulum chaperones within lipid droplets in vascular smooth muscle cells"
|
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Aline Androwiki (University of Sao Paulo)
"Protein Disulfide Isomerase expression increases in resistance arteries during hypertension development. Effects on NADPH oxidase dependent ROS generation"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Srinivasa Raju Datla (Emory University)
"Poldip2, a Nox4 Interacting Protein, Regulates Vascular Smooth Muscle Cell Migration via RhoA-dependent Focal Adhesion Turnover" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Marcelo Montenegro (Emory University)
"Nox4 and H2O2 mediate vascular smooth muscle cell adaptation to mechanical stretch" |
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Understanding Nox Regulation Through Disease Models |
| Discussion Leader: Hitesh Peshavariya (Centre for Eye Research Australia) |
| 9:00 am - 9:15 am | Adam Nabeebaccus (King's College)
"NADPH oxidase-4 induces metabolic reprogramming in the murine heart in vivo"
|
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Silvia Trevelin (University Of Sao Paulo)
"NOX2 is essential for sepsis survival through a mechanism independent of bacterial infection control and related to the prevention of multi organ failure"
|
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Matthew Distasi (Indiana University School Of Medicine)
"Role of NAD(P)H Oxidase Mediates the Obesity-Induced Impairment of Vascular Compensation in Subcritical Limb Ischemia: Specific Role for Nox2 and p47phox subunits"
|
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Brandon Downing (Indiana University School Of Medicine)
"Monocyte/macrophages are the Primary Effectors of Nf1+/- Aneurysm Formation via Increased Activation of the NADPH Oxidase System"
|
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Marina Hernandes (University of Sao Paulo)
"Nadph oxidase and the degeneration of dopaminergic neurons in parkinsonian mice"
|
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Tamara Seredenina (University of Geneva)
"Inhibition of NOX2 as a potential treatment for amyotrophic lateral sclerosis"
|
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Discovering Treatments |
| Discussion Leader: John Woolley (University College Cork) |
| 1:30 pm - 1:45 pm | Tatiana Spadoni (Universita Politecnica Delle Marche)
"Expression profile and regulation of NOX proteins in fibrotic disorders: implication for Scleroderma"
|
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Natalie Torok (UC Davis)
"Apoptosis and fibrosis are attenuated by GKT137831 a novel NOX4/NOX1 inhibitor in an in vivo model of liver injury"
|
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Natalie Sampson (Medical University of Innsbruck)
"ROS signaling by NOX4 drives stromal remodeling in the diseased prostate"
|
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
