Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: mRNA Therapeutics
Discussion Leader: Anastasia Khvorova (University of Massachusetts Medical School, USA)
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7:40 pm - 7:45 pm |
Opening Remarks
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7:45 pm - 8:35 pm |
Melissa Moore (Moderna Therapeutics, USA)
"mRNA as Medicine"
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8:35 pm - 8:50 pm |
Discussion
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8:50 pm - 9:00 pm |
Anna Maria Kietrys (Stanford University, USA)
"Optical and Chemical Control of mRNA"
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9:00 pm - 9:05 pm |
Discussion
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9:05 pm - 9:15 pm |
Misael Romero-Reyes (Emory University, USA)
"Water Purification to Remove Small-Molecule Contaminants Using Aptamer-Functionalized Membranes"
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9:15 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Small Molecule Recognition of DNA and RNA
Discussion Leader: Jennifer Heemstra (Emory University, USA)
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9:00 am - 9:25 am |
Amanda Hargrove (Duke University, USA)
"Deciphering Patterns in Selective Small Molecule:RNA Interactions"
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9:25 am - 9:35 am |
Discussion
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9:35 am - 10:00 am |
Steven Zimmerman (University of Illinois at Urbana-Champaign, USA)
"Targeting DNA and RNA Repeats that Cause Disease with Small and Not So Small Molecules"
|
10:00 am - 10:10 am |
Discussion
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10:10 am - 10:20 am |
Dennis Bong (The Ohio State University, USA)
"The Use of Synthetic Base Triples for Probing RNA Tertiary Interactions and siRNA Delivery"
|
10:20 am - 10:25 am |
Discussion
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10:25 am - 10:55 am |
Coffee Break
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10:55 am - 11:20 am |
John Schneekloth, Jr. (National Cancer Institute, NIH, USA)
"Insights into Targeting Nucleic Acid Tertiary Structure with Small Molecules"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:55 am |
W. David Wilson (Georgia State University, USA)
"Base Pair Sequence and Minor Groove Shape in the Design of New Types of Cell-Permeable, DNA-Binding Agents"
|
11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:15 pm |
Andrea Taladriz-Sender (University of Strathclyde, United Kingdom)
"Development of Splice-Switching Molecules as Inducers of Apoptosis"
|
12:15 pm - 12:20 pm |
Discussion
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12:20 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Katherine Seley-Radtke (University of Maryland, Baltimore County, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Synthesis and Applications of Modified Oligonucleotides
Discussion Leader: Subha Das (Carnegie Mellon University, USA)
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7:30 pm - 7:55 pm |
Daniel Appella (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Cyclopentane Locked Peptide Nucleic Acids"
|
7:55 pm - 8:05 pm |
Discussion
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8:05 pm - 8:30 pm |
Eriks Rozners (Binghamton University, SUNY, USA)
"Amide-Modified RNA Synthesis, Structure and RNA Interference Activity"
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8:30 pm - 8:40 pm |
Discussion
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8:40 pm - 9:05 pm |
Ichiro Hirao (Institute of Bioengineering and Nanotechnology, A*STAR, Singapore)
"Genetic Alphabet Expansion for Xenobiology"
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9:05 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Shigeo Matsuda (Alnylam Pharmaceuticals, USA)
"Evaluation of Modified Unlocked Nucleic Acid (mUNA) on the Gene Silencing Activity of siRNA"
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9:25 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Nucleoside/Nucleotide Drug Development
Discussion Leader: Katherine Seley-Radtke (University of Maryland, Baltimore County, USA)
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9:00 am - 9:25 am |
Steven Almo (Albert Einstein College of Medicine, USA)
"The Many Faces of SAM"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Izzat Raheem (Merck, USA)
"HIV Nucleoside Reverse Transcriptase Translocation Inhibitors to Enable Extended Duration Dosing"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:20 am |
Amitava Adhikary (Oakland University, USA)
"Azido-Substituted Nucleosides as Radiation Damage Enhancement Agents"
|
10:20 am - 10:25 am |
Discussion
|
10:25 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Suzanne Peyrottes (CNRS / University of Montpellier , France)
"New Series of Acyclic Nucleoside Phosphonates as Potent Antimalarials"
|
11:20 am - 11:30 am |
Discussion
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11:30 am - 11:55 am |
Piet Herdewijn (KU Leuven, Belgium)
"Phosphonate Nucleosides and Oligonucleotides"
|
11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:15 pm |
Richard Pomerantz (Lewis Katz School of Medicine, Temple University, USA)
"Development of Nucleoside Prodrugs as Precision Medicine for BRCA-Deficient Cancers"
|
12:15 pm - 12:20 pm |
Discussion
|
12:20 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Synthetic Oligonucleotide Therapeutics
Discussion Leader: Muthiah Manoharan (Alnylam Pharmaceuticals, USA)
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7:30 pm - 7:55 pm |
Phil Baran (Scripps Research , USA)
"Aiming for Ideality in the Synthesis of Oligonucleotides"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Anastasia Khvorova (University of Massachusetts Medical School, USA)
"RNAi-Based Modulation of Gene Expression in CNS"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 9:05 pm |
Peter Glazer (Yale University, USA)
"Gene Editing by PNA Nanoparticles"
|
9:05 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Pachamuthu Kandasamy (WAVE Life Sciences, USA)
"From Stereopurity to Precision Medicine: Optimizing the Properties of Antisense Nucleic Acid Therapeutics"
|
9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Fluorescence Imaging Agents
Discussion Leader: Byron Purse (San Diego State University, USA)
|
9:00 am - 9:25 am |
Steven Magennis (University of Glasgow, United Kingdom)
"Stacking-Induced Fluorescence Increase as a Versatile Probe of DNA Structure and Dynamics"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Tirayut Vilaivan (Chulalongkorn University, Thailand)
"Cationic Styryl Dyes for Dual-Mode Colorimetric and Fluorescence Sensing of DNA"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:20 am |
Kunihiko Morihiro (The University of Tokyo, Japan)
"Live Cell Imaging of Telomerase Activity Using Hybridization-Sensitive Fluorescence Oligonucleotide Probes"
|
10:20 am - 10:25 am |
Discussion
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10:25 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Marit Nilsen-Hamilton (Iowa State University, USA)
"Employing the Functions of Aptamers Inside Cells"
|
11:20 am - 11:30 am |
Discussion
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11:30 am - 11:55 am |
Yitzhak Tor (University of California, San Diego, USA)
"Isomorphic Fluorescent Nucleosides, Nucleotides and Oligonucleotides"
|
11:55 am - 12:05 pm |
Discussion
|
12:05 pm - 12:15 pm |
Fangwei Shao (Zhejiang University, China)
"PT(BPA)2+: A Fluorogenic Probe for Real-Time Tracking of RNA Quadruplexes in Cells"
|
12:15 pm - 12:20 pm |
Discussion
|
12:20 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Nucleic Acid Structure
Discussion Leader: Danzhou Yang (Purdue University, USA)
|
7:30 pm - 7:55 pm |
Millie Georgiadis (Indiana University School of Medicine, USA)
"Hachimoji DNA: An Expanded Genetic System"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Janez Plavec (National Institute of Chemistry, Slovenia)
"Exciting Tetrahelical Structures of G-Rich DNA Repeats Beyond G-Quadruplexes"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 9:05 pm |
Deborah Wuttke (University of Colorado Boulder, USA)
"Pervasive RNA Binding by Transcription Factors"
|
9:05 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Deepak Koirala (University of Chicago, USA)
"Application of Anti-RNA Antibodies for RNA Crystallography and Beyond"
|
9:25 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Nucleic Acids Chemical Biology
Discussion Leader: Webster Santos (Virginia Tech, USA)
|
9:00 am - 9:25 am |
Tracy Brooks (Binghamton University, SUNY, USA)
"Biology and Therapeutic Potential of the MYC and kRAS Promoter G-Quadruplexes"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
David Corey (University of Texas at Dallas, USA)
"Nucleic Acids and the Control of Gene Expression in Cell Nuclei"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:20 am |
Ralph Kleiner (Princeton University, USA)
"Chemical Approaches to Illuminate the Epitranscriptome"
|
10:20 am - 10:25 am |
Discussion
|
10:25 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Naoki Sugimoto (FIBER, Konan University, Japan)
"The Watson-Crick World Is Not Enough"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:55 am |
Danith Ly (Carnegie Mellon University, USA)
"Design of Bivalent Nucleobases for Targeting Double-Stranded DNA and RNA"
|
11:55 am - 12:05 pm |
Discussion
|
12:05 pm - 12:15 pm |
Jonathan Sczepanski (Texas A&M University, USA)
"Heterochiral DNA Circuitry: Interfacing Oligonucleotide Enantiomers in Living Cells"
|
12:15 pm - 12:20 pm |
Discussion
|
12:20 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
DNA Modification and Repair
Discussion Leader: Natalia Tretyakova (University of Minnesota, USA)
|
7:30 pm - 7:40 pm |
Kabirul Islam (University of Pittsburgh, USA)
"An Orthogonal Chromatin Landscape for Transcriptional Reprogramming"
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 8:10 pm |
Sarah Delaney (Brown University, USA)
"DNA Repair in Nucleosomes"
|
8:10 pm - 8:20 pm |
Discussion
|
8:20 pm - 8:45 pm |
Patricia Opresko (University of Pittsburgh, USA)
"The Impact of Oxidative DNA Base Damage on Telomere Maintenance"
|
8:45 pm - 8:55 pm |
Discussion
|
8:55 pm - 9:20 pm |
Cynthia Burrows (University of Utah, USA)
"Base Modifications at the Intersection of DNA Repair and Gene Expression"
|
9:20 pm - 9:30 pm |
Discussion
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|