Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Chromatin Regulation by RNA Methylation
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Gaining New Perspectives on Chromatin Interactions Through Heterotypic Nucleosomes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:00 pm
"Nucleic Acids Chemical Labeling"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemistry of Modified Nucleosides and Nucleotides
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Cyclic Oligonucleotides- Fascinating Molecules and New Therapeutic Opportunities"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"New Strategies and Tactics for the De Novo Synthesis of Nucleosides and Nucleoside Analogues"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Chemistry of Modified Nucleosides and Nucleotides"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"3'-Deoxy-3',4'-Didehydro-Nucleosides and ProTides as Potent Antiviral Agents"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Structure and Function
7:30 pm - 7:55 pm
"RNA Switches in Viral and Human Genomes: Uncovering Hidden Regulatory Elements"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Expand the Alphabet and Topology of Synthetic mRNAs for Therapeutics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Structure-Based Discovery and Manipulation of New Functions in Large RNAs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Non-Canonical Structures of Nucleic Acids
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"CUT&Tag Genome-Wide Mapping in Mycobacterium Tuberculosis Reveals an Unconventional G-Quadruplex Landscape"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"G-Quadruplex-Forming Aptamers for Biomedical Applications"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"G4 RNA Structures and Their Contribution to Stress Response"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Drug Targeting and Protein Recognition of Oncogene DNA G-Quadruplex"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis and Sequencing of Native and Modified Oligonucleotides
7:30 pm - 7:55 pm
"RNA Direct Nanopore Sequencing Reveals Chemical Changes to Cellular rRNA During Stress"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Enzymatic De Novo Synthesis of 1000-Mer Oligonucleotides"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"RNA Oligonucleotide Manufacturing Using Engineered Enzymes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Chemistry for Therapeutics, Probes, and Model Systems
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Click to Control RNA Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Design of Fluorogenic Probes for RNA Sensing and Imaging: Small Molecules, Triplex-Forming Peptide Nucleic Acids and Light-Up Peptides "
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Base-Modified and Hypermodified DNA, RNA and XNA for Chemical Biology and Selection of Functional Nucleic Acids"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"All About "To B or Not To B " in Nucleic Acids Chemistry"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CRISPR DNA and ADAR RNA Editing
7:30 pm - 7:55 pm
"Development and Characterization of Precision Genome Editing Tools"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Exploring the Evolution of RNA-Guided Systems Towards the Development of Molecular Tools"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Therapeutic Applications for Hepatic and Extrahepatic RNA Editing via Endogenous ADAR Enzymes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Nucleic Acid Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Chemical Engineering of RNA Therapeutics for CNS Manipulation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"We Need New Chemistry to Address the Endosomal Escape Problem"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Structure-Based Approach to Drugging RNA with Small Molecules"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Modifications of mRNA Ends to Boost mRNA Therapeutics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology of Modified Oligonucleotides
7:30 pm - 7:55 pm
"The Origin of Biomolecules on the Early Earth"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Nucleic Acid Chemistry with Light"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Chemical Sensing and Biological Regulation by Riboswitches"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure