Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Methods for Complex Molecule Synthesis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"The Original Cope Rearrangement: Fundamental Studies and Applications in Complex Molecule Synthesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"The Concept of Delayed Catalysis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Function-Oriented Synthesis: The Role of Design and Step/Time Economical Syntheses in Strategies for HIV/AIDS Eradication, Alzheimer's Disease and Cancer Immunotherapy"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transition Metal Catalyzed Methods
9:00 am - 9:30 am
"Developing Catalytic Reactions One Step at a Time"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Exploiting a Native Directing Group: Catalytic, Regioselective C-H Arylation in the Synthesis of IKur Inhibitor, BMS-919373"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"A Synergistic Strategy to Achieve an Asymmetric Pauson-Khand Reaction Using Iterative Synthetic Chemistry and Quantum Mechanics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Rational Design of Precatalysts for Cross-Coupling and Related Reactions"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Hypervalent Iodine Methods
7:30 pm - 8:00 pm
"Towards Iterative Iodane-Directed C-H Functionalization of Arenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Hypervalent Iodane Mediated Halogenations: A Versatile Tools for the Exploration of Novel Reactivities"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Development of a Biomimetic Approach to MK-8591"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Process Improvements for Drug Development
9:00 am - 9:30 am
"Upadacitinib: Process Development of a JAK1 Inhibitor"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Development of a Biocatalytic Route to the SMO Inhibitor Glasdegib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Development of a Manufacturable Route for BACE Inhibitor LY3202626"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"ChemPager and How to Make 37 kg of RG7834"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Use of Biomimetic Methods in Synthesis
7:30 pm - 8:00 pm
"Stereoselective Catalysis with Peptides"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Advancing Cost Effective Iridium C-H Borylations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Recent Progress on Catalytic Asymmetric Dearomatization (CADA) Reactions"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Single Electron Processes Enabling Organic Synthesis"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Alcohol and Amine Derivatives Guide Position-Selective C-H Functionalization Reactions"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Novel and Versatile BI-Ligands for Practical Synthesis of APIs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Synthesis of Complex Molecules
7:30 pm - 8:00 pm
"Recent Synthetic Achievements in the Smith Group at the University of Pennsylvania"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Recent Efforts in the Synthesis of Complex Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Necessity Is the Mother of Invention: Natural Products and the Chemistry They Inspire"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereoselective Methods for Synthesis
9:00 am - 9:30 am
"De Novo Asymmetric Natural Product Synthesis: Application to Stereochemical-Structure Activity Relationship (S-SAR) Studies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Stereospecific Pd-Catalyzed Cross-Coupling Reactions Using Enantioenriched Nucleophiles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Development of an Asymmetric Synthetic Process to the IDO Inhibitor Navoximod"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"13C Kinetic Isotope Effects Reveal Mechanism of Catalytic Suzuki-Miyaura Coupling (SMC) Reactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Biocatalytic Methods for the Enantioselective Synthesis of Diamines"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Radical Atom-Transfer Methods Mediated by Phosphorus(III) Reagents"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Design of Novel Methodology
7:30 pm - 8:00 pm
"Rational Design of High-Performance Catalysts Based on Acid-Base Combination Chemistry"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Decarboxylative Substitution and Elimination Reactions"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
"The History, Chemistry and Biology of Taxol, a Famous Anticancer Natural Product"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure