Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stereochemical and Atomic Control in Organic Synthesis
Discussion Leader: Mark Biscoe (The City College of New York, USA)
7:40 pm - 8:10 pm
Qiu Wang (Duke University, USA)
"Copper-Catalyzed Aminofunctionalization of Alkenes and Dienes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
David Lupton (Monash University, Australia)
"Polarity Inversion Catalysis by the Conjugate Addition of Lewis Bases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Cathleen Crudden (Queen's University, Canada)
"Catalyst Development from Pico to Nano–Cross Coupling Reactions of Sulfones and Novel Nano Cluster Catalysts"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Installation and Uses of Halogens
Discussion Leader: Florence Williams (University of Iowa, USA)
9:00 am - 9:30 am
Rebecca Green (Bristol Myers Squibb, USA)
"Design and Development of a Convergent Synthesis of an Aminoquinoline NLRP3 Agonist"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Mark Kerr (Eli Lilly and Company, USA)
"Development of a Palladium-Catalyzed Aryl Amidation for API Synthesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
Megan Smyth (Almac Group, United Kingdom)
"Technology Solutions to Unlock Access to Challenging Reactions on Scale"
11:05 am - 11:10 am
Discussion
11:10 am - 11:45 am
Tobias Ritter (Max Planck Institute KoFo, Germany)
"Late-Stage Functionalizations"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
Beate Koksch (Freie Universitat Berlin, Germany)
"Fluoropeptides as Biodegradable Biopolymers"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Jennifer Heemstra (Emory University, USA) and Emma McInturff (Pfizer, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Strategies in C-C Bond Formation
Discussion Leader: Erin Stache (Cornell University, USA)
7:30 pm - 8:05 pm
Debabrata Maiti (IIT Bombay, India)
"En-Light-Ening C–H Functionalization"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Sarah Wengryniuk (Temple University, USA)
"Site Selective Synthesis of Benzylic Collidinium Salts via Electrochemical C–H Functionalization"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Chulbom Lee (Seoul National University, South Korea)
"Alkyne Functionalization for Use in Organic Synthesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteins and Similars
Discussion Leader: Sebastien Laulhe (Indiana University-Purdue University Indianapolis, USA)
9:00 am - 9:30 am
Emma McInturff (Pfizer, USA)
"Process Development of Paxlovid: Milligrams to Metric Tons in 18 Months"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Jie Xu (Genentech Inc., USA)
"Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant)"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
Sara Bonderoff (Gilead Sciences, USA)
"How a Crystallization Induced Dynamic Resolution Made Lenacapavir Possible"
11:05 am - 11:10 am
Discussion
11:10 am - 11:45 am
Samuel Gellman (University of Wisconsin-Madison, USA)
"Catalysis with Foldamers"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
Jennifer Heemstra (Emory University, USA)
"High-Throughput Enantiopurity Analysis using Enantiomeric DNA-Based Sensors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Behold the Power of Light
Discussion Leader: Yalan Xing (William Paterson University of New Jersey, USA)
7:30 pm - 8:05 pm
David Nicewicz (University of North Carolina at Chapel Hill, USA)
"New Avenues in Synthesis via Organic Photoredox Catalysis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Abigail Doyle (UCLA, USA)
"Nickel-Catalyzed Cross Coupling: New Tools and Methods for Chemical Synthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Ryan Gilmour (Universitat Muenster, Germany)
"Illuminating Alkene Isomerization"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
More C-C Bond Formation and Methods
Discussion Leader: Michael Harmata (University of Missouri-Columbia, USA)
9:00 am - 9:30 am
Jessica Herrick (Corteva Agriscience, USA)
"Discovery Process for a Cereal Fungicide"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Nadine Kuhl (Merck & Co., Inc., USA, USA)
"Converting a Biorenewable Solvent into an Active Pharmaceutical Ingredient"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
Joyce Leung (Boehringer Ingelheim Pharmaceuticals, Inc., USA)
"Development of Stereoselective and Scalable Syntheses Toward Key Building Blocks for Potential Drug Candidates"
11:05 am - 11:10 am
Discussion
11:10 am - 11:45 am
Hongli Bao (Fujian Institute, China)
"Asymmetric Outer-Sphere Radical Reactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
Thomas Snaddon (Indiana University, USA)
"Enantioselective Chemical Synthesis Methods via Cooperative Catalysis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Let the Chemistry Flow
Discussion Leader: Silas Cook (Indiana University, USA)
7:30 pm - 8:05 pm
Jason Hein (University of British Columbia, Canada)
"Understanding, Improving and Controlling Processes by Realtime HPLC"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
Timothy Noel (University of Amsterdam, The Netherlands)
"Innovation in Photocatalysis through Use of Fow"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Timothy Jamison (Massachusetts Institute of Technology, USA)
"Synthesis Design through the Lens of Flow Chemistry"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reactions in Motion
Discussion Leader: Michael Zacuto (Briston Meyers Squibb, USA)
9:00 am - 9:35 am
Robert Flowers (Lehigh University, USA)
"Unraveling the Mechanism of Electron Transfer from Samarium(II)-Proton Donor Complexes."
9:35 am - 9:40 am
Discussion
9:40 am - 10:15 am
Oliver Kappe (University of Graz, Austria)
"Adventures in Flow Chemistry – Towards Continuous Manufacturing of APIs"
10:15 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Mary Russell (Snapdragon Chemistry, USA)
"Accelerating Process Development with Automated Continuous Reactions and Online LC"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemistry on Complex Molecules
Discussion Leader: Craig Merlic (University of California, Los Angeles, USA)
7:30 pm - 8:00 pm
John Jasper (Nature's Fingerprint / MIT LLC, USA)
"The Use of Natural-Abundance Stable Isotopes in Process Understanding - From Analysis to Synthesis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:40 pm
Lukas Goossen (Ruhr Universitat Bochum, Germany)
"New Catalysts and Concepts for C-C and C-Heteroatom Bond Formation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
Jeff Johnson (University of North Carolina, USA)
"Stereoselective Synthesis in Stereochemically Fluxional Systems"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure