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Parkinson's Disease

Gordon Research Conference

Proteins, Pathway, and Pathophysiology in Parkinson’s

May 7 - 12, 2023

Chair Malu G. Tansey

Vice Chairs Alexandra B. Nelson

Contact Chairs

Les Diablerets Conference Center

Eurotel Victoria

Les Diablerets, VD, Switzerland

Venue and Travel Information

Conference Description

The Parkinson's Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Parkinson's Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Matching Therapies to Disease Discussion Leader: J. Timothy Greenamyre (Pittsburgh Institute for Neurodegenerative Diseases, United States)
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:50 pm	Glenda Halliday (University of Sydney, Australia) "What's Special About Parkinson's Disease - Are Common Molecular Mechanisms Important?"
8:50 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Complex Genetics of Parkinsonism and Related Disorders Discussion Leader: Irit Rappley (Recursion, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Sonja Scholz (National Institutes of Health, United States) "Genetics Contribution to Lewy Body Dementia"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Huw Morris (UCL, United Kingdom) "Genetics of Progressive Supranuclear Palsy and Related Conditions"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	Wilma van de Berg (AmsterdamUMC, Vrije University Amsterdam, The Netherlands) "The Composition and Heterogeneity of Alpha-Synuclein Pathologies in the Human Brain"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Sara Bandres Ciga (NIH, United States) "The Genetics of Parkinson’s Disease in Diverse Ancestry Populations"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Mina Ryten (University College London, United Kingdom) "Dissecting Parkinson's Disease with Long-Read RNA-Sequencing"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Alice Chen-Plotkin (University of Pennsylvania, United States) "How Do We Get from GWAS Locus to Therapeutic Target in Parkinson's Disease?"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Group Photo / Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Alexandra Nelson (University of California, San Francisco, United States) and Shalini Padmanabhan (The Michael J. Fox Foundation for Parkinson's Research, United States)
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Physiology of Non-Motor Systems Relevant To PD Discussion Leader: Benjamin Wolozin (Boston University School of Medicine, United States)
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:30 pm	Michael Burton (The University of Texas at Dallas, United States) "Sensory Neuron TLR4 Mediates Gut Inflammation and CNS Immune Activation"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:00 pm	Karen Gamble (University of Alabama at Birmingham, United States) "Disruption of Circadian Rhythmicity in Neurodegenerative Disorders"
7:00 pm - 7:10 pm	Discussion
7:10 pm - 7:30 pm	Yang Dan (University of California, Berkeley, United States) "Monoaminergic Neurons in Sleep and Parkinson's Disease"
7:30 pm - 7:40 pm	Discussion
7:40 pm - 7:50 pm	Deanna Benson (Icahn School of Medicine at Mount Sinai, United States) "Lrrk2^G2019S Alters Development and Stress-Dependent Recruitment of Brain-Wide Networks in Mice"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Non-Nigral and Mixed Pathology in PD Discussion Leader: Alexandra Nelson (University of California, San Francisco, United States)
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	Lorraine Kalia (University of Toronto, Canada) "Pathological Substrates of LRRK2-Related Parkinson's Disease"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	Le Zhang (Yale University, United States) "Autoimmunity in Prodromal Parkinson's Disease"
10:00 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 11:00 am	Michael Henderson (Van Andel Institute, United States) "Cortical Vulnerability to Protein Pathologies"
11:00 am - 11:10 am	Discussion
11:10 am - 11:30 am	Caleb Webber (UK Dementia Research Institute, United Kingdom) "The Genetics Influencing the Risk of Parkinson's Disease Onset and How Parkinson's Disease Manifestations are Distinct"
11:30 am - 11:40 am	Discussion
11:40 am - 12:00 pm	Rimona Weil (UCL Institute of Neurology, United Kingdom) "Using Vision to Understand Dementia in Parkinson’s Disease"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Rebecca Zack (University of Pennsylvania, United States) "Plasma a-Synuclein Strains in Lewy Body Disease"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Vesicular Sorting Discussion Leader: Sabine Hilfiker (Rutgers New Jersey Medical School, United States)
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:30 pm	Darren Moore (Van Andel Institute, United States) "Retromer Dysfunction in Parkinson's Disease"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:00 pm	Sreeganga Chandra (Yale University, United States) "Synaptic Vesicle Endocytosis Deficits in Parkinson's Disease"
7:00 pm - 7:10 pm	Discussion
7:10 pm - 7:30 pm	Hilal Lashuel (École Polytechnique Fédérale de Lausanne, Switzerland) "Contribution of Synuclein Species to Pathology"
7:30 pm - 7:40 pm	Discussion
7:40 pm - 7:50 pm	Anusha Kamesh (McGill University, Canada) "Progressive Emergence of Alterations in Striatal Glutamate and Dopamine Neurotransmission in the VPS35 D620N Knock-in Mouse Model of PD"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Lysosomal Function Discussion Leader: Darren Moore (Van Andel Institute, United States)
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	Peter Vangheluwe (KU Leuven , Belgium) "A Role for ATP13A2 Deficiency in Lysosomal Dysfunction"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	Monther Abu-Ramaileh (Stanford University, United States) "Lysosomal Dysfunction in Neurodegenerative Diseases: From Tool Development to Novel Biology"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Bruno Benitez (Harvard Medical School - Beth Israel Deaconess Center, United States) "Effect of LRRK2 on PGRN, CTSD, GPNMB, and Processing of Pathological Alpha-Synuclein in Myeloid Cells"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Matthew LaVoie (University of Florida, United States) "Impact of GBA1 and LRRK2 Mutations on Lysosome Function"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Aimee Kao (University of California, San Francisco, United States) "Aging, Cathepsins and Targeted Clearance of Alpha-synuclein in the Lysosome"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Shawn Ferguson (Yale University School of Medicine, United States) "LRRK2: A Brake for When Lysosomes Break"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Neuroinflammation and Glial Cell Interactions Discussion Leader: Matthew LaVoie (University of Florida, United States)
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:30 pm	Shane Liddelow (NYU Grossman School of Medicine, United States) "The Function of Reactive Astrocyte Sub-states in Neurodegenerative Disease"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:00 pm	Max Gutierrez (The Francis Crick Institute, United Kingdom) "Macrophages: At the Crossroads Between Infection and Neurodegeneration"
7:00 pm - 7:10 pm	Discussion
7:10 pm - 7:30 pm	Ashley Harms (University of Alabama at Birmingham, United States) "Synuclein-Mediated Neuroinflammation in PD Models"
7:30 pm - 7:40 pm	Discussion
7:40 pm - 7:50 pm	Phillip Mackie (University of Florida College of Medicine, United States) "Myenteric Macrophages Protect Against the Spread of Gut Synucleinopathy"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Cellular and Intracellular Parkinson’s Disease Pathways Discussion Leader: Peter Vangheluwe (KU Leuven , Belgium)
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	Luis Bonet-Ponce (National Institues of Health (NIH)/ National Institue of Aging (NIA), United States) "LRRKing on Lysosomes: Understanding LRRK2's Role in Lysosomal Biology"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	Rebecca Wallings (university of florida, United States) "LRRK2 as a Regulator of Immune and Inflammatory Responses via the Lysosome: Lessons from Mice and Men"
10:00 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 11:00 am	Miratul Muqit (University of Dundee, United Kingdom) "New Insights Into the PINK1 Pathway in Parkinson's Disease"
11:00 am - 11:10 am	Discussion
11:10 am - 11:30 am	Lindsay De Biase (UCLA, United States) "Microglial Mitochondria and Selective Neuron Vulnerability"
11:30 am - 11:40 am	Discussion
11:40 am - 12:00 pm	Sabine Hilfiker (Rutgers New Jersey Medical School, United States) "Distinct Roles of Rab Proteins in LRRK2 Pathogenesis"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Eduardo Albornoz (The University of Queensland, Australia) "Therapeutic Targeting of Inflammasome Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) to Slow Disease Progression in Parkinson’s Disease"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Emerging Topics in Neurodegeneration Discussion Leader: Shalini Padmanabhan (The Michael J. Fox Foundation for Parkinson's Research, United States)
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:30 pm	Benjamin Wolozin (Boston University School of Medicine, United States) "The Role of Stress Granules in Neurodegenerative Diseases"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 6:55 pm	Talk Selected from GRS
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	Arpine Sokratian (Duke University, United States) "Anionic Nanoplastic Contaminants Promote a-Synuclein Aggregation in Neurons"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Madalynn Erb (Van Andel Research Institute, United States) "Adult-Onset Knockout of ATP13A2 in the Mouse Ventral Midbrain Disrupts Lysosomal Biology and Causes Progressive Degeneration of Substantia Nigra Dopamine Neurons"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Nora Bengoa-Vergniory (Achucarro Basque Center for Neuroscience, University of Oxford, Spain) "REST as a Neuroprotective Factor for Parkinson's Disease"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Sandhya Kortagere (Drexel University College of Medicine, United States) "Glutamate Dysregulation Promotes Impulsive Behaviors in a Rodent Model of Parkinson’s Disease"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

“Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS124315. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

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