1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Keynote Session: Pattern-Based Image Analysis: Insights into PD Mechanisms
Tara Diviney (University of Oxford, United Kingdom)
3:15 pm - 3:50 pm
Vesna Sossi (University of British Columbia, Canada) "Pattern-Based Image Analysis: Insights into PD Mechanisms"
3:50 pm - 4:00 pm
4:00 pm - 5:30 pm
5:30 pm - 7:30 pm
Parkinson's Pathology: Molecular, Cellular, and Circuit Dysfunction in Parkinson's Disease
Kyle Farmer (University of Pittsburgh, United States)
5:30 pm - 5:45 pm
Daniel Albaugh (Carnegie Mellon University, United States) "Basal Ganglia Outflow to the Pedunculopontine Nucleus in Healthy and Parkinsonian Mice"
5:45 pm - 5:50 pm
5:50 pm - 6:05 pm
Meghan Bucher (Columbia University, United States) "Therapeutic Targeting of Synaptic Vesicle Glycoprotein 2C (SV2C) in Parkinson's Disease"
6:05 pm - 6:10 pm
6:10 pm - 6:25 pm
Haley Geertsma (University of Ottawa, Canada) "Constitutive Nuclear Accumulation of Endogenous Alpha-Synuclein in Mice Causes Motor Dysfunction and Cortical Atrophy, Independent of Protein Aggregation"
6:25 pm - 6:30 pm
6:30 pm - 6:45 pm
Aurelia Watson (University College London, United Kingdom) "The Impact of Lipid Droplets on Alpha-Synuclein Protein Folding and Aggregation Propensities in Parkinson’s Disease."
6:45 pm - 6:50 pm
6:50 pm - 7:05 pm
Silas Buck (University of Pittsburgh, United States) "Transcriptomic Analysis of Vesicular Glutamate Transporter-Expressing Dopamine Neurons Reveals Differential Expression of Genes Mediating Vulnerability to Neurodegeneration"
7:05 pm - 7:10 pm
7:10 pm - 7:25 pm
Ananya Swaroop (University of Alabama at Birmingham, United States) "Rhythmic Gene Expression in the Substantia Nigra and Ventral Tegmental Area Dopaminergic Neurons and the Impact of PFFs on the Dopaminergic Molecular Clock"
7:25 pm - 7:30 pm
8:00 pm - 9:00 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Multidimensional Immune Interactions in Parkinson's Disease
Jacob Howe (Michigan State University, United States)
9:00 am - 9:15 am
Zena Chatila (Columbia University, United States) "Using Microglial and Immune Cell Signatures from Single-Nucleus Profiling to Identify Neuroimmune Interactions and Therapeutic Targets for Parkinson Disease"
9:15 am - 9:20 am
9:20 am - 9:35 am
Katrina (Albert) Räty (University of Eastern Finland, Finland) "Effects of Alpha-Synuclein Fibrils on Human Microglia in Adult Mouse Brain"
9:35 am - 9:40 am
9:40 am - 9:55 am
Georgios Tsafaras (KU Leuven, Laboratory for Neurobiology and Gene Therapy, Belgium) "Mutant LRRK2 Exacerbates Immune Response and Neurodegeneration in a Chronic Model of Experimental Colitis"
9:55 am - 10:00 am
10:00 am - 10:15 am
Amandine EVEN (Université de Montréal, Canada) "Comparison of the Ability of the Pathogen-Associated Molecular Patterns LPS and Poly(I:C) to Trigger Parkinson’s Disease-Like Pathology in Pink1 and Parkin KO Mice"
10:15 am - 10:20 am
10:20 am - 10:35 am
Harrison Waters (The University of Melbourne, Australia) "The Gut-Brain Axis and Parkinson’s Disease: Are Type-I Interferons the Link?"
10:35 am - 10:40 am
10:40 am - 10:55 am
Kainat Akhtar (Albany Medical College, United States) "Using Non-Invasive Focused Ultrasound to Mitigate Alpha Synuclein Propagation in a Parkinson’s Disease Rat Model"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Parkinson's Up Close: A Patient's Perspective / Mentorship Panel
Malu Tansey (University of Florida College of Medicine, United States) and Alexandra Nelson (University of California, San Francisco, United States)
1:30 pm - 1:50 pm
Richelle Flanagan (My Moves Matter, Ireland) "Parkinson's Up Close: A Patient's Perspective"
1:50 pm - 2:00 pm
2:00 pm - 2:30 pm
Mentorship Panel: “What Comes Next?” Constructing a Path to Independence
Mark Cookson (National Institute on Aging, NIH, United States)
Nicole Polinski (The Michael J. Fox Foundation, United States)
Ekemini Riley (Coalition for Aligning Science (CAS), United States)
Jacob Marcus (Merck Sharp & Dohme (MSD), United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)