Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Cell Biology of Phagocytes and Phagocytosis
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Solute Flow and Flux in Phagocytes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Phagocytosis from the Perspective of Viruses: Mechanisms and Manipulation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte Ontogeny and Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Biochemical and Biomechanical Regulation of Myeloid Cell Development and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Phagocyte-Mediated Regulation of Hematopoiesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Nuclear Body Formation During Inflammatory Stimulation of Macrophages"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:10 am
"Systemic Cytokines Drive Conserved Severity-Associated Myeloid Responses across Bacterial and Viral Infections"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Circadian Checkpoints of Neutrophils"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Investigation of Hepatic Neutrophil Heterogeneity in a Murine Model of Metabolic Dysfunction-Associated Steatohepatitis (MASH)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Roles of Sex Chromosomes and Gonadal Hormones in Monocyte and Macrophage Sex Dimorphism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Life and Death of Phagocytes
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Decoding the Response to Cell Death"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Monocyte Cell Death Following Uptake of Atherogenic Lipids is Controlled by Endogenous Lipid Biogenesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Effects of Hyperactivating Mutations in Rac on Development, Immunity, and CAR-M"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Proteostasis Maintenance by Macrophage Trogocytosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Activation and Activities of Phagocytes
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Endolysosomal Trafficking and Function in Phagocyte-Mediated Inflammation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Macrophage TIFAsome-Dependent Control of Inflammation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"PSTPIP2 Regulates Degranulation of Primary Granules and IL-1b Release in Neutrophils"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Structural Basis for NOX2 Assembly and Switch to Active State"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Staphylococcus aureus Alpha-Toxin Impairs Early Neutrophil Localization and Clustering via Electrogenic Disruption of Store-Operated Calcium Entry"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Lysosomal Solute Carriers Control Phagosomal Inflammatory Signaling and Autophagy in Dendritic Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Naturally Occurring Kindlin-3 Splicing Variant Enhances Membrane Binding and Supports Neutrophil Adhesion"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Quantitative Approaches to Phagocyte Functionality
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Mechanoregulation of Myeloid Cell Phagocytosis and Decision-Making"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Metabolic Interaction Between Neisseria gonorrhoeae and Neutrophils"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Mathematical Modeling of the Neutrophil Response to Aspergillus"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Neutrophil Migration to Chemotactic Cues"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Messy Eaters: Mechanisms of Trogocytic Membrane Exchange in Macrophages"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte-Microbe Interactions
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Imaging the Host-Pathogen Interface In Vivo Using Zebrafish"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Give and Take: The Intricate Lipid Interface Between Mycobacteria and their Phagocyte Host"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Type 1 Conventional Dendritic Cells Do Not Serve as a Replicative Niche for Listeria monocytogenes "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"How Mycobacterium Tuberculosis Subverts Phagocyte Function"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Use of Dual Genetics to Dissect How Yersinia Yops Collaborate to Block Neutrophil Functions"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Inhibition of NADPH Oxidase 2 Improves Survival in Zebrafish Infected with Influenza A Virus"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Platelet Factor 4 Increases Clearance of Klebsiella pneumoniae and Reduces Lung and Liver Injury Induced by Infection in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes in Their Native Environments
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Sex-Specific Regulation of Astrocyte Density and Function by Microglia During Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Clustered Macrophages Cooperate to Eliminate Solid Tumors via Coordinated Intrudopodia"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Single Cell RNA Sequencing Reveals Dynamic Functions of Myeloid Cells During Prevotella-Induced Airway Clearance of Streptococcus pneumoniae "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Exploring the Interplay Between Host and Parasite During Entamoeba histolytica Trogocytosis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Calpain Inhibition Restores Ezrin-Dependent Survival and Immune Function in Cystic Fibrosis Alveolar Macrophages"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Phagocytes in Inflammation
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Metabolic Control of Inflammasome Activation in Macrophages"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Regulation of Phagosome Signaling by Non-Canonical Autophagy in Macrophages"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Cytosolic Nucleic Acid Sensors Mediate Antimicrobial and Inflammatory Responses of Primary Osteoblasts and Osteoclasts to Staphylococcal Osteomyelitis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"IgE-Mediated Allergic Disease Promotes Differential Monocyte Phenotypes and Functions"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Macrophage Efferocytosis in Inflammation Resolution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Legacy of Neutrophils: LAND-Vs (Large Aging Neutrophil Derived Vesicles)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulated Cell Death, Inflammation, and Stress: A Cellular Conversation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes in Homeostasis and Remodeling
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Macrophages: Obligatory Players in the Pro-Metastatic Tumor Microenvironment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Identification of Myeloid PKC Epsilon as a Novel Atheroprotective Gene"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Efferocytosis Controls Dec1/bhlhe40 for the Resolution of Inflammation During Skeletal Muscle Regeneration"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Resolution of Post-Lung Transplant Injury via MerTK-Dependent Efferocytosis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Mechanisms of Necrotic Cell Debris Clearance at Injury Sites"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure