Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Bridging Mechanisms of Extracellular Proteolysis with Novel Therapeutic Strategies for Disease
Discussion Leader: Sidney Strickland (The Rockefeller University, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:40 pm
Francis Castellino (University of Notre Dame, USA)
"The Plasminogen Activation System: The More We Learn, The Less We Understand"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Nicola Mutch (University of Aberdeen, United Kingdom)
"Cellular Elements of the Fibrinolytic System"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteases in Cardiovascular Disease and Thrombotic Disorders
Discussion Leaders: James Luyendyk (Michigan State University, USA) and Drevon Dobson (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Zsuzsa Bagoly (University of Debrecen, Hungary)
"Markers of Fibrinolysis Predicting Outcomes in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Katherine Hajjar (Weill Cornell Medicine, USA)
"Annexin A2 Deficiency in Venous Thromboembolism"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Christian Kastrup (University of British Columbia, Canada)
"RNA Gene Therapies for Enhancing Fibrinolysis and Decreasing Thrombosis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Paul Kim (Thrombosis and Atherosclerosis Research Institute (TaARI), Canada)
"Regulation of Fibrinolysis on Platelets: The Nitty Gritty Details"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Yuko Suzuki (Hamamatsu University School of Medicine, Japan)
"Spatiotemporal Regulation of TAFI Activation, Plasminogen Activation, and Fibrinolysis by Thrombin"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Ruby Law (Monash University, Australia) and Li Zhang (University of Maryland School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Metabolic Disease and Aging
Discussion Leaders: Dudley Strickland (University of Maryland School of Medicine, USA) and Stella Tsirka (Stony Brook University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Lauren Poole (Michigan State University, USA)
"Novel Mechanisms Linking Coagulation Factors to Liver Fibrosis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Delphine Meynard (INSERM, France)
"A New Role for Fibrinogen in Iron Homeostasis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Erica Sparkenbaugh (UNC Chapel Hill, USA)
"Tipping the Balance – Inducing Protective PAR-1 Signaling in Sickle Cell Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ze Zheng (Medical College of Wisconsin, USA)
"A Novel Function of tPA in Limiting apoB-VLDL Assembly in Hepatocytes"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteases in Infection and Immunity
Discussion Leaders: Shaun Lee (University of Notre Dame, USA) and Lindsey Miles (Scripps Research Institute, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Colin Kretz (McMaster University, Canada)
"Investigating the Regulation of ADAMTS13"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ana Flores-Mireles (University of Notre Dame, USA)
"Microbial Pathogens Target the Fibrinolytic Pathway to Persist in the Bladder During Catheter-Associated Urinary Tract Infection"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Lisa Gralinski (University of North Carolina at Chapel Hill, USA)
"Plasminogen Protects From Severe COVID-19 in a Mouse Model of SARS-CoV-2 Infection"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Silvio Antoniak (The University of North Carolina at Chapel Hill, USA)
"Coagulation Proteases and Their Receptors in Viral Infections"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Grant Blouse (Catalyst Biosciences, USA)
"The Structure/Function of Protease Complement Factor I and Implications for Infectious Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Cancer and Cell Signaling
Discussion Leaders: Michael Ploug (Rigshospitalet, Denmark) and Irit Sagi (Weizmann Institute of Science, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Toni Antalis (University of Maryland School of Medicine, USA)
"The Membrane Anchored Serine Protease (MASP) Testisin/PRSS21 in Microvascular Endothelial Cells and Angiogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Joseph Palumbo (Cincinnati Children's Hospital Medical Center, USA)
"Fibrinogen/Integrin Interactions and Tumor Cell Metastasis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
karin list (Wayne State University school of Medicine, USA)
"TMPRSS13 and Cancer Progression"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Virginia Metrangolo (University of Copenhagen, Denmark)
"Novel Dual-Mechanistic Antibody-Drug Conjugates for Targeting the Urokinase Receptor in Cancer"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Technologies and Therapeutic Advances in Extracellular Proteolysis
Discussion Leaders: Steven Gonias (UCSD, USA) and Wen Dai (Versiti Blood Center of Wisconsin, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Iris Kassem (Medical College of Wisconsin Eye Institute, USA)
"Non-Vascular Use of Tissue Plasminogen Activator in the Eye"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Luisa Iruela-Arispe (Northwestern University, USA)
"Endothelial-Myeloid Collaborations in Hemostasis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christopher Barrett (Massachusetts Institute of Technology, USA)
"Fibrinolysis and Thrombolytic Therapy in COVID-19 Respiratory Failure"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Christoph Hagemeyer (Monash University, Australia)
"Smart Nanomedicine for the Delivery of Plasminogen Activators"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Proteases in Tissue Remodeling and Regeneration
Discussion Leaders: Francesca Ferraresso (University of British Columbia, Canada) and Thomas Bugge (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 7:50 pm
Ulrich auf dem Keller (Technical University of Denmark, Denmark)
"Protease Network Degradomics in Skin Homeostasis and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wendy Campana (University of California, San Diego VA and the San Diego VA Healthcare System, USA)
"tPA, Neural Progenitor Cells, and Nerve Injury"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andrey Komissarov (University of Texas Health Center At Tyler, USA)
"Molecular Interactions in Fibrinolysis in Acute and Chronic Pleural Injury"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Phillip Owens (University of Cincinnati, USA)
"Coagulation Proteases in the Pathogenesis of Abdominal Aortic Aneurysm"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteases in Neurological and Cerebrovascular Disease
Discussion Leaders: Jonathan Schoenecker (Vanderbilt University Medical Center, USA) and Lakmali Silva (National Institute of Dental and Craniofacial Research, NIH, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Eric Mullins (Cincinnati Children's Research Foundation, USA)
"Plasminogen Activation in Neuroinflammatory Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Elisabetta Mantuano (University of California, San Diego, Italy)
"Non-Pathogenic Cellular Prion Protein Activates Cell-Signaling via the Tissue-Type Plasminogen Activator Receptor Assembly"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Manuel Yepes (Emory University, USA)
"Urokinase-Type Plasminogen Activator in the Pathogenesis of Alzheimer’s Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Erin Norris (Rockefeller University, USA)
"Role of Fibrinogen in Alzheimer's Disease Pathophysiology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jae Kyu Ryu (University of California, San Francisco, USA)
"Fibrinogen and B Cell Lymphoma in the Central Nervous System"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Trauma
Discussion Leaders: Daniel Lawrence (University of Michigan, USA) and Dafna Groeneveld (Michigan State University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Yoshifumi Itoh (University of Oxford, United Kingdom)
"Targeting MT1-MMP to the Invasion Front: Essential Process for Cellular Invasion and Tissue Destruction"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Robert Medcalf (Monash University, Australia)
"Plasminogen and the Immune Response During Injury"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Hunter Moore (University of Colorado Denver, USA)
"Plasminogen Activation in Trauma"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
James Whisstock (Monash University, Australia)
"New Insights Into the Control of Plasminogen Activation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure