Serine proteases of the plasminogen activation system and other extracellular proteases such as matrix metalloproteinases are critical mediators of numerous physiological and pathophysiological processes. Proper functioning of these systems is critical for development, tissue homeostasis, and host defense. In contrast, aberrant activity of these proteolytic systems is intimately associated with the genesis or progression of some of the most important human diseases, including cardiovascular disease, nervous system disorders, and cancer. Functioning at the interface cell-cell, cell-fluid and cell-matrix contact, extracellular proteases regulate cell proliferation, migration, invasion and signaling as well as matrix and tissue remodeling and repair. Indeed, given the diversity of function, better defining the intricate spatial and temporal regulatory mechanisms by which extracellular proteases function has remained an ongoing basic science and clinical priority for developing therapeutic intervention strategies aimed at improving human health.

This GRC will bring together leading researchers from across the globe to share the latest findings and advances on plasminogen activation and extracellular proteolysis. A defining principal for the conference will be to bridge the knowledge of the past with the resources and technologies of the future. As such, students and postdoctoral fellows will be paired with senior investigators in all facets of the conference, including as speakers and co-discussion leaders of all sessions. Topics will include cardiovascular and vascular biology, infection and immunity, neurological function and disease, metabolism and obesity, musculoskeletal disease, cancer biology, emerging technologies and therapies, and more. In addition to invited talks, ten talks will be selected from the submitted abstracts and incorporated into the sessions. Daily poster Sessions will feature prizes for best presentations by students and postdoctoral fellows.