Conference Description
Serine proteases of the plasminogen activation system and other extracellular proteases such as matrix metalloproteinases are critical mediators of numerous physiological and pathophysiological processes. Proper functioning of these systems is critical for development, tissue homeostasis, and host defense. In contrast, aberrant activity of these proteolytic systems is intimately associated with the genesis or progression of some of the most important human diseases, including cardiovascular disease, nervous system disorders, and cancer. Functioning at the interface cell-cell, cell-fluid and cell-matrix contact, extracellular proteases regulate cell proliferation, migration, invasion and signaling as well as matrix and tissue remodeling and repair. Indeed, given the diversity of function, better defining the intricate spatial and temporal regulatory mechanisms by which extracellular proteases function has remained an ongoing basic science and clinical priority for developing therapeutic intervention strategies aimed at improving human health.
This GRC will bring together leading researchers from across the globe to share the latest findings and advances on plasminogen activation and extracellular proteolysis. A defining principal for the conference will be to bridge the knowledge of the past with the resources and technologies of the future. As such, students and postdoctoral fellows will be paired with senior investigators in all facets of the conference, including as speakers and co-discussion leaders of all sessions. Topics will include cardiovascular and vascular biology, infection and immunity, neurological function and disease, metabolism and obesity, musculoskeletal disease, cancer biology, emerging technologies and therapies, and more. In addition to invited talks, ten talks will be selected from the submitted abstracts and incorporated into the sessions. Daily poster Sessions will feature prizes for best presentations by students and postdoctoral fellows.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by October 6, 2021. Please check back for updates.
Keynote Session: Bridging Mechanisms of Extracellular Proteolysis with Novel Therapeutic Strategies for Disease
Discussion Leaders
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Thomas Bugge (National Institute of Dental and Craniofacial Research, NIH, USA)
Speakers
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Edward Plow (Lerner Research Institute, Cleveland Clinic, USA)
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Nicola Mutch (University of Aberdeen, United Kingdom)
Proteases in Cardiovascular Disease and Thrombotic Disorders
Discussion Leaders
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Patricia Liaw (McMaster University, Canada)
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James Luyendyk (Michigan State University, USA)
Speakers
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Zsuzsa Bagoly (University of Debrecen, Hungary)
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Katherine Hajjar (Weill Cornell Medicine, USA)
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Luisa Iruela-Arispe (Feinberg School of Medicine, Northwestern University, USA)
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Paul Kim (Thrombosis and Atherosclerosis Research Institute (TaARI), Canada)
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Yuko Suzuki (Hamamatsu University School of Medicine, Japan)
Proteases in Infection and Immunity
Discussion Leaders
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Shaun Lee (University of Notre Dame, USA)
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Lindsey Miles (Scripps Research Institute, USA)
Speakers
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Silvio Antoniak (The University of North Carolina at Chapel Hill, USA)
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Rod Dunbar (The University of Auckland, Australia)
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Ana Flores-Mireles (University of Notre Dame, USA)
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Grant Blouse (Catalyst Biosciences, USA)
Proteases in Metabolic Disease and Aging
Discussion Leaders
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Lakmali Silva (National Institute of Dental and Craniofacial Research, NIH, USA)
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Dudley Strickland (University of Maryland School of Medicine, USA)
Speakers
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Lauren Hardy (Michigan State University, USA)
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Delphine Meynard (INSERM, France)
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Erica Sparkenbaugh (UNC Chapel Hill, USA)
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Douglas Vaughan (Northwestern University, USA)
Proteases in Cancer and Cell Signaling
Discussion Leaders
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Michael Ploug (Rigshospitalet, Denmark)
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Irit Sagi (Weizmann Institute of Science, Israel)
Speakers
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Toni Antalis (University of Maryland School of Medicine, USA)
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Benjamin Buckley (University of Wollongong, Australia)
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Karin List (Wayne State University School of Medicine, USA)
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Virginia Metrangolo (Finsen Laboratory/BRIC, Denmark)
New Technologies and Therapeutic Advances in Extracellular Proteolysis
Discussion Leaders
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Steven Gonias (University of California San Diego, USA)
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Ze Zheng (Medical College of Wisconsin, USA)
Speakers
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Albert Heck (Universiteit Utrecht, The Netherlands)
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Christian Kastrup (University of British Columbia, Canada)
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James Whisstock (Monash University, Australia)
Proteases in Tissue Remodeling and Regeneration
Discussion Leaders
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Francis Castellino (University of Notre Dame, USA)
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Marie Ranson (University of Wollongong, Australia)
Speakers
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Ulrich auf dem Keller (Technical University of Denmark, Denmark)
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Wendy Campana (VA San Diego Healthcare System, USA)
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Andrey Komissarov (University of Texas Health Center At Tyler, USA)
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Phillip Owens (University of Cincinnati, USA)
Proteases in Neurological and Cerebrovascular Disease
Discussion Leaders
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Jonathan Schoenecker (Vanderbilt University Medical Center, USA)
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Stella Tsirka (Stony Brook University, USA)
Speakers
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Eric Mullins (Cincinnati Children's Research Foundation, USA)
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Ekaterina Semina (Moscow State University, Russia)
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Manuel Yepes (Emory University, USA)
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Erin Norris (Rockefeller University, USA)
Proteases in Trauma
Discussion Leaders
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Daniel Lawrence (University of Michigan, USA)
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Sidney Strickland (The Rockefeller University, USA)
Speakers
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Matthew DuVernay (Vanderbilt UNiversity, USA)
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Yoshifumi Itoh (University of Oxford, United Kingdom)
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Robert Medcalf (Monash University, Australia)
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Hunter Moore (University of Colorado Denver, USA)
The GRC Power Hour™
Organizers:
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Ruby Law (Monash University, Australia)
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Li Zhang (University of Maryland School of Medicine, USA)
