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Polyamines

Gordon Research Conference

Polyamines in Cancer Biology, Inflammation, Microbiome, Plants and Pathogens

June 23 - 28, 2019

Chairs

and

Vice Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

This 2019 GRC/GRS conference will focus on the role of polyamines and polyamine metabolism in human diseases, especially inflammation and cancers. This will include work related to diseases involving multiple organ systems, including colon, stomach, pancreas, nervous system, various infections, the microbiome, biofilms, and plants. Speakers have been chosen to highlight the most recent discoveries related to the biological roles of polyamines and the important clinical trials investigating polyamine targeting therapies for cancer treatment and prevention.

Related Meeting

This GRC will be held in conjunction with the "Polyamines" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Recent Molecular Discoveries Discussion Leader:
7:40 pm - 7:45 pm	Opening Remarks
7:45 pm - 8:10 pm	"Polyamines and Non-Coding RNAs in Gastrointestinal Epithelial Homeostasis"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Hypusination in Macrophage Function, Diabetes and Metabolic Inflammatory Disease"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"In Vivo Consequences of Polyamine Imbalance: Insights from a Drosophila Model of Snyder-Robinson Syndrome"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Advances in Cancer Prevention and Treatment Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	"Neuroblastoma Trials and DFMO"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Colorectal Cancer Biomarkers and Prevention with DFMO"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Group Photo / Coffee Break
10:55 am - 11:25 am	"Targeting Polyamines in Pancreatic Cancer"
11:25 am - 11:35 am	Discussion
11:35 am - 12:05 pm	"Gastric Cancer Prevention: Polyamines as Targets and Novel Effects of DFMO"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Leveraging Polyamine Metabolic Stress to Enhance Sensitivity to Epigenetic Therapy for Prostate Cancer"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Advances in Inflammation and Cancer Biology Discussion Leader:
7:30 pm - 8:00 pm	"Oncogenic Signals Upstream and Downstream of Polyamine Biosynthesis in Prostate Cancer"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Tumor Immunology and Polyamines"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"New Drug Strategies Targeting Polyamines in Cancer Biology"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Arginine Metabolism: Upstream Factors in Disease Models Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	"Arginine Metabolism in Leishmania, Gene Expression Regulation and the Fate of the Infection"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Arginase 2 Suppresses Renal Carcinoma via Increased Polyamine Toxicity"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:25 am	"Arginine Utilization by Macrophages in the Control of Intracellular Pathogens"
11:25 am - 11:35 am	Discussion
11:35 am - 12:05 pm	"Arginine and Its Metabolism in Inflammatory Bowel Disease"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Early-Career Investigator Presentations / Late-Breaking Topics Discussion Leader:
7:30 pm - 7:40 pm	"Genetic Variability in ODC1 Intron 1 Hosted SNORA80B, a Small Nucleolar (sno)RNA, and Its Potential Consequences on rRNA Processing"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Polyamine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Polyamine Synthesis in Response to Efferocytosis Regulates Anti-Inflammatory Reprogramming of Macrophages"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"Functions of Polyamines Produced by the Intestinal Microbiome in Healthy Mice and Humans"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Metabolism of Apoptotic Cell-Derived Arginine and Ornithine into Putrescine by Macrophages Promotes Continual Efferocytosis"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Role of Polyamines in Anticancer Drug Resistance"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Polyamines in Aging and Other Diseases Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	"Polyamines, Synaptic Plasticity, Autophagy and Aging"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Dietary Spermidine Against Age-Associated Decline"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:25 am	"Polyamines as Protective Disease Modifiers in Congenital Muscular Dystrophy"
11:25 am - 11:35 am	Discussion
11:35 am - 12:05 pm	"SMOX Overexpression: Differential Effects in Skeletal Muscle and Nervous System"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Macrophage Reverse Transsulfuration Pathway Mediates Helicobacter pylori Immunopathogenesis by Regulating Polyamine Synthesis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Control of Polyamine Levels and Signaling Discussion Leader:
7:30 pm - 8:00 pm	"STREAP (STop-REad-Pause) Mechanism in the Translation of mRNA Encoding a Key Polyamine Pathway Enzyme AdoMetDC"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"EIF5A Is a Sensor and Effector for Polyamine Regulation of Antizyme, Antizyme Inhibitor, AdoMetDC and Polyamine Transporter Synthesis"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Physiological Functions of Polyamines and Their Metabolite, Acrolein"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	New Roles of Polyamines: Biofilms, Microbiome, Plants and Viruses Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	"Effects of Polyamines on Vibrio cholerae Biofilms"
9:35 am - 9:45 am	Discussion
9:45 am - 10:15 am	"The Genetic Analyses of Polyamine Transport and Biosynthesis in the Dominant Human Gut Microbes"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:25 am	"Ebolavirus Is Addicted to Polyamines and Hypusinated eIF5A"
11:25 am - 11:35 am	Discussion
11:35 am - 12:05 pm	"S-Adenosylmethionine Decarboxylase in Arabidopsis"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"ODC1: A Rare Patient, a Chance Meeting, a New Genetic Syndrome"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Keynote Session: Polyamines and Cancer Biology Session in memory of Seymour Cohen. Discussion Leaders: and
5:30 pm - 5:40 pm	"Investigating the Biology of DHPS Deficiency, a New Monogenic Disease"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Regulation of Ornithine Decarboxylase (ODC) Induction by UVB Is Dependent on mTORC1 in Human Keratinocytes"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"Understanding the Polyamine Stress Response in Tauopathies"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:20 pm	Introduction by Discussion Leader
6:20 pm - 7:00 pm	"Polyamines in Cancer Biology: Past, Present and Future"
7:00 pm - 7:20 pm	Discussion
7:20 pm - 7:30 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Jian-Ying Wang

Otto and Nicole Phanstiel

Patrick M. Woster

John and Marika Cleveland

Bob Casero

Leah Vardy

Keith Wilson

Susan and Neil Gilmour

Funding for this conference was made possible (in part) by 1R13CA239582-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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