Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Late-Breaking Discoveries in Polyamine Research
Discussion Leader: John Cleveland (Moffitt Cancer Center, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Daniel Puleston (Icahn School of Medicine at Mount Sinai, United States)
"Instruction of Immunity by Polyamines"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Late-Breaking Topic
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Late-Breaking Topic
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational Regulation by Polyamines
Discussion Leader: Thomas Dever (National Institutes of Health, United States)
9:00 am - 9:30 am
Katja Simon (University of Oxford, United Kingdom)
"Rejuvenating the Immune Response via Translational Regulation of Autophagy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Teresa Mastracci (Indiana University-Purdue University Indianapolis, United States)
"Hypusine Biosynthesis: Lessons Learned from Development and Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Sebastian Hofer (University of Graz, Austria, Austria)
"Spermidine-mediated Hypusination During Nutrient Deprivation: From Yeast to Humans."
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Duojia Pan (UT Southwestern Medical Center and HHMI)
"YAP/TAZ Drives Cell Proliferation and Tumor Growth via a Polyamine-eIF5A Hypusination-LSD1 Axis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Sonia Coni (Department of Molecular Medicine, Sapienza, University of Rome, Italy)
"Polyamines and eIF5A in Colorectal Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Heather Wallace (University of Aberdeen, United Kingdom), Leah Vardy (Skin Research Institute of Singapore, Singapore) and Manuela Cervelli (Roma Tre University, Italy)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines and Metabolism
Discussion Leader: Dominic Smiraglia (Roswell Park Comprehensive Cancer Center, United States)
7:30 pm - 8:00 pm
Tracy Murray Stewart (Johns Hopkins University, United States)
"Therapeutic Strategies Targeting Polyamine Metabolism in the Tumor Microenvironment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Frederic Bost (INSERM U1065, France)
"Hypusination and Cancer Cell Metabolism"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Leah Vardy (Skin Research Institute of Singapore, Singapore)
"Polyamine Catabolism is a Key Driver of Epidermal Wound Healing"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inborn Metabolic Diseases and Polyamines in Medical Genetics
Discussion Leader: Charles Schwartz (Michigan State University, United States)
9:00 am - 9:30 am
Caleb Bupp (Corewell Health/Helen DeVos Children's Hospital, United States)
"Bachmann-Bupp Syndrome: The First Treatable Polyamine Disorder"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Alban Ziegler (Columbia University Irving Medical Center, New York, NY, USA., United States)
"Hypusination Related Disorders: Genotypic and Phenotypic Spectrum"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Angela Peron (Università degli Studi di Firenze, Florence, Italy, Italy)
"Cardinal Signs of Snyder-Robinson Syndrome, a Congenital Polyamine Disorder"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Siddharth Banka (University of Manchester, United Kingdom)
"Germline Heterozygous EIF5A Variants Cause a Human Developmental Disorder"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines and Oxidative Stress in Degenerative Diseases
Discussion Leader: Manuela Cervelli (Roma Tre University, Italy)
7:30 pm - 8:00 pm
Peter Vangheluwe (KU Leuven)
"Impact of ATP13A2 on Polyamine Homeostasis in Cells and In Vivo"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Kenneth Lee (Penn State University, United States)
"Molecular Mechanism of Polyamine Transport by ATP13A2"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Laura Ciapponi (Sapienza, University of Rome, Italy)
"Translational Control of the ODC/Polyamine Axis by CNBP is Required for Muscle Function in Drosophila Melanogaster"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Clinical Prevention and Treatment of Cancer and Other Diseases
Discussion Leader: Heather Wallace (University of Aberdeen, United Kingdom)
9:00 am - 9:30 am
Kelly Goldsmith (Emory University School of Medicine, United States)
"ANBL1821: A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or without DFMO in Children with Relapsed, Refractory or Progressive Neuroblastoma, A Children’s Oncology Group Study"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Noymi Yam (Orbus Therapeutics, United States)
"Ongoing Clinical Evaluation of DFMO in Malignant Glioma and its Potential to Reduce Hypermutation Induced by Temozolomide Chemotherapy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Elizabeth Bruckheimer (Panbela Therapeutics, United States)
"Clinical Development of Polyamine Targeted Therapies"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Linda DiMeglio (Indiana University)
"Improving Beta Cell Survival and Health in Persons with Recent-Onset Type 1 Diabetes: Targeting Polyamines Using Difluoromethylornithine (DFMO)"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Medicinal Chemistry and Pharmacological Targeting of Polyamines
Discussion Leader: Takami Oka (Wakunaga, Japan)
7:30 pm - 8:00 pm
Patrick Woster (Medical University of South Carolina, United States)
"Recent Advances in the Discovery of Selective Spermine Oxidase Inhibitors"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Mark Burns (Aminex Therapeutics, Inc., United States)
"IND to Human Efficacy: Clinical Translation of AMXT 1501 Plus DFMO as Polyamine Transport and Biosynthesis Inhibitors for Cancer Therapy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Edmund Ellsworth (MICHIGAN STATE UNIVERSITY, United States)
"Rethinking the Design of Inhibitors of ODC"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Polyamines in Plants and Pathogens
Discussion Leader: Subhash Minocha (University of New Hampshire, United States)
9:00 am - 9:30 am
Keith Wilson (Vanderbilt University Medical Center, United States)
"Polyamines and Hypusination in Helicobacter Pylori Immunopathogenesis and Gastric Cancer Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Autar Mattoo (U.S. Department of Agriculture, United States)
"Comparative Genomics-Assisted Mapping of Polyamine (PA) Biosynthetic Pathway in Diverse Plant Systems"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Bryan Mounce (Loyola University Chicago Stritch School of Medicine, United States)
"Viral Manipulation and Use of Polyamines to Facilitate Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Annette Kaiser (University of Duisburg-Essen, Germany)
"Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in P. falciparum"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
Discussion Leader: Susan Gilmour (Lankenau Institute for Medical Research, United States)
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
Robert Casero (Johns Hopkins University School of Medicine, United States)
"The Enigma of Polyamine Function in Health and Disease"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure