Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Emerging Concepts in RNA Biology
Discussion Leader: Joan Steitz (Yale University , United States)
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7:40 pm - 8:00 pm |
Christine Mayr (Memorial Sloan Kettering Cancer Center, United States)
"Organization of Cellular Processes by Cytoplasmic Condensates"
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8:00 pm - 8:05 pm |
Discussion
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8:05 pm - 8:25 pm |
Mitch Guttman (California Institute of Technology, United States)
"How LncRNAs Shape Chromatin Structure to Control Gene Expression"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Benjamin Blencowe (University of Toronto, Canada)
"Role of Post-Transcriptional Regulation From Genotype to Phenotype"
|
8:50 pm - 8:55 pm |
Discussion
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8:55 pm - 9:15 pm |
Roy Parker (University of Colorado Boulder, United States)
"RNP Granules in Health and Disease"
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9:15 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
General Discussion
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Monday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Role of Post-Transcriptional Regulation From Genotype to Phenotype
Discussion Leader: Brenton Graveley (UConn Health, United States)
|
9:00 am - 9:20 am |
Auinash Kalsotra (University of Illinois at Urbana-Champaign, United States)
"The Good and Bad of RNA Splicing: Choose Your Alternative"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
William Fairbrother (Brown University, United States)
"Splicing Mutations and the Evolution of Exonic Splicing Enhancers"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Xinshu Xiao (University of California, Los Angeles, United States)
"Deciphering the Function of Single-Nucleotide Variants in the RNA"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Angela Brooks (University of California, Santa Cruz, United States)
"Investigating the Functional Role of Recurrent U2AF1 S34F Mutation in Lung Adenocarcinoma"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Alain Laederach (University of North Carolina at Chapel Hill, United States)
"In vivo RNA Structure at the Exon-Intron Junction Modulated by Rare Disease Variants, a Key Modulator of Splice Site Selection"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Juan Valcarcel (Centre for Genomic Regulation (CRG), Spain)
"Control of Pancreatic Islet Function and Glucose Homeostasis by a Novel Microexon Program Misregulated in Type 2 Diabetes"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Kristen Lynch (University of Pennsylvania, United States) and Karla Neugebauer (Yale University, United States)
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
3’ Processing
Discussion Leader: Chris Burge (MIT, United States)
|
7:30 pm - 7:50 pm |
Bin Tian (The Wistar Institute, United States)
"Alternative Polyadenylation, Mechanisms and Consequences"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Eric Wagner (University of Texas Medical Branch, United States)
"Alternative Polyadenylation: the Means to the End"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:40 pm |
Short Talk Selected from Poster Abstracts
|
8:40 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Short Talk Selected from Poster Abstracts
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Yongsheng Shi (University of California, Irvine, United States)
"Regulation of mRNA 3’ Processing in Development and Disease"
|
9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
RNA Decay
Discussion Leader: Karla Neugebauer (Yale University, United States)
|
9:00 am - 9:20 am |
Sujatha Jagannathan (University of Colorado Anschutz Medical Campus, United States)
"RNA decay; High-Throughput Examination of Rules Governing Nonsense-mediated RNA Decay"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Bobby Hogg (National Institutes of Health, United States)
"Gene Expression Regulation by NMD: Mechanisms of mRNA Protection and Deprotection"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Olivia Rissland (University of Colorado School of Medicine, United States)
"Connections Between Translation and mRNA Decay"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Group Photo / Coffee Break
|
11:00 am - 11:20 am |
Lynne Maquat (University of Rochester Medical Center, United States)
"Nonsense-Mediated mRNA Decay in Health and Disease"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Short Talk Selected from Poster Abstracts
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Heidi Cook-Andersen (University of California, San Diego, United States)
"Post-Transcriptional Mechanisms Driving the Transition from Oocyte to Embryo in Mammals"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
RNA Structure and Modifications
Discussion Leader: Wendy Gilbert (Yale University, United States)
|
7:30 pm - 7:50 pm |
Richard Gregory (Boston Children's Hospital / Harvard Medical School, United States)
"Role of RNA Methyltransferases in Gene Expression and Cancer"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Kathy Fange Liu (The University of Pennsylvania, United States)
"RNA Species Dance to the Beat of Modifications"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Steve Bonilla (University of Colorado, School of Medicine, United States)
"A Viral RNA Hijacks Cellular Machinery Using Conformational Changes of a Dynamic tRNA-Like Structure"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Blanton Tolbert (Case Western, United States)
"Mutual Allostery: An Underdeveloped Mechanism to Regulate Protein-RNA Biology"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Short Talk Selected from Poster Abstracts
|
9:25 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Regulation of Translation
Discussion Leader: Lynne Maquat (University of Rochester Medical Center, United States)
|
9:00 am - 9:20 am |
Katrin Karbstein (The Scripps Research Institute, United States)
"Ribosome Remodeling and Repair"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Jeff Coller (Case Western Reserve University, United States)
"Impact of Codon-tRNA Matching in Regulated Protein Expression"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Short Talk Selected from Poster Abstracts
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Davide Ruggero (University of California, San Francisco, United States)
"Post-Transcriptional Control in Cancer and its Therapeutic Implications"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Gloria Brar (University of California, Berkeley, United States)
"Long Undecoded Transcript Isoforms Underlie Dramatic Changes in Cellular State"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Joel Neilson (Baylor College of Medicine, United States)
"CELF-ish Control of Translation Initiation in Breast Cancer Progression"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 5:30 pm |
Poster Session
|
5:30 pm - 7:30 pm |
RNA Localization and Assembly
Discussion Leader: Douglas Black (University of California, Los Angeles, United States)
|
5:30 pm - 5:50 pm |
Beatriz Fontoura (University of Texas Southwestern Medical Center, United States)
"RNA Splicing and Trafficking Through Nuclear Speckles"
|
5:50 pm - 6:00 pm |
Discussion
|
6:00 pm - 6:20 pm |
Robin Stanley (National Institute of Environmental Health Sciences, NIH, United States)
"Regulation of Pre-rRNA Processing"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:40 pm |
Short Talk Selected from Poster Abstracts
|
6:40 pm - 6:45 pm |
Discussion
|
6:45 pm - 6:55 pm |
Short Talk Selected from Poster Abstracts
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Kimberly Mowry (Brown University, United States)
"RNA-Protein Interactions in RNA Transport Granules"
|
7:20 pm - 7:30 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
RNP Function and Disease Implications
Discussion Leader: Manuel Ares (University of California, Santa Cruz, United States)
|
9:00 am - 9:20 am |
Peter Sarnow (Stanford University, United States)
"Roles for RNA Virus-Derived Circular RNAs in Viral Pathogenesis"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Sara Cherry (University of Pennsylvania, United States)
"Defining the Interface Between RNA Viruses and Cellular RNA Binding Proteins"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:40 am |
Short Talk Selected from Poster Abstracts
|
10:40 am - 10:45 am |
Discussion
|
10:45 am - 10:55 am |
Esther Obeng (St. Jude Children's Research Hospital, United States)
"SF3B1 Mutations in Myeloid Malignancies"
|
10:55 am - 11:00 am |
Discussion
|
11:00 am - 11:20 am |
Kathryn Hamilton (University of Pennsylvania / Children's Hospital of Philadelphia, United States)
"Dynamic Regulation of Intestinal Tissue Repair via RNA Binding Protein IMP1/IGF2BP1"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Adrian Krainer (Cold Spring Harbor Laboratory, United States)
"Antisense-Mediated PKM Splice-Switching to Target Hepatocellular Carcinoma"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Rui Zhao (University of Colorado Anschutz Medical Campus, United States)
"Structure and Function of the Spliceosome"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Integration of RNA Biogenesis Steps
Discussion Leader: Nicholas Conrad (University of Texas Southwestern Medical Center, United States)
|
7:30 pm - 7:50 pm |
Matthew Simon (Yale University, United States)
"Revealing the Dynamic Regulation of Cellular RNAs Using Nucleotide Recoding Experiments"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Tracy Johnson (University of California, Los Angeles, United States)
"RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene Expression"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
David Bentley (University of Colorado School of Medicine, United States)
"Transcription Speed: Why it Matters and how to Control it"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Eric Wang (University of Florida, United States)
"Repeat Expansions Instigate Supply Chain Issues in the Nucleus and Cytoplasm"
|
9:20 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|