1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
RNA Binding Protein Regulation
Ezequiel Calvo-Roitberg (University of Massachusetts Medical School, United States)
3:45 pm - 3:55 pm
Sarah Harris (UNC Chapel Hill, United States) "Evolution of RNA Binding and Regulation"
3:55 pm - 4:00 pm
4:00 pm - 4:10 pm
Simon Currie (UT Southwestern Medical Center, United States) "Quantitative Reconstitution of Yeast RNA Processing Bodies"
4:10 pm - 4:15 pm
4:15 pm - 4:25 pm
Shruthi Rengarajan (Whitehead Institute, MIT Biology, United States) "The X-linked RNA Helicase DDX3X is Post-transcriptionally Regulated in Response to its Y-homolog, DDX3Y"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
RNA Processing and disease
Carolyn Sangokoya (University of California, San Francisco, United States) and Jacob Gordon (NIEHS/NIH (US) & University of Cambridge (UK), United States)
7:30 pm - 7:40 pm
Leslie Torres Ulloa (University of Massachusetts Chan Medical School, United States) "Estimating the Kinetics of mRNA 3’ End Cleavage"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Arnaud Liehrmann (Institut des Sciences des Plantes de Paris-Saclay, France) "DiffSegR: an RNA-Seq Data Driven Method for Differential Expression Analysis Using Changepoint Detection"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Susan Liao (New York University (Courant Institute of Mathematical Sciences), United States) "Interpretable Machine Learning to Decipher Post-Transcriptional Regulatory Logic"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Larissa Nitschke (Baylor College of Medicine, United States) "Alternative Splicing Mediates the Compensatory Upregulation of MBNL2 Upon MBNL1 Loss-of-Function"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
Timofey Karginov (UConn Health, United States) "T cell Activation Induces Splicing of Ultraconserved Poison Exon Elements in RNA Binding Proteins to Allow Expansion and Effector Function during Immune Response"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Brittany Angarola (The Jackson Laboratory, United States) "Defining Aging-associated RNA Splicing as an Oncogenic Factor in Breast"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Karli Lipinski (University of Wisconsin-Madison, United States) "Synthesis by RNA Polymerase III is not Required for U6 snRNA Function"
9:10 pm - 9:15 pm
9:15 pm - 9:25 pm
Irene Beusch (University of California, San Francisco, United States) "Functional Genomics of the Human Spliceosome in Haploid Cells Reveals in vivo Functions of SUGP1 and SF1"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
RNA Decay and Translation
Michael Lawson (Stanford University School of Medicine, United States)
9:00 am - 9:10 am
Lindsay Becker (Princeton University, United States) "Investigating the Role of P-Bodies in Translation Regulation in Neurons"
9:10 am - 9:15 am
9:15 am - 9:25 am
Jackson Gordon (Yale University, United States) "Phosphorylation-Dependent Inhibition of PABPN1 Maintains Poly(A) Tail Lengths During Mitosis"
9:25 am - 9:30 am
9:30 am - 9:40 am
Cassandra Hayne (NIEHS/NIH, United States) "Structure of the tRNA Splicing Endonuclease Complex Reveals Insight into tRNA Recognition and Processing"
9:40 am - 9:45 am
9:45 am - 9:55 am
Gabrielle Zuniga (UT Health San Antonio, United States) "Tau-induced Deficits in Nonsense-mediated mRNA Decay Contribute to Neurodegeneration"
9:55 am - 10:00 am
10:00 am - 10:10 am
Prerna Malaney (MD Anderson Cancer Center, United States) "Decoding Mechanisms of hnRNP K Dysfunction in Au Kline Syndrome"
10:10 am - 10:15 am
10:15 am - 10:25 am
Michael Cortázar Osorio (University of Colorado Anschutz Medical Campus, United States) "Saturation Genome Editing as a Tool to Identify Rules that Govern NMD Activity"
10:25 am - 10:30 am
10:30 am - 10:40 am
Sarah Fritz (NIH/NHLBI, United States) "An Alternative UPF1 Isoform Drives Conditional Remodeling of Nonsense-Mediated mRNA Decay"
10:40 am - 10:45 am
10:45 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Bridget Begg (University of Pennsylvania Perelman School of Medicine, United States)
1:30 pm - 2:20 pm
Tracy Johnson (University of California, Los Angeles, United States)
Stephen Floor (University of California, San Francisco, United States)
Maria Alexis (Remix Therapeutics, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)
4:00 pm - 4:10 pm