Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Gaps in Disease Treatment Impacting Large and Small Patient Populations
Discussion Leaders: Allen Templeton (Merck & Co. Inc., United States) and Rupinder Kaur (Charles River Laboratories , United States)
7:40 pm - 8:20 pm
Jennifer Dent (BIO Ventures for Global Health, United States)
"The Often Overlooked Issue of Cancer in a Global Health Setting"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Federico Mingozzi (Spark Therapeutics, United States)
"Challenges and Opportunities in In Vivo Gene Therapy for Rare Diseases"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Frontiers of Gene Based Therapies
Discussion Leaders: Gregg Duncan (University of Maryland, United States) and Srinivas Tummala (Bristol Myers Squibb, United States)
9:00 am - 9:30 am
Millicent Sullivan (University of Delaware, United States)
"Peptide-Based Collagen Modification for Gene Therapy During Wound Repair"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Jessica Rouge (University of Connecticut, United States)
"Overcoming Biological Barriers to Nucleic Acid Nanomaterial Delivery Using Enzymatically Releasable DNA-Surfactant Conjugates"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Lennart Lindfors (AstraZeneca R&D Gothenburg, Sweden)
"Big Molecules and Small Particles: LNP Structure-Activity from Physicochemical Characterization"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
David Schaffer (University of California, Berkeley, United States)
"Directed Evolution of Novel Aden-Associated Viral Vectors for Clinical Gene Therapy"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Christel Bergstrom (Uppsala University, Sweden) and Lauren Austin (Merck, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advanced Manufacturing to Deliver Therapies From One to Billions
Discussion Leaders: Brenda Carrillo-Conde (Pfizer Inc, United States) and Matt Defrese (Cyrus Scientific, United States)
7:30 pm - 8:00 pm
Theodore Randolph (University of Colorado Boulder, United States)
"Atomic Layer Deposition Techniques for Formulating Thermostable, Single-Shot Vaccines"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Alvaro Goyanes (FabRx Ltd - UCL, United Kingdom)
"3D Printing for Preclinical Development Medicines and Clinical Applications"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Maxine Prestipino (Merck & Co, United States)
"Flexible Manufacture; Innovations Reducing Time to Patient"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Characterization Techniques Applicable Across Small and Large Molecules
Discussion Leaders: Li Di (Pfizer, United States) and Marianna Yanez Arteta (AstraZeneca, Sweden)
9:00 am - 9:30 am
Boris Rybtchinski (Weizmann Institute of Science, Israel)
"Crystallization Mechanisms of Pharmaceuticals Elucidated by Electron Microscopy"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Mei Hong (Massachusetts Institute of Technology, United States)
"New 19F Solid-State NMR Methods for Biomolecular Structure Determination"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Nancy Allbritton (University of Washington, United States)
"Intestine-On-Chip As a Tool for Development of Therapeutic Strategies"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Karen Edler (Lund University, Sweden)
"X-Ray and Neutron Scattering from Emulsions, Nanoparticles and Lipid Constructs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
In Silico Methodologies Applied on Form and Formulation
Discussion Leader: Siladitya Ray Chaudhuri (Janssen)
7:30 pm - 8:00 pm
John Shelley (Schrodinger, Inc., United States)
"Modeling for Small Molecule Drug and Biologics Formulations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Gabriele Sadowski (TU Dortmund, Germany)
"Thermodynamic Modeling for Formulation Development"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Carlos Borca (PTC Therapeutics, Inc., United States)
"Leveraging Automation Technologies to Optimize Solutions Applicable in the Pharmaceutical Industry"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next Generation Formulation Strategies for New Modalities
Discussion Leaders: Susan Joyce (University College Cork, Ireland) and Shannon Sirk (University of Illinois Urbana-Champaign, United States)
9:00 am - 9:30 am
Wenzhan Yang (AstraZeneca Pharmaceuticals LP, United States)
"Formulation Approaches to Overcome Delivery Challenges of PROTACs in Drug Discovery"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
James Moon (University of Michigan, United States)
"Engineering Strategies for In Situ Modulation of the Gut Microbiome"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Kathryn Whitehead (Carnegie Mellon University, United States)
"Effects of Lipid Nanoparticle Chemistry on mRNA Efficacy and Immunogenicity"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Tal Danino (Columbia University, United States)
"Engineering Bacteria for Cancer Therapy"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Leaders in Preclinical Form and Formulation
Discussion Leader: Grace Okoh (Merck & Co., Inc., United States)
7:30 pm - 7:45 pm
Late-Breaking Topic
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Short Talk Selected from Poster Abstracts
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Late-Breaking Topic
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Late-Breaking Topic
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Solubility and Permeability Challenges for Oral Delivery of Large Molecules
Discussion Leaders: Freddy Arce (Bristol Myers Squibb, United States) and Geoff Zhang (AbbVie Inc., United States)
9:00 am - 9:30 am
Vincent Jannin (Lonza / Capsugel France SAS, France)
"Evaluation of the Acid-Protection and Enteric Delivery Performance of an Innovative Functional Capsule"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Christel Bergstrom (Uppsala University, Sweden)
"Virtual Assessment of Formulation Effects on Orally Delivered Poorly Solubles, Poorly Permeables: The BRO5 Chemical Space"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
David Brayden (University College Dublin, Ireland)
"Formulation Lessons for the Oral Administration of Peptides: Matching Enabling Technologies to Candidates"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Ramesh Gupta (3P Biotechnologies, United States)
"Milk/Colostrum Exosomes: A Nanoplatform for Delivery of Small Molecules and Genes"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drug Design and Delivery for Global Health Medicines
Discussion Leaders: Lia Bersin (Moderna Therapeutics, United States) and Ellen Minnihan (Gates Medical Research Institute, United States)
7:30 pm - 8:00 pm
Mathew Njoroge (University of Cape Town, South Africa)
"Preclinical Formulation and Pharmacokinetic Evaluation of Novel Compounds in a Malaria Drug Discovery Project"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Niya Bowers (BMGF, United States)
"Preclinical and Early Clinical Formulation for Global Health Drug Development: Needs and Challenges"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Mark Prausnitz (Georgia Institute of Technology, United States)
"Microneedle Patch Technology for Vaccination and Long-Acting Contraception"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure