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Carbohydrates
Gordon Research Conference

Chemical and Biochemical Approaches to Deciphering Glycan Functions

Dates

June 25-30, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chair:
Lai-Xi Wang

Vice Chairs:
Zhongwu Guo & Xi Chen

Meeting Description

Advances in carbohydrate chemistry and glycobiology have revealed diverse roles and functions of glycans in a number of important physiological and disease processes. Yet a vast chemical and functional space of glycans remains to be explored, and we have just begun to decode the glycomes of living species. The main goal of the Gordon Research Conference on Carbohydrates is to bring together an outstanding and diverse group of scientists who work at the frontiers of basic and translational glycoscience to discuss their recent work and to explore the next frontiers in the field. This meeting will emphasize the interplay of chemistry, biology, biotechnology and medicine with a focus on molecular approaches to deciphering glycan functions. The meeting provides a unique platform and a collegial environment to foster the interactions among graduate students, postdoctoral fellows, junior and established scientists to discuss the latest findings and to exchange ideas in this multidisciplinary field. The scientific sessions will cover diverse areas of the field, including fundamental research in synthetic and analytic carbohydrate chemistry, recent developments of enabling technologies for functional glycomics, the molecular understanding of protein-carbohydrate interactions, the development of carbohydrate-based therapeutic agents and glycoconjugate vaccines, and the exploration of specific glycan recognition for bio-medicine. The core of this Carbohydrates GRC will consist of about 27 invited talks and 20-25 short talks (selected from abstracts), along with highly interactive poster sessions. In addition, the inaugural Carbohydrate Gordon Research Seminar (GRS) will be held just prior to the Carbohydrates GRC. The Carbohydrate GRS will provide a collegial environment for a growing number of younger scientists (graduate students, postdocs, junior faculty members etc) in glycoscience to disseminate scientific information related to the field, establish scientific network, discuss potential collaborations, and gain confidence towards participation and contribution to the dialogue in the following GRC.

Related Meeting

This GRC was held in conjunction with the "Carbohydrates" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnabling Technologies for Functional Glycomics
Discussion Leader: Joseph Barchi (National Cancer Institute, NIH, USA)
7:40 pm - 8:05 pmRichard Cummings (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Human Glycomics and Deciphering the Expression and Biological Recognition of Glycans"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmNicola Pohl (Indiana University, USA)
"A Systems Approach to Carbohydrate Synthesis and Analysis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJeffrey Gildersleeve (National Cancer Institute, NIH, USA)
"Exploiting Anti-Glycan Immunity to Improve Cancer Care"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycosylation and Synthetic Methodology
Discussion Leaders: Valentin Wittmann (University of Konstanz, Germany) and Biao Yu (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
9:00 am - 9:25 amAlexei Demchenko (University of Missouri-St. Louis, USA)
"From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAntony Fairbanks (The University of Canterbury, New Zealand)
"Protecting Group Free Transformations of Reducing Sugars in Aqueous Solution"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Xin-Shan Ye (Peking University, China)
"Photo-Induced Glycosylation Reactions"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amYasuhiro Kajihara (Osaka University, Japan)
"Synthesis of Glycoconjugates for Elucidation of Oligosaccharide Functions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Jin-Song Yang (Sichuan University, China)
"Stereoselective Synthesis of Kdo Glycoside"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Clay Bennett (Tufts University, USA)
"Chemical Promoters for Controlling Selectivity in Glycosylation Reactions"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Cheng-Chung Wang (Institute of Chemistry, Academia Sinica, Taiwan)
"Chemistry on Protection and Functionalization of Free Sugars"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Alyssa Pirinelli (University of Minnesota Morris, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Glycobiology
Discussion Leader: Xi Chen (University of California, Davis, USA)
7:30 pm - 7:55 pmLinda Hsieh-Wilson (California Institute of Technology, USA)
"Carbohydrate Recognition and Signaling in the Brain"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmJames Paulson (The Scripps Research Institute, USA)
"Human Influenza Virus Receptors"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJennifer Kohler (University of Texas Southwestern Medical Center, USA)
"Discovery of Host Cell Glycans Recognized by Bacterial Toxins"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Kamil Godula (University of California, San Diego, USA)
"Chemical Editing of the Glycocalyx to Influence Stem Cell Differentiation"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEnzymatic and Chemoenzymatic Assembly of Glycans
Discussion Leader: Peng George Wang (Georgia State University, USA)
9:00 am - 9:25 amHung-Wen Liu (University of Texas at Austin, USA)
"Biosynthetic Studies of Oxetanocin A"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amVladimir Kren (Czech Academy of Sciences, Czech Republic)
"Mutant Glycosyltransferases and Hexosaminidases in the Synthesis of Advanced Glycomaterials"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Juergen Seibel (University of Wuerzburg, Germany)
"Switching Enzyme Specificity from Phosphate to Resveratrol Glucosylation via Domain-Shift"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amStephen Withers (University of British Columbia, Canada)
"Discovering New Glycosidases Through Metagenomics and Gene Synthesis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Hongzhi Cao (Shandong University, China)
"Enzymatic Modular Assembly of Human Blood Antigens"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Ethan Goddard-Borger (Walter and Eliza Hall Institute, Australia)
"New Insights into the Process and Function of Tryptophan C-Mannosylation Provided by Yeast Engineered to Perform This Protein Modification"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Mads Clausen (Technical University of Denmark, Denmark)
"Synthesis and Application of Oligosaccharides Related to Plant Cell Wall Glycans"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Recognition in Protein-Carbohydrate Interactions
Discussion Leaders: Xing Chen (Peking University, China) and Lara Mahal (New York University, USA)
7:30 pm - 7:55 pmAnne Imberty (CERMAV, CNRS, France)
"Microbial Lectins Binding to Lewis Glycotopes: Experimental and Computational Study"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRobert Sackstein (Harvard Medical School, USA)
"Glycosyltransferases as Tools to Identify Cell Surface Lactosaminyl Glycans"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPeng Wu (Scripps Research Institute, USA)
"Chemoenzymatic Detection of Glycans: Methods and Applications"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Zhongping Tan (University of Colorado Boulder, USA)
"Using Chemical Biology to Understand and Apply Protein O-Glycosylation"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCarbohydrate Vaccines and Glyco-Immunology
Discussion Leaders: Xuefei Huang (Michigan State University, USA) and Steven Sucheck (The University of Toledo, USA)
9:00 am - 9:25 amPeter Seeberger (Max-Planck-Institute of Colloids and Interfaces, Germany)
"From Biologicals to Pharmaceuticals: A Medicinal Chemistry Approach to Carbohydrate-Conjugate Vaccines Against Streptococcus pneumoniae and Other Bacteria"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amYan-Mei Li (Tsinghua University, China)
"Glycopeptide Vaccines for Cancer Immunotherapy"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Wei Huang (Chinese Academy of Sciences, China)
"Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amPeter Andreana (University of Toledo, USA)
"An Entirely Carbohydrate-Recognizing Monoclonal Antibody"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Jillian Prendergast (Siamab Therapeutics, Inc., USA)
"Anti-Sialyl-Tn Monoclonal Antibody-Drug Conjugates (ADCs) Demonstrate Tumor Specificity In Vitro and In Vivo Antitumor Efficacy"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Dapeng Zhou (Tongji University, China)
"Precision Mapping of MUC1 Glycopeptides Expressed by Non-Small Cell Carcinoma"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Steven Townsend (Vanderbilt University, USA)
"Carbohydrate Involvement in Group B Streptococcus (GBS) Pathogenesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructural Chemistry and Biology of Carbohydrates
Discussion Leader: Zhongwu Guo (University of Florida, USA)
7:30 pm - 7:55 pmRobert Woods (University of Georgia, USA)
"Computational and Biophysical Insight into Glycan Specificity: The Role of Entropy and Avidity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmYuriy Knirel (N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia)
"Capsular Polysaccharides of the Nosocomial Pathogen Acinetobacter baumannii: Structure, Genetics, and Cleavage by Bacteriophages"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmCatherine Costello (Boston University School of Medicine, USA)
"Can Advances in Mass Spectrometry Unlock the Mysteries of Glycans?"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Jiaoyang Jiang (University of Wisconsin-Madison, USA)
"Structures of Human O-GlcNAcase and Its Complexes Reveal a New Substrate Recognition Mode"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmSynthetic Probes for Deciphering Carbohydrate Functions
Discussion Leader: George O'Doherty (Northeastern University, USA)
9:00 am - 9:25 amYukishige Ito (RIKEN, Japan)
"Synthetic Substrates for the Analysis of Glycan Processing Enzymes in the ER"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTodd Lowary (University of Alberta, Canada)
"Synthesis of Designer Polysaccharides"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Suvarn Kulkarni (Indian Institute of Technology Bombay, India)
"Synthesis of Rare Sugar AAT Containing Bacterial Glycoconjugates"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amEriks Rozners (Binghamton University, USA)
"Carbohydrate Chemistry for RNA Interference: Synthesis, Structure and Biological Activity of Amide-Linked RNA"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amShang-Cheng Hung (Academia Sinica, Taiwan)
"Synthesis and Characterization of Specific Heparan Sulfate-Protein Interactions"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: M. Carmen Galan (University of Bristol, United Kingdom)
"Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycans in Biotechnology and Medicine
Discussion Leader: Philip Deshong (University of Maryland, College Park, USA)
7:30 pm - 7:55 pmJian Liu (University of North Carolina at Chapel Hill, USA)
"Developing an Enzyme-Based Approach to Synthetize Glycosaminoglycans"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmShin-Ichiro Nishimura (Hokkaido University, Japan)
"Nanomedicine Targeting Intracellular Glycoenzymes"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmSelected from Poster Abstracts: Dennis Whitfield (Sussex Research Laboratories Inc, Canada)
"Glycosylation of a Subfragment Peptide of Type I Collagen"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJohn Magnani (GlycoMimetics, Inc., USA)
"Three Different Glycomimetic Drugs in Clinical Trials for Inflammatory Disorders and Cancer"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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