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Cell Contact & Adhesion
Gordon Research Conference

Collective Behaviors and Mechanics in Health and Disease

Dates

June 28 - July 3, 2015

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Cara J. Gottardi

Vice Chair:
Andrea McClatchey

Meeting Description

Intercellular adhesions are traditionally regarded as multi-protein complexes that form structural rivets or "junctions" between cells, effectively tethering the cytoskeletons of neighboring cells through these structures. Recently, it has become apparent that proteins that comprise these junctions are structurally altered under mechanical tension, resulting in different protein binding characteristics that lead to changes in the macromolecular structure of adhesions. Emerging evidence that a cell’s stiffness promotes tissue proliferation and may serve as a "biomarker" for metastatic potential and organ fibrosis indicates that a deeper understanding of the mechanical properties of cells within tissues will be an important new frontier. Therefore, the goal of this conference will be to focus the presentations and general discussions on how intercellular junctions respond to changes in tension and how such changes are conveyed to a cell’s interior to coordinate collective cell behaviors relevant to development (e.g., cell-on-cell migrations or intercellular intercalations required for tissue elongation) and disease (e.g., tumor invasion-front migrations). Participants from diverse backgrounds who do not frequently interact in other venues--ranging from biophysicists and biochemists to cell and developmental biologists--are invited to this meeting to achieve a more integrated "angstroms to tissue" view of cell contact and adhesion relevant to heath and disease. Several short talks will also be selected from the abstracts.

Related Meeting

This GRC was held in conjunction with the "Cell Contact & Adhesion" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: State of the Field: Integrating Cell Contact and Adhesion with Tissue Organization
Discussion Leader: Cara Gottardi (Northwestern Feinberg School of Medicine, USA)
7:40 pm - 8:10 pmMarino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Multi-Scale Analysis of Liver Tissue Organisation"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmJennifer Zallen (Sloan-Kettering Institute, USA)
"Shaping the Embryo: Signals and Forces in Development"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmChristopher Chen (Boston University, USA)
"Adhesion, Forces, Form and Multicellular Multidimensional Tango"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdhesion in Cell and Tissue Polarization
Discussion Leader: Andrea McClatchey (Harvard Medical School, USA)
9:00 am - 9:20 amAdam Martin (Massachusetts Institute of Technology, USA)
"Functional Genomics Reveals Cytoskeletal Dynamics Begets Stable Force Transmission"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJeff Hardin (University of Wisconsin, USA)
"From Angstroms to Embryos: Regulating Cadherin-Based Adhesion in C. elegans"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amDenise Montell (University of California, Santa Barbara, USA)
"Mechanics of Collective Cell Migrations in Drosophila"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSergei Sokol (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Apical Constriction During Neural Tube Closure by Wnt/PCP and Mechanical Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amDaniel Fletcher (University of California, Berkeley, USA)
"Protein Segregation at Membrane Interfaces"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAndrew Gladden (MD Anderson Cancer Center, USA)
"Regulation of Lumen Formation and Cell Adhesion by the Tyrosine Phosphatase, PTPN14"
12:10 pm - 12:20 pmRuth Johnson (Wesleyan University, USA)
"The Adaptor Protein Cindr (Cd2ap) Fine-Tunes JNK to Maintain Tissue Integrity and Regulate Morphogenesis"
12:20 pm - 12:30 pmChen Luxenburg (Tel Aviv University, Israel)
"Key Roles for WDR1 in Epidermal Planar Polarity"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmActin Regulation and Organization at Cell Contacts
Discussion Leader: Adam Kwiatkowski (University of Pittsburgh School of Medicine, USA)
7:30 pm - 7:50 pmWilliam Brieher (University of Illinois, USA)
"The Biochemistry of Actin Assembly at Cell Junctions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMargaret Gardel (The University of Chicago, USA)
"Regulation of Branching Morphogenesis by Dia1"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmUlrich Tepass (University of Toronto, Canada)
"α-Catenin in Flies"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmNicolas Plachta (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Controlling Cell Fate, Shape and Position in the Early Mouse Embryo"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAdhesion Regulation and Collective Cell Behaviors
Discussion Leader: Andrew Kowalczyk (Emory University, USA)
9:00 am - 9:20 amFrancois Fagotto (McGill University, Canada)
"Local vs. Global Regulation of Adhesion and Cortical Contractility in Cell Sorting and Tissue Separation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndrew Loza (Washington University at St. Louis School of Medicine, USA)
"Bioengineering Paradigms for Cell Migration"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amRene Mege (University of Paris-Diderot, CNRS, France)
"The α-Catenin/Vinculin Mechanosensor and Collective Cell Migration"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMasatoshi Takeichi (RIKEN Center for Developmental Biology, Japan)
"Catenin-Dependent Regulation of Cell Migration"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJeffrey Fredberg (Harvard University, USA)
"Unjamming and Cell Shape in the Asthmatic Airway Epithelium"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmTamal Das (Max Planck Institute for Intelligent Systems, Germany)
"A Mechanotransduction Pathway Regulates Collective Migration of Epithelial Cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenerating and Bearing Force at Cell-Cell Junctions
Discussion Leader: Stephan Huveneers (Sanquin Research, The Netherlands)
7:30 pm - 7:50 pmKathleen Green (Northwestern University, USA)
"Desmosomes' Functional Diversity in Differentiation and Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAlexander Dunn (Stanford University, USA)
"The Minimal Cadherin-Catenin Complex Forms a Force-Sensitive Link to Actin at Cell-Cell Contacts"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmDeborah Leckband (University of Illinois, USA)
"Tension-Sensing at Cadherin Contacts"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmAsako Shindo (Nagoya University, Japan)
"Septins Control Contractile Force During Epithelial Wound Closure"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRonen Zaidel-Bar (National University of Singapore, Singapore)
"Non-Junctional E-Cadherin Clusters Regulate Cortical Contractility and Modulate Cytokinesis in the C. elegans Embryo"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarrier and Signaling Functions of Tight and Other Junctions
Discussion Leader: Vivian Tang (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:20 amJames Anderson (National Institutes of Health, USA)
"Dynamic Remodeling at the Tight Junction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJerrold Turner (The University of Chicago, USA)
"Plasticity of Mucosal Barriers"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amCarien Niessen (University of Cologne, Germany)
"Polarization of Stratifying Epithelia in Cell Fate Regulation and Barrier Function"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSandra Citi (University of Geneva, Switzerland)
"Signalling by Epithelial Zonular Junctions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKris DeMali (University of Iowa Carver College of Medicine, USA)
"Molecular Mechanisms of Cadherin-Mediated Mechanotransduction"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSpiro Getsios (Northwestern University, USA)
"Receptor Tyrosine Signaling Networks at Epithelial Cell-Cell Contacts Governing Differentiation State"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTomohito Higashi (University of Michigan, USA)
"Remodeling of Cell-Cell Junctions and Formation of Nascent Tricellular Junctions During Cytokinesis in Vertebrate Epithelial Tissues"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCell Contact Regulation in Disease
Discussion Leader: Rachel Hazan (Albert Einstein College of Medicine, USA)
7:30 pm - 7:50 pmAndrew Ewald (Johns Hopkins University School of Medicine, USA)
"How Do Cells Migrate Through and Escape from Epithelial Tissues?"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAlbert Reynolds (Vanderbilt University, USA)
"The p120-Catenin Family in Epithelial Structure and Cancer"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPatrick Derksen (University Medical Center Utrecht, The Netherlands)
"Loss of Adherens Junctions and the Regulation of Tumor Progression"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGreg Longmore (Washington University at St. Louis School of Medicine, USA)
"Epithelial Morphogenesis in Cancer Metastasis"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Adhesion Signaling Mechanisms
Discussion Leader: Vania Braga (Imperial College London, United Kingdom)
9:00 am - 9:10 amKari Barlan (University of Chicago, USA)
"The Fat2 Cadherin Regulates Collective Cell Migration via a Novel Planar Signaling Mechanism in the Drosophila Egg Chamber"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amJakub Sedzinski (University of Texas, USA)
"Forces Driving Emergence of an Apical Epithelial Cell Surface In Vivo"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amMartin Schwartz (Yale School of Medicine, USA)
"Mechanotransduction by Cell-Cell Adhesion Receptors in Endothelial Cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amVoula Mili (National Cancer Institute, NIH, USA)
"Regulation and Functions of RNAs Localized at Cellular Protrusions"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amValeri Vasioukhin (Fred Hutchinson Cancer Research Center, USA)
"Junction Proteins in Signaling, Polarity and Cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPanos Anastasiadis (Mayo Clinic, USA)
"Unexpected Crosstalk Between Adherens Junctions and the RNAi Machinery"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJuliet Daniel (McMaster University, Canada)
"Dancing from Top to Bottom: Kaiso Adhesion Roles in Breast and Colon Cancer"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmXiaoyang Wu (University of Chicago, USA)
"A Phosphorylation Switch Regulates ACF7 Function in Cytoskeletal Crosslinking and Focal Adhesion Dynamics"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdhesion Mechanisms During Tissue Morphogenesis
Discussion Leader: Pierre McCrea (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:50 pmHelen McNeill (Lunenfeld Tanenbaum Research Institute, Canada)
"Coordinating Growth and Tissue Organization with the Hippo Pathway"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMark Peifer (University of North Carolina at Chapel Hill, USA)
"Building the Body Plan: The Miracle of Morphogenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMo Weng (Princeton University, USA)
"Tension-Dependent Remodeling of Adherens Junctions Protects Junctions from Snail-Dependent Disassembly"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmGloria Slattum (University of Utah, USA)
"Oncogenic K-Ras Expression and Basal Extrusion Promotes Cell Invasion in the Developing Zebrafish Epidermis"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAlpha Yap (The University of Queensland, Australia)
"Active Junctional Tension and Tissue Morphogenesis"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA195999. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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