Gordon Research Conferences
Meeting Details
Search:
  GO

Cell Contact & Adhesion
Gordon Research Conference

Cell Contact as a Master Regulator of Membrane Organization, Mechanics and Signaling

Dates

June 18-23, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chair:
Andrea McClatchey

Vice Chair:
Andrew J. Ewald

Application Deadline

Applications for this meeting must be submitted by May 21, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Research Conference (GRC) on Cell Contact & Adhesion (CC&A) and associated Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows will be held from June 17-23 at Proctor Academy, Andover, NH. The GRC has been held biannually since 1973 and has led both scientific progress and the training/mentoring pipeline of young scientists in the field. In work often presented in unpublished form at the CC&A GRC, the CC&A community has driven an appreciation of the complex and dynamic nature of cell contacts and their central role in guiding many cell behaviors such as polarity, signaling and mechanics and in driving human disease, particularly cancer. The scientific and social themes of the 2017 meeting seek to build unity in both the science of cell contacts and within the CC&A community. This will be achieved by communicating unpublished data, nucleating innovative multidisciplinary collaborations, defining community standards that enhance the rigor and reproducibility of cell adhesion experiments and mapping strategies for community-driven support for trainees/future scientific leaders.

Cell-cell contacts were initiating elements in the evolution of multicellular life forms. The 2017 CC&A GRC scientific program reflects the central role of cell contacts in complex biologies, building from new proteomic, imaging, computational and engineering approaches that are driving an unprecedented view of the molecular composition and dynamic nature of cell junctions, to ways that cell contacts guide polarity, mechanics and signaling within individual or neighboring cells, to studies of how communication among many cells governs morphogenesis, homeostasis and diseases of multicellular tissues. At every step the program will highlight new technologies, tools and approaches, while spotlighting the talent of young investigators.

Related Meeting

This GRC will be held in conjunction with the "Cell Contact & Adhesion" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Advancing the Field: Using New Technologies to Understand How Cell Contact Coordinates Signaling and Tissue Organization In Vivo
Discussion Leader: Andrea McClatchey (Harvard Medical School, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:40 pmJayaraj Rajagopal (Massachusetts General Hospital, USA)
"Notches, Niches and Plasticity"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmLate-Breaking Topic
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEstablishing Cell-Cell Contact: Molecular Composition
Discussion Leader: Andrew Ewald (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:20 amWilliam Weis (Stanford University, USA)
"Force-Dependent Molecular Interactions in Adherens Junction Assembly"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amChristina Van Itallie (National Heart, Lung, and Blood Institute, NIH, USA)
"Dynamic Protein Interactions in Tight Junction Formation and Maintenance"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amKathleen Green (Northwestern University, USA)
"Evolutionary Repurposing of Cadherins to Diversify Tissue Functions"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amPierre-Francois Lenne (Institut de Biologie du Développement de Marseille, France)
"Shaping Cell Contacts During Tissue Morphogenesis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Cara Gottardi (Northwestern University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEstablishing Cell-Cell Contact: Imaging/Modeling
Discussion Leader: Andrew Kowalczyk (Emory University, USA)
7:30 pm - 7:50 pmTatyana Svitkina (University of Pennsylvania, USA)
"Ultrastructural Analysis of the Cytoskeleton at Cell-Cell Contacts"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPakorn Kanchanawong (National University of Singapore, Singapore)
"Nanoscale Architecture of Cadherin-Based Cell Adhesions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKatie Bentley (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Modeling Differential Adhesion in Angiogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmImpact of Cell-Cell Contacts: Mechanical
Discussion Leader: Kathleen Green (Northwestern University, USA)
9:00 am - 9:20 amMargaret Gardel (The University of Chicago, USA)
"Zyxin Mediates Mechanochemical Feedback to Regulate Cell Elasticity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAdam Martin (Massachusetts Institute of Technology, USA)
"Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Force"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amChristopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Forces and Mechanotransduction in 3D Vascular Biology"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAlpha Yap (University of Queensland, Australia)
"Junctional Mechanotransduction and Epithelial Homeostasis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImpact of Cell-Cell Contacts: Polarity and Signaling
Discussion Leader: Alpha Yap (University of Queensland, Australia)
7:30 pm - 7:50 pmDavid Bryant (Beatson Institute for Cancer Research, United Kingdom)
"Functional Genomic Dissection of ARF GTPases in Polarized Invasion"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJames Salzer (New York University School of Medicine, USA)
"How Axo-Glial Interactions Direct the Formation of the Domains of Myelinated Axons"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKen Irvine (Waksman Institute of Microbiology, Rutgers University, USA)
"Regulation of Hippo Signaling by Cytoskeletal Tension"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJeffrey Axelrod (Stanford University School of Medicine, USA)
"Planar Cell Polarity Modulates Primary and Metastatic Tumor Cell Behavior in Drosophila"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCommunication Among Cells via Contacts: Principles and Homeostasis
Discussion Leader: Christopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
9:00 am - 9:20 amRoberto Mayor (University College London, United Kingdom)
"Front and Rear Forces During Collective Cell Migration"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnn Miller (University of Michigan, USA)
"Cell-Cell Junction Remodeling in Dividing Epithelial Cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amCarien Niessen (University of Cologne, Germany)
"Cadherin-Dependent Tissue Polarization in Morphogenesis and Homeostasis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSally Horne-Badovinac (University of Chicago, USA)
"Planar Cell-Cell Signaling Controlling Collective Cell Migration"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCommunication Among Cells via Contacts: Morphogenesis
Discussion Leader: Cara Gottardi (Northwestern University, USA)
7:30 pm - 7:50 pmMark Peifer (University of North Carolina at Chapel Hill, USA)
"Building the Body Plan - The Miracle of Morphogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChristin Kuo (Stanford University, USA)
"Formation of a Neurosensory Organ by Epithelial Cell Slithering"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDouglas Desimone (University of Virginia, USA)
"Adhesion and Mechanical Force in Collective Cell Migration"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJennifer Zallen (Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, USA)
"Generation of Tissue Structure Through the Collective Action of Cell Populations"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDefective Cell Contacts in Human Disease
Discussion Leader: Carien Niessen (University of Cologne, Germany)
9:00 am - 9:20 amCara Gottardi (Northwestern University, USA)
"Roles for the Developmentally Redundant AlphaT-Catenin in Asthma and Autism"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMatthew Tyska (Vanderbilt University School of Medicine, USA)
"Regulation of Brush Border Assembly Dynamics by Intermicrovillar Adhesion"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAndrew Kowalczyk (Emory University, USA)
"Desmosome Defects in Pemphigus"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMartin Schwartz (Yale School of Medicine, USA)
"Cell-Cell Adhesion Receptors in Vascular Mechanotransduction"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Contacts in Cancer Development and Progression
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pmGaudenz Danuser (University of Texas Southwestern Medical Center, USA)
"Relations Between Cell Shape Control and Survival in Melanoma"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJuliet Daniel (McMaster University, Canada)
"Role of the Catenin-Binding Transcription Factor Kaiso in Tumorigenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPanos Anastasiadis (Mayo Clinic, USA)
"Cadherin/RNAi Crosstalk in Epithelial Behavior and Human Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter