| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Unusual Natural Product Enzymology |
| Discussion Leader: Squire Booker (Pennsylvania State University, USA) |
| 7:40 pm - 8:10 pm | Bradley Moore (Scripps Institution of Oceanography, USA)
"Marine Natural Products as an Inspiration for New Biosynthetic Enzymology" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Gregory Challis (University of Warwick, United Kingdom)
"Elucidating and Exploiting Biosynthetic C-H Functionalization" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | David Christianson (University of Pennsylvania, USA)
"Structural Biology and Chemistry of Histone Deacetylases in Human Disease and Drug Discovery" |
| 9:20 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Large Complexes |
| Discussion Leader: Martin St. Maurice (Marquette University, USA) |
| 9:00 am - 9:30 am | Timm Maier (University of Basel, Switzerland)
"Structure and Evolution of Fatty Acid and Reducing Polyketide Synthases" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Shelley Minteer (University of Utah, USA)
"Substrate Channeling in Natural and Artificial Krebs Cycle Metabolons" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Group Photo / Coffee Break |
| 10:50 am - 11:05 am | Songon An (University of Maryland, Baltimore County, USA)
"A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: 'The Glucosome'" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Liang Tong (Columbia University, USA)
"Structure and Function of Large Metabolic Enzymes" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Lorenzo Finci (Tsinghua University, China)
"Structure and Function of the Spliceosome" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Unusual Coenzymes |
| Discussion Leader: Tadhg Begley (Texas A&M University, USA) |
| 7:30 pm - 8:00 pm | Paul Fitzpatrick (University of Texas Health Science Center, USA)
"Regulation of the Pterin-Dependent Aromatic Amino Acid Hydrolases" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Robert White (Virginia Tech, USA)
"Digging for Metabolic Fossils in the Methanogenic Archaea" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Hung-Wen Liu (University of Texas at Austin, USA)
"Characterization of a Cobalamin-Dependent Radical SAM Enzyme" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme Inhibition |
| Discussion Leader: Lynn Abell (Bristol-Myers Squibb, USA) |
| 9:00 am - 9:30 am | Dennis Murphy (Merck Research Laboratories, USA)
"Determination of In Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Benjamin Cravatt (Scripps Research Institute, USA)
"Enzyme and Inhibitor Discovery Using Chemical Proteomics" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Alan Rendina (GlaxoSmithKline, USA)
"A Fatty Acid Synthase KRyptonite for Structure, Mechanism and Cancer" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Brian Miller (Florida State University, USA)
"Allokairic Regulation of Enzyme Function" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Dali Liu (Loyola University Chicago, USA)
"Molecular Recognition of Pyruvate as an Allosteric Activator for ADP-Glucose Pyrophosphorylase from Agrobacterium tumefaciens" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Y. George Zheng (University of Georgia, USA)
"Mechanistic Insights of Protein Arginine Methyltransferases" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metalloenzymes |
| Discussion Leader: Catherine Goodman (Journal of Biological Chemistry, USA) |
| 7:30 pm - 8:00 pm | Pinghua Liu (Boston University, USA)
"Endoperoxide Formation by an a-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzyme" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Hideaki Ogata (Max Planck Institute for Chemical Energy Conversion, Germany)
"Catalytic Reaction Mechanism of [NiFe] Hydrogenase" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Amie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Determining Enzyme Function |
| Discussion Leader: Elham Behshad (Incyte Corp., USA) |
| 9:00 am - 9:30 am | Graham Moran (University of Wisconsin-Milwaukee, USA)
"Renalase, a Decade of Phantoms" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Reuben Peters (Iowa State University, USA)
"Mechanistic Insights from Systematic Investigation of (Di)Terpenoid Biosynthesis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:05 am | Rebecca Butcher (University of Florida, USA)
"Discovery and Biosynthesis of Hybrid Polyketide-Nonribosomal Peptides in Nematodes" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Valerie De Crecy-Lagard (University of Florida, USA)
"Discovering Novel and Missing Enzymes by Comparative Genomics" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Elizabeth Sattely (Stanford University, USA)
"Plant Pathway Discovery for Plant and Human Health" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Biocatalysis |
| Discussion Leader: Thomas Meek (Texas A&M University, USA) |
| 7:30 pm - 8:00 pm | Jon Stewart (University of Florida, USA)
"Understanding Alkene Reductases and Learning How to Make Them Better Biocatalysts" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Robert Dicosimo (DuPont Industrial Biosciences, USA)
"Enzymatic Production of Soluble Carbohydrate Fiber for Food Ingredient Applications" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Kevin Walker (Michigan State University, USA)
"Biocatalysis and Repurposing of Enzymes on Pathways to Bioactive Natural Products" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Assembly Lines |
| Discussion Leader: Barbara Gerratana (National Institute of General Medical Sciences, NIH, USA) |
| 9:00 am - 9:30 am | Sheryl Tsai (University of California, Irvine, USA)
"Structural Enzymology and Protein Dynamics of Fatty Acid, Polyketide, and Nonribosomal Peptide Megasynthases" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Steven Bruner (University of Florida, USA)
"Structure and Mechanism of the Transporter for the E. coli Genotoxin, Colibactin" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Charles Melancon (University of New Mexico, USA)
"A Bioinformatic Roadmap for Discovering and Engineering Type II Polyketide Biosynthetic Pathways and Enzymes" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Jorn Piel (Institute of Microbiology, ETH Zurich, Switzerland)
"Investigating and Utilizing trans-AT Polyketide Synthase Assembly Lines" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Andrew Gulick (Hauptman-Woodward Medical Research Institute, University at Buffalo, USA)
"Conformational Changes that Drive the Dynamic Structural Cycle of the Nonribosomal Peptide Synthetases" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Martin Schmeing (McGill University, Canada)
"Visualizing the First Steps of a Megaenzyme Making an Antibiotic" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Keynote Session: Learning from Naturally Gifted Enzymes |
| Discussion Leader: Karen Allen (Boston University, USA) |
| 5:30 pm - 6:20 pm | Debra Dunaway-Mariano (University of New Mexico, USA)
"Catalytic Diversity Among Phosphotransferases: Vignettes of Mechanism and Molecular Evolution" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Dale Poulter (University of Utah, USA)
"Biosynthesis of Squalene. Five Enzymes, Two Coenzymes, and a Metabolic Pathway" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
