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Fibronectin, Integrins & Related Molecules
Gordon Research Conference

The Regulation of Cell Behaviour by Cell-Extracellular Matrix Interactions

Dates

January 29 - February 3, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Charles H. Streuli

Vice Chairs:
Roy Zent & Johanna Ivaska

Meeting Description

The 2017 Gordon Research Conference on Fibronectin, Integrins and Cell-Matrix Signalling will be held between 29 January and 2 February in Ventura, California. This conference has emerged as the premier international scientific meeting for those interested in how the extracellular matrix guides cell and tissue function. The conference will explore the latest research that delineates the way cell-matrix adhesion is controlled, the contribution of the integrin adhesome to cell and tissue function in normal biology, and how cell-matrix adhesion becomes perturbed in diseases. A Gordon Research Seminar (GRS) in this research area, which is for PhD students and postdocs, will precede the conference on 28 and 29 January.

The Gordon Conference will encourage attendees to explore new research directions by showcasing the latest advances in imaging, biosensors, mechanobiology, developmental models, as well as clinical translation. The sessions will engage mid-career principle investigators in more that half of the presentations. They will also provide a forum for short talks selected from abstracts and those attending the Gordon Research Seminar, and for all investigators in poster sessions. Leaders in the field will participate as session chairs, and each of the conference talks will be accompanied by extensive discussion in order to enhance the impact of the meeting.

Related Meeting

This GRC was held in conjunction with the "Fibronectin, Integrins & Related Molecules" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Extracellular Matrix in Tissue Function
Discussion Leader: Charles Streuli (University of Manchester, United Kingdom)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:00 pmIntroduction by Discussion Leader
8:00 pm - 8:40 pmBilly Hudson (Vanderbilt University, USA)
"Evolutionary Dawn of the Extracellular Matrix and Epithelial Tissues"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHow Signals from the Matrix Control Cell Fate
Discussion Leader: Ambra Pozzi (Vanderbilt University School of Medicine, USA)
9:00 am - 9:20 amAlfred Nordheim (University of Tuebingen, Germany)
"Matrix Control of Liver Fibrosis"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amSelected from Poster Abstracts: Kate Herum (University of California, San Diego, USA)
"Mechanical Regulation of Fibroblast Pro-Fibrotic Phenotypes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amQing-Jun Meng (University of Manchester, United Kingdom)
"ECM-Dependent Circadian Clocks"
10:20 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amFlorian Bentzinger (University of Sherbrooke, Canada)
"Impaired Adhesion to the Stem Cell Niche ECM Affects the Regenerative Capacity of Aged Skeletal Muscle"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmPeter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Therapeutic Targeting of Integrins In Vivo"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Johanna Ivaska (University of Turku, Finland) and Ambra Pozzi (Vanderbilt University School of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMatrix Architecture and Cell Function
Discussion Leader: Christine-Maria Horejs (Karolinska Institutet, Sweden)
7:30 pm - 7:50 pmMichael Sherratt (University of Manchester, United Kingdom)
"Matrix Architecture in Ageing"
7:50 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmSelected from Poster Abstracts: Rishita Changede (Mechanobiology Institute, National University of Singapore, Singapore)
"Nanoclusters Are Building Blocks of Cell-Matrix Adhesions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChristopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Unveiling Adhesion Regulation Mechanisms Using Engineered Microenvironments"
8:50 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmAmbika Kurbet (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Sterile Inflammation Enhances EMC Degradation in Integrin β1 KO Embryonic Skin"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMechanotransduction
Discussion Leader: Andrew Chisholm (Wellcome Trust, United Kingdom)
9:00 am - 9:20 amMedhavi Vishwakarma (Max Planck Institute for Intelligent Systems, Germany)
"Mechanotransduction in Collective Cell Migration"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amSelected from Poster Abstracts: John Lamar (Albany Medical College, USA)
"Integrin/Src-Mediated YAP/TAZ Activation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJing Yang (University of California, San Diego, USA)
"Regulation of EMT and Tumour Metastasis by Matrix Stiffness"
10:20 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amValerie Weaver (University of California, San Francisco, USA)
"Mechanisms of Cancer Metastasis"
11:30 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Jose De Pereda (Institute for Molecular and Celular Biology of Cancer (CSIC-USAL), Spain)
"Interaction Between Integrin a6b4 and BPAG1e"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Coert Margadant (Sanquin Research, The Netherlands)
"A Novel Complex Regulating Integrin Sorting to Recycling Endosomes"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Extracellular Matrix and Stem Cells
Discussion Leader: Petra Gross (Journal of Cell Science, United Kingdom)
7:30 pm - 7:50 pmCharles ffrench-Constant (University of Edinburgh, United Kingdom)
"The Matrix in Neuronal Stem Cells and Fate"
7:50 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmSelected from Poster Abstracts: Johanna Englund (Institute of Biotechnology, University of Helsinki, Finland)
"BM Laminins Regulate Stemness by Guiding Asymmetric Cell Division"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAndres Garcia (Georgia Institute of Technology, USA)
"Engineering Synthetic ECMs for Stem Cells"
8:50 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmGregory Goreczny (SUNY Upstate Medical University, USA)
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Adhesion in Cancer
Discussion Leader: Bruce Rogers (Morphic Therapeutic, USA)
9:00 am - 9:20 amClare Isacke (Breast Cancer Now Research Centre, United Kingdom)
"Novel Metastasis Modulators Involving Stromal ECM"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amSelected from Poster Abstracts: Joseph Juan (Genentech, USA)
"Inhibiting Integrin α5β1 Modulates Matrix Formation in the Tumor"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amChris Madsen (Lund University, Sweden)
"ECM Remodelling During Cancer Progression and Metastasis"
10:20 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amJohn Marshall (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Integrins as Cancer Therapeutic Targets"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmJennifer Elisseeff (Johns Hopkins University, USA)
"Immunology of ECM-Derived Biomaterials in Regeneration and Cancer"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCell Migration
Discussion Leader: Tobias Zech (University of Liverpool, United Kingdom)
7:30 pm - 7:50 pmAmbra Pozzi (Vanderbilt University School of Medicine, USA)
"Talin Regulates Discoidin Domain Receptor1-Mediated Cell Junctions"
7:50 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmSelected from Poster Abstracts: Guillaume Jacquemet (University of Turku, Finland)
"Myosin-X Filopodia and Cancer Cell Invasion"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmNils Gauthier (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Cell Migration in Fibrous Microenvironments"
8:50 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmNisha Mohd Rafiq (Mechanobiology Institute, Singapore)
"ARF1-Induced Myosin II Suppresion of Podosomes"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntegrin Trafficking
Discussion Leader: Johanna Ivaska (University of Turku, Finland)
9:00 am - 9:20 amLudger Johannes (Institut Curie, France)
"Endocytic Uptake and Retrograde Trafficking of Focal Adhesion Proteins"
9:20 am - 9:40 amDiscussion
9:40 am - 9:50 amSelected from Poster Abstracts: Stephanie Kermorgant (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Co-Trafficking of Beta 1-Integrin and c-Met Promote Cancer Cell Survival"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRalph Boettcher (Max Planck Institute of Biochemistry, Germany)
"Analyzing Integrin Trafficking and Its Role for Integrin Function and Stability"
10:20 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amDavid Lyden (Weill Cornell Medicine, USA)
"Exosomes and Metastasis"
11:30 am - 11:50 amDiscussion
11:50 am - 12:10 pmJim Norman (Beatson Institute, University of Glasgow, United Kingdom)
"Integrins and Trafficking"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: How the Adhesome Works
Discussion Leader: Roy Zent (Vanderbilt University Medical Center, USA)
7:30 pm - 7:40 pmBen Goult (University of Kent, United Kingdom)
"Talin as a Mechanosensitive Signaling Platform"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmRoland Thuenauer (University of Freiburg, Germany)
"Unraveling Integrin Sorting in Epithelial Cells by Synchronizing Integrin Trafficking"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:50 pmMark Ginsberg (University of California, San Diego, USA)
"Deconvoluting the Adhesome"
8:50 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible by 1R13AR071167-01 the National Institutes of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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