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Lipids, Molecular & Cellular Biology of
Gordon Research Conference

Lipid Dynamics and Lipidomics

Dates

July 26-31, 2015

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Suzanne Jackowski

Vice Chair:
David A. Bernlohr

Meeting Description

The Gordon Research Conference on Molecular and Cellular Biology of Lipids provides an opportunity for scientists to present and discuss their research in lipid biology and metabolism. The meeting will be held July 26-31 at the Waterville Valley Resort in Waterville Valley, New Hampshire. This conference will include nine lecture sessions and four afternoon poster sessions that highlight fundamental aspects of Lipid Dynamics and Lipidomics at the molecular, cellular and organismal levels. Current perspectives on a broad range of topics will be covered in lectures by established and emerging leaders, and short oral presentations from young investigators will be selected from submitted poster abstracts. The topics include membrane lipid-protein interactions, new technology in cellular lipid imaging, lipid trafficking, signaling, implementation of lipidomics for investigation of disease mechanisms and how microbes hijack host lipid metabolism. Attendees from diverse disciplines traditionally engage in lively discussions that encompass biochemistry, structural biology, cell biology, microbiology, physiology and genetics. Attendees benefit from the high quality of the speakers, the diverse experimental backgrounds of the participants and the numerous afternoon recreational activities that are available for informal interactions. One goal of the conference is to advance understanding of how the dynamics of lipid metabolism contribute to the regulation of biological structure and function, with an eye toward future medical applications.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Lipid Dynamics and Lipidomics
Discussion Leader: Suzanne Jackowski (St. Jude Children's Research Hospital, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmTodd Graham (Vanderbilt University, USA)
"Probing How and Why P4-ATPases Flip Phospholipid"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmDaniel Nomura (University of California, Berkeley, USA)
"Mapping Dysregulated Lipid Metabolism in Disease Using Chemoproteomic and Metabolomics Platforms"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Trafficking of Lipids
Discussion Leader: George Carman (Rutgers University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amThomas Langer (University of Cologne, Germany)
"Intramitochondrial Phospholipid Trafficking"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amMadhavan Chalat (University of British Columbia, Canada)
"C-Terminal Domain of Atp8a2 Is Involved in Auto-Regulation of Flippase Activity"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amGroup Photo / Coffee Break
10:40 am - 11:15 amSymeon Siniossoglou (University of Cambridge, United Kingdom)
"Coordination of Membrane and Storage Lipid Homeostasis by Lipin"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amMasaki Tsuchiya (Graduate School of Engineering, Kyoto University, Japan)
"The Role of Phospholipid Flippases in Myotube Formation"
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmWill Prinz (National Institutes of Health, USA)
"ER-Golgi Contacts and Ceramide Toxicity"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLipid Responses to Challenge
Discussion Leader: Daniel Raben (Johns Hopkins University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmNan Chiang (Harvard Medical School, USA)
"Novel Actions of Specialized Pro-Resolving Mediators in Promoting Resolution of Inflammation and Infection"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmGregory Fairn (St. Michael's Hospital, University of Toronto, Canada)
"Mutual Requirement of Cholesterol and Phosphatidylserine in the Cytosolic Leaflet of the Plasma Membrane"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmFrank Gonzalez (National Cancer Institute, NIH, USA)
"Ceramides and Metabolic Disease"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipid Signaling
Discussion Leader: Dennis Voelker (National Jewish Health, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amLois Weisman (University of Michigan, USA)
"Role and Regulation of PI(3,5)P2 and PI5P: Signaling Lipids with Links to Neurodegeneration"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amScott Hansen (The Scripps Research Institute, USA)
"Lipid Gating of Ion Channels"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amRajat Rohatgi (Stanford University School of Medicine, USA)
"Signal Transduction by Oxysterols"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amXinxin Gao (Genentech, USA)
"Single-Cell In Situ Imaging of Wnt Palmitoylation"
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmRichard Proia (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Imaging Sphingolipid Signaling in Live Mice"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmResponses to Lipid Challenge
Discussion Leader: Paul Black (University of Nebraska, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmTobias Walther (Harvard T.H. Chan School of Public Health, USA)
"Molecular Mechanisms and Consequences of Cellular Neutral Lipid Storage"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmStephen Jesch (Cornell University, USA)
"Inositol-Dependent Changes in Sphingolipid Metabolism Regulate Stress Response Signaling"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmClay Semenkovich (Washington University, USA)
"Lipogenesis, Metabolic Signaling, and Adaptation to Obesity"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDisease Mechanisms
Discussion Leader: Rosalind Coleman (University of North Carolina, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amMichael Schlame (New York University School of Medicine, USA)
"Aberrant Cardiolipin Dynamics in Barth Syndrome"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amMartin Pagac (University of New South Wales, School of Biotechnology and Biomolecular Sciences, Australia)
"SEIPIN Is an Evoluationarily Conserved Regulator of Glycerol-3-Phosphate Acyltransferase (GPAT)"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amMichael Wolfgang (Johns Hopkins University, USA)
"Role of Adipocyte Fatty Acid Oxidation in Obesity and Diabetes"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amBaran Ersoy (Brigham and Women's Hospital / Harvard Medical School, USA)
"Regulation of Endoplasmic Reticulum (ER) Calcium Homeostasis by Thioesterase Superfamily Member 2 (Them2): Pathogenic Role in Non-Alcoholic Fatty Liver Disease (NAFLD)"
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmNoa Noy (Cleveland Clinic, USA)
"Long Chain Fatty Acids Regulate Transcription and Modulate Cancer Cell Growth by Targeting FABP5"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTargeting Lipid Metabolism
Discussion Leader: Judith Storch (Rutgers University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmAlex Brown (Vanderbilt University, USA)
"Phosphatidic Acid Pathways as Therapeutic Targets in Cancer and Infectious Disease"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmAlenka Copic (Institute Jacques Monod, CNRS UMR 7592, France)
"How Differential Membrane Lipid Composition Is Maintained in Cells and Used for Selective Recruitment of Amphipathic Helices"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmMichael Wakelam (University of Cambridge, United Kingdom)
"Lipidomic Analysis of Cancer Cells and Tissues"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmMicrobial Interaction with Host Lipid Metabolism
Discussion Leader: James Ntambi (University of Wisconsin-Madison, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amAndrew Tai (University of Michigan Medical School, USA)
"Reorganizing Cellular Membranes to Support RNA Virus Replication"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amSwapna Apte (Purdue University, USA)
"Functions of Specific Sphingolipids in Dengue Virus Infection"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amDennis Voelker (National Jewish Health, USA)
"Anionic Phospholipid Protection from Respiratory Virus Infections"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amDaniel Ferguson (Cleveland Clinic Foundation, USA)
"Hepatitus C Virus-Driven Depatic Steatosis Requires the Lipid Droplet Scaffold Protein TIP47"
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmCharles Rock (St. Jude Children's Research Hospital, USA)
"Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTechnological Advances in Lipid Biology
Discussion Leader: David Bernlohr (University of Minnesota, Twin Cities, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmArthur Laganowsky (Texas A&M Health Science Center, USA)
"Advances in Ion Mobility Mass Spectrometry of Intact Membrane Protein-Lipid Complexes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmPaul Black (University of Nebraska, USA) and Alan Kleinfeld (Membrane Sciences, USA)
"Unbound FFA Profiles as a New Window on Physiological Active Metabolites"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPeter Watson (Cardiff University School of Biosciences, United Kingdom)
"Hyperspectral and Differential CARS Microscopy for Quantitative Imaging of Cellular Lipids"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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