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Phosphorylation and G-Protein Mediated Signaling Networks
Gordon Research Conference

Regulation of Kinases and G Proteins in Normal, Pathological, and Synthetic Systems

Dates

June 15-20, 2014

Location

University of New England
Biddeford, ME

Organizers

Chair:
Melanie H. Cobb

Vice Chair:
Carmen W. Dessauer

Meeting Description

The primary purpose of the 2014 GRC on Phosphorylation and G Protein-mediated Signaling Networks is to bring together leading innovators and early stage investigators to facilitate the exchange of ideas, challenge dogma, and develop productive collaborations to enhance scientific discovery. The program draws upon scientists with a wide range of interests in different properties, systems, and components of signal transduction pathways. Presentations will explore molecular mechanisms and signaling networks underlying diverse aspects of physiology and pathology. The focus will be on unpublished research. We will stress new strategies to decipher formerly intractable problems in signal transduction and include pathways of great physiological impact that are under-explored.

Related Meeting

This GRC was held in conjunction with the "Phosphorylation and G-Protein Mediated Signaling Networks" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Carmen Dessauer (UTHSC Houston)
7:40 pm - 8:10 pmFrank McCormick (UCSF)
"Ras"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmJohn Scott (University of Washington)
"Guiding Signals Through Anchored Enzyme Complexes"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmMichael Sussman (University of Wisconsin, Madison)
"Plant Kinases and Receptors: Life Without Mobility"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmKinases and G Proteins in Development
Discussion Leader: Carol Lange (University of Minnesota)
9:00 am - 9:25 amJoe Avruch (Harvard Medical School)
"The Mst1/Mst2 Kinases - The Hippo Pathway and More"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSwathi Arur (M.D. Anderson Cancer Center)
"ERK Substrate Networks During Germ Cell Development"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amStacey Ogden (St. Jude's CRH)
"Control of Smoothened Signal Induction"
10:35 am - 10:45 amDiscussion
10:45 amCoffee Break
11:00 am - 11:25 amSaikat Mukhopadhyay (UT Southwestern Medical Center)
"GPCRs, Hedgehog Signaling, and the Primary Cilium"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmCarol Lange (University of Minnesota)
"Noncanonical Actions of Progesterone Receptor Modifications"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmKeqiang Xie (Scripps Florida)
"Neurofibromin Is an Effector and Regulator of GPCR Signaling in the Nervous System"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cell Signaling
Discussion Leader: Rebecca Berdeaux (UT Health Science Center at Houston)
7:30 pm - 7:50 pmAnne Brunet (Stanford)
"Epigenetic Regulation of Stem Cell Maintenance and Rejuvenation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmYukiko Gotoh (University of Tokyo)
"Neural Stem Cell Development"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChristophe Frémin (University of Montreal)
"Redundant Functions of ERK1 and ERK2 MAPKs in Development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRebecca Berdeaux (UT Health Science Center at Houston)
"Regulation and Function of SIK1 in Myogenesis and Metabolism"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmKinases and G Proteins Controlled by Pathogens and Stress
Discussion Leader: Jessie English (DFCI, Belfer Institute, HMS)
9:00 am - 9:25 amAnton Bennett (Yale)
"MAP Kinase Phosphatases in Disease Signaling"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amMarsha Rosner (University of Chicago)
"RKIP Bridges MAPK and G Protein-Mediated Pathways"
9:45 am - 9:50 amDiscussion
9:50 am - 10:00 amAndres Norambuena (University of Virginia)
"A Rac1-mTOR Pathway Controls Amyloid-Beta Induced, Tau-Dependent, Ectopic Cell Cycle Re-Entry, a Major Cause of Neuron Death in Alzheimer's"
10:00 am - 10:05 amDiscussion
10:05 am - 10:15 amJing Liu (Northwestern)
"Suppression of Inflammation by the Transcription Factor Miz1"
10:15 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:15 amNeal Alto (UT Southwestern Medical Center)
"Bacterial Pathogenesis Through G Protein De-Myristoylation"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amSantiago Vernia (University of Massachusetts)
"Metabolic Stress Signaling by JNK"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmNatalia Jura (UCSF)
"Regulation of Allosteric Function of HER/ErbB Receptors"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBiosynthetic Interactions of Kinases and G Proteins
Discussion Leader: Alexandra Newton (UCSD)
7:30 pm - 7:50 pmAnabela Srebrow (Universidad de Buenos Aires, Argentina)
"Post-Translation Modifications Influence the Splicing Machinery and Vice Versa"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmXuewu Zhang (UT Southwestern Medical Center)
"How Plexins GAP Rap"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmEstela Jacinto (Rutgers University)
"mTORC2 in Cellular Metabolism"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAlexandra Newton (UCSD)
"Functions of Protein Kinase C in Cancer"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmG Protein and Kinase Diversity and Control Mechanisms
Discussion Leader: Anne-Claude Gingras (Samuel Lunenfeld Research Institute, University of Toronto)
9:00 am - 9:25 amCarmen Dessauer (UT Health Science Center at Houston)
"Sensitization of Neuronal cAMP Signaling by Anchored Adenylyl Cyclase Complexes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDavid Robbins (University of Miami)
"Casein Kinase I As a Therapeutic Target"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amPatrick O'Neill (Washington University)
"Subcellular Optogenetics: Asymmetric G Protein Inhibition Induces Polarity"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
10:45 am - 11:10 amMichael Reese (UT Southwestern Medical Center)
"Virulence Without Catalysis: How Noncatalytic Secreted Effectors Enable Toxoplasma to Foil the Immune System"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amAnne-Claude Gingras (Samuel Lunenfeld Research Institute, University of Toronto)
"Proteomics of Dephosphorylation Networks"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmLiam Holt (UC Berkeley)
"Ancestral Resurrection Reveals Mechanisms of Kinase Plasticity"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmKinases and G Proteins in Cancer
Discussion Leader: Natalie Ahn (University of Colorado, Boulder)
7:30 pm - 7:50 pmNatalie Ahn (University of Colorado, Boulder)
"ERK2 Conformational States and Control of Activity"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJean Wang (UCSD)
"Abl and Apoptosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGray Pearson (UT Southwestern Medical Center)
"G Proteins Affecting Cell Identity in Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmElizabeth Goldsmith (UT Southwestern)
"Chloride Regulates WNK1 by Inhibition of Autophosphorylation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDetection and Manipulation of Kinase and GPCR Signaling
Discussion Leader: Jin Zhang (Johns Hopkins University)
9:00 am - 9:25 amJin Zhang (Johns Hopkins University)
"Compartmentalized Kinase and Phosphatase Signaling in Living Cells"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJurgen Wess (NIH)
"Cell Type-Selective Manipulation of GPCR Signaling Pathways In Vivo"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amRony Seger (Weizmann Institute)
"GqPCR-Induced Apoptosis Is Mediated by an Inactivation of PI3K/AKT via a PP2A Switch"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
10:45 am - 11:10 amNatalia Riobo (Thomas Jefferson University)
"G Protein-Mediated Regulation of Cardiac Physiology by Smoothened"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amPiero Crespo (Universidad de Cantabria, Spain)
"Ras Signals at the Golgi Induce Apoptosis"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmCarol Chresterson (Kennesaw State University)
"eNOS Regulation by Rsk"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPascal Charest (University of Arizona)
"The Small GTPase Rap1 Binds to and Activates TORC2"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructures, Models, Networks
Discussion Leader: Melanie Cobb (UT Southwestern Medical Center)
7:30 pm - 7:50 pmWalter Kolch (University College, Dublin, Ireland)
"Global and Local Rewiring of Signal Transduction Networks by Oncogenic Mutations"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmStephan Knapp (University of Oxford, England)
"Strategies for Rational Design of Specific Chemical Probes for Protein Kinases"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRon Dror (Stanford University)
"Revealing Activation Mechanisms of GPCRs and G Proteins Through Simulation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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