Gordon Research Conferences
Meeting Details
Search:
  GO

Plasminogen Activation & Extracellular Proteolysis
Gordon Research Conference

Biological Functions and Translational Importance of Plasminogen Activation and Extracellular Proteolysis

Dates

February 11-16, 2018

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA Site Information

Organizers

Chair:
Manuel Yepes

Vice Chairs:
Stella E. Tsirka & Marie Ranson

Application Deadline

Applications for this meeting must be submitted by January 14, 2018. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The main goal of this meeting is to present breakthrough findings on the biological functions of plasminogen activation and extracellular proteolysis and to discuss their translational importance in distinct scientific areas: vascular biology, neurobiology, neurodegeneration, cell death, pregnancy, cardiovascular and renal function, inflammation, infection, tissue homeostasis and regeneration, tumor biology, cardiovascular function, and angiogenesis. Each topic will be addressed within a conceptual framework assembled by three "T's": Translational, Technological and Transitional. The Translational goal will be met by in-depth discussions of the translational importance of the new discoveries presented in each session and the identification of those basic research areas that need to be developed in the future to meet specific clinical needs. These discussions will be accompanied by the presentation and discussion of state-of-the-art Technological advances in proteomics, genomics and imaging. Finally, to promote a Transition to a new generation of investigators, each session will be assembled by a mixed group of senior and younger speakers.

Related Meeting

This GRC will be held in conjunction with the "Plasminogen Activation & Extracellular Proteolysis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
University of Wollongong
American Society for Pharmacology and Experimental Therapeutics (ASPET) - Division for Molecular Pharmacology

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Translational Impact of More than 80 Years of Research on Plasminogen Activation and Extracellular Proteolysis
Session in memory of Peter Andreasen.
Discussion Leader: Tor Ny (Umea University, Sweden)
7:40 pm - 8:25 pmHau Kwaan (Feinberg School of Medicine, Northwestern University, USA)
"From Fibrinolysis to the Plasminogen Activation and Beyond"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBenjamin Cravatt (Scripps Research Institute, USA)
"Activity-Based Proteomics-Enzyme and Ligand Discovery on a Global Scale"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSelen Catania (University of Maryland, Baltimore, USA)
"A Novel Role for LRP1 in Vessel Wall Homeostasis: Insight from Rare Genetic Variants"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProteases in Neurobiology: From the Synapse to the Bedside
Discussion Leader: Katerina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA)
9:00 am - 9:30 amStella Tsirka (Stony Brook University, USA)
"Microglial Proteases and CNS Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amRobert Pawlak (University of Exeter, United Kingdom)
"Control of Anxiety by Plasmin-Mediated Cleavage of EphA4 at the Amygdala Synapses"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amWendy Campana (University of California, San Diego, USA)
"LRP1-Signaling in Nervous System Injury"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amDenis Vivien (INSERM, France)
"Giving New Life to Old Music: Novel Functions of tPA in the Neurovascular Unit"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmMark Petersen (Gladstone Institutes / University of California, San Francisco, USA)
"Role of Fibrinogen in Impaired CNS Development and Regeneration"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProteases in Cardiovascular and Renal Function
Discussion Leader: Douglas Vaughan (Northwestern University, USA)
7:30 pm - 7:50 pmJochen Reiser (Rush University, USA)
"suPAR: Biomarker and Biomaker of Kidney Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTetsumei Urano (Hamamatsu University School of Medicine, Japan)
"Regulatory Mechanisms of the Initiation and Amplification of Fibrinolysis on Cell Surface by TAFI and PAI-1: Demonstration by Real-Time Imaging Analysis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWilliam Fay (University of Missouri, USA)
"Proteolytic Signaling Pathways in Obesity-Associated Cardiovascular Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmNicola Mutch (University of Aberdeen, United Kingdom)
"The Fibrinolytic Capacity of Platelets"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteases in Inflammation, Infection and Pregnancy
Discussion Leader: David Ginsburg (University of Michigan, USA)
9:00 am - 9:30 amFrancis Castellino (University of Notre Dame, USA)
"The Subversion of the Host Innate Immune System by S. pyogenes Promotes Its Survival and Virulence"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSteven Gonias (University of California, San Diego, USA)
"Regulation of Innate Immunity by the Fibrinolysis System"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amWyndham Lathem (Institut Pasteur, France)
"The Double-Edged Sword: How Plasminogen both Helps and Hurts During Gram-Negative Bacterial Infections"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amEric Mullins (Cincinnati Children's Research Foundation, USA)
"Plasminogen and Fibrinolysis in Neuroinflammation"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmAmy Wyatt (University of Wollongong, Australia)
"Non-Canonical Functions of Pregnancy-Associated Protease Inhibitors"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructure and Function of Proteases, Receptors and Inhibitors
Discussion Leader: Thomas Bugge (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 7:50 pmLindsey Miles (Scripps Research Institute, USA)
"The Plasminogen Receptor, Plg-RKT, and ECM Remodeling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKatherine Hajjar (Weill Cornell Medicine, USA)
"The Expanding Repertoire of Annexin A: Old Dogs and New Tricks"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmToni Antalis (University of Maryland School of Medicine, USA)
"Membrane-Anchored Serine Proteases in Angiogenesis and Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmQingyu Wu (Lerner Research Institute, Cleveland Clinic, USA)
"Membrane-Bound Serine Proteases in Liver Metabolism"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteases in Cancer
Discussion Leader: Steven Gonias (University of California, San Diego, USA)
9:00 am - 9:30 amWouter Moolenaar (Netherlands Cancer Institute, The Netherlands)
"Suppression of Malignant Cell Behavior Through GPI-Anchor Cleavage"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amMatthew Flick (Cincinnati Children's Hospital Medical Center, USA)
"Linking Anticoagulation and Plasminogen Activation Pathways in Pancreatic Ductal Adenocarcinoma"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amJaime Merchan (Miller School of Medicine, University of Miami, USA)
"Molecular Effects of uPAR-Mediated Stromal Targeting by Oncolytic Measles Virus"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amMichael Ploug (Rigshospitalet, Denmark)
"Structure-Based Design of uPAR-Targeting Peptides and Their Clinical Translation as Non-Invasive Imaging Tools in Solid Cancers"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmMaria Patrizia Stoppelli (National Research Council, Italy)
"Modulating the Pro-Invasive Activity of Fibroblasts in Tumor-Stroma Crosstalk"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics
Discussion Leader: Marie Ranson (University of Wollongong, Australia)
7:30 pm - 7:40 pmLate-Breaking Topic
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLate-Breaking Topic
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmLate-Breaking Topic
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmLate-Breaking Topic
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmLate-Breaking Topic
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmLate-Breaking Topic
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLate-Breaking Topic
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLate-Breaking Topic
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteases in Aging, Cell Death and Neurodegeneration
Discussion Leader: Paul Declerck (University of Leuven, Belgium)
9:00 am - 9:30 amJoachim Herz (University of Texas Southwestern Medical Center, USA)
"Translational Approaches to Alzheimer's and Frontotemporal Dementia"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSidney Strickland (The Rockefeller University, USA)
"Vascular Contributions to Alzheimer's Disease"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amDavid Granville (University of British Columbia, Canada)
"Granzyme Serine Proteases in Aging and Chronic Disease"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amRobert Medcalf (Monash University, Australia)
"Anti-Fibrinolytic Agents, Cell Death and the Immune Response"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmDouglas Vaughan (Northwestern University, USA)
"PAI-1 and Aging-Related Morbidity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Technologies and Therapeutic Advances in Plasminogen Activation and Extracellular Proteolysis
Discussion Leader: William Fay (University of Missouri, USA)
7:30 pm - 7:50 pmJacob Corn (University of California, Berkeley, USA)
"CRISPR-Cas9, from Mechanism to Therapy"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmVladimir Muzykantov (University of Pennsylvania, USA)
"Targeted Interventions in Hematological Proteolysis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDaniel Lawrence (University of Michigan, USA)
"Clinical Targeting of Cerebrovascular Pathways in Ischemic Stroke"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmPaul Declerck (University of Leuven, Belgium)
"Preclinical Development of a Biospecific Profibrinolytic Agent"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter