Gordon Research Conferences
Meeting Details
Search:
  GO

Matrix Metalloproteinases
Gordon Research Conference

Rediscovering Metalloproteinases as Disease Targets

Dates

July 9-14, 2017

Location

University of New England
Biddeford, ME Site Information

Organizers

Chair:
Howard C. Crawford

Vice Chair:
Rama Khokha

Application Deadline

Applications for this meeting must be submitted by June 11, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Since their discovery as tissue remodeling enzymes over 50 years ago, the matrix metalloproteinases (MMPs) and the related ADAM and ADAMTS families have been identified as major contributors to human diseases, ranging from inflammatory diseases to neurodegeneration to cancer. Once viewed monolithically as bad actors in disease progression, they were collectively thought to be an ideal drug target, especially to prevent tumor invasion and metastasis or to block tissue destruction in chronic inflammatory conditions. However, early clinical trials with metalloproteinase inhibitors were unsuccessful for a number of likely reasons, the most prominent being a lack of appreciation for the more nuanced functions of individual metalloproteinases. Indeed, while some metalloproteinases may promote disease processes, we now understand that others act to protect against disease morbidity, facilitate repair, dampen inflammation, and support other beneficial functions, contraindicating the use of broad-spectrum inhibitors. Hence, a common goal in the field has been to discover specific functions of specific MMPs and how their activities and substrate interactions are controlled, with the aim of identifying specific deleterious activities that can be targeted with new, rational therapies. The aim of this GRC is to highlight the investigative advances dissecting both the good and bad functions of individual MMPs and the many ways their activities are controlled by endogenous mechanisms. Discussions will explore new directions for investigations and highlight how these fundamental discoveries can lead to the design of novel, specific metalloproteinase-targeted modulators for the treatment of human disease.

Related Meeting

This GRC will be held in conjunction with the "Matrix Metalloproteinases" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Metalloproteinases in the Clinic
Discussion Leader: Barbara Fingleton (Vanderbilt University, USA)
7:40 pm - 8:20 pmIrit Sagi (Weizmann Institute of Science, Israel)
"The Return of MMP Inhibitors in Therapy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmVictoria Smith (Gilead Sciences, USA)
"Making the Case for GS-5745, an Anti-MMP9 Antibody Currently in Cancer Clinical Trials"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmNoopur Raje (Harvard Medical School, USA)
"Rehabilitating a Lost Drug - The Story of Thalidomide"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloproteinases in Tissue Remodeling
Session in memory of Dr. Roger Tsien.
Discussion Leader: Suneel Apte (Cleveland Clinic, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amStephen Adams (University of California, San Diego, USA)
"Protease-Triggered Cancer Imaging and Therapy"
9:20 am - 9:25 amDiscussion
9:25 am - 9:40 amVarda Lev-Ram (University of California, San Diego, USA)
"Could Life-Long Memory Be Encoded in the Pattern of Holes in the Perineuronal Net?"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amShort Talk Selected from Poster Abstracts
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amCoffee Break
10:25 am - 10:45 amBi-Sen Ding (Weill Cornell Medicine, USA)
"Regulation of Organ Regeneration and Fibrosis by Vascular-Derived MMPs"
10:45 am - 10:55 amDiscussion
10:55 am - 11:15 amStefan Lichtenthaler (Technical University of Munich, Germany)
"ADAM10 Substrates and Functions in Axon Targeting and Myelenation"
11:15 am - 11:25 amDiscussion
11:25 am - 11:45 amSantiago Rivera (Aix-Marseille University / CNRS, France)
"MT-MMPs, New Actors and Potential Targets in Alzheimer's Disease"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rama Khokha (University of Toronto, Canada)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBeyond the Catalytic Site: Endogenous Regulation of ADAM Activity
Discussion Leader: Carl Blobel (Hospital for Special Surgery, Weill Cornell Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmMatthew Freeman (University of Oxford, United Kingdom)
"Molecular Mechanisms and Biological Roles of iRhom/ADAM17 Signaling"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMichael Tomlinson (University of Birmingham, United Kingdom)
"Regulation of ADAM10 by Tetraspanins"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmDennis Selkoe (Brigham and Women's Hospital, USA)
"Physical and Functional Interaction Between the Alpha- and Gamma-Secreatases: A New Model of Regulated Intramembrane Proteolysis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmStephen Blacklow (Harvard Medical School, USA)
"Structural Basis for Regulated Proteolysis by the Alpha-Secretase ADAM10"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMMPs and TIMPs as Targets and Anti-Targets in Cancer
Discussion Leader: Sharon Stack (University of Notre Dame, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amAchim Kruger (Rechts der Isar Hospital, Technical University of Munich, Germany)
"TIMP-1 Signaling as an Accomplice in Liver Metastasis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amBarbara Fingleton (Vanderbilt University, USA)
"A Perplexing Target: Opposing Functions of MMP10 in Colon Cancer"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amChristopher Overall (University of British Columbia, Canada)
"Tumor Associated Macrophage MMP12 Cleaves Intracellular Tumor Oncogene Targets Preventing Cancer Inititiation"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amLate-Breaking Topic
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMMPs: Critical Effectors in Inflammation
Discussion Leader: Christopher Overall (University of British Columbia, Canada)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmWilliam Parks (Cedars-Sinai Medical Center, USA)
"MMP10 Drives the Immunosuppressive Activity of Macrophages"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmAthan Kuliopulos (Tufts University, USA)
"MMP1 Signaling Through Protease-Activated Receptor-1 in Systemic and Vascular Inflammation"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmZhongjun Zhou (The University of Hong Kong, Hong Kong SAR China)
"MT-MMP Sheds LYVE-1 and Suppresses VEGF-C Production to Inhibit Lymphangiogenesis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Approaches to Translate Discoveries to Targeted Therapies
Discussion Leader: William Parks (Cedars-Sinai Medical Center, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amJoseph Castellano (Stanford University School of Medicine, USA)
"Systemic TIMP2 Treatment Improves Hippocampal Function in Aged Mice"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amGuy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Unique Activity Profiles of Inflammatory Proteases"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amGregg Fields (Florida Atlantic University, USA)
"MMP Structural Biology for Guiding Selective Inhibitor Design"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amLate-Breaking Topic
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmExploiting Metalloproteinase Activity for Diagnosis and Treatment of Disease
Discussion Leader: Dylan Edwards (University of East Anglia, United Kingdom)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmPaul Loadman (University of Bradford, United Kingdom)
"Exploiting Tumor Metalloproteinase Expression for Selective Drug Targeting"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmGhislain Opdenakker (University of Leuven, Belgium)
"Gelatinase B or MMP-9: From Target to Useful Disease Marker"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJeanine D'Armiento (Columbia University, USA)
"MMPis as a Tool for Functional Lung Imaging"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBeyond the Catalytic Site: Endogenous Regulation of Metalloproteinases
Discussion Leaders: Gillian Murphy (University of Cambridge, United Kingdom) and Hideaki Nagase (University of Oxford, United Kingdom)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amStefan Linder (Medical Center Hamburg-Eppendorf, Germany)
"MT1-MMP Transport and Structural Memory in Macrophages"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amStephen Weiss (University of Michigan, USA)
"Exocyst-Dependent Control of MT-MMP Trafficking: The Trans-Golgi-to-Invadapodia Highway"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amChristoph Becker-Pauly (University of Kiel, Germany)
"Shedding and Activation of Meprin Beta Regulates Intestinal Host Defense"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amLate-Breaking Topic
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Approaches in Protease-Driven Diseases
Discussion Leader: Andreas Herrlich (Harvard Medical School, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmJuliane Bubeck Wardenburg (University of Chicago, USA)
"Protease Inhibition for the Treatment of Sepsis"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmJonathan Larkin (GlaxoSmithKline, United Kingdom)
"Targeting ADAMTS-5 in Osteoarthritis"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmStefan Rose-John (University of Kiel, Germany)
"ADAM17 in the Control of Inflammation and Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmGeneral Discussion
9:25 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter