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Glycolipid and Sphingolipid Biology
Gordon Research Conference

Glycolipid and Sphingolipid Homeostasis and Function in Health and Disease

Dates

March 6-11, 2016

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Howard Riezman

Vice Chair:
Mark Kester

Meeting Description

The 14th Gordon Research Conference on Glycolipid and Sphingolipid Biology will be held from March 6-11, 2016 at the Renaissance Tuscany Resort in Il Ciocco, a lovely Italian countryside location, which provides an ideal location for scientific discussion. This conference is the primary international venue in the field of glycolipid/sphingolipid biology. We will have an excellent program covering a wide range of topics with an emphasis on mechanistic insights into physiological processes where glycolipids and sphingolipids play a prominent role. A number of prominent speakers have been invited, but most sessions have time slots reserved for late-breaking topic talks chosen among the submitted abstracts.

The conference will begin with a Forward Looking Session that evaluates the progress we have made in the field and highlights the most important challenges for the future. The progress previously made on glycolipid and sphingolipid enzymology will be extended to address how these pathways are regulated and controlled spatially. Progress in science is frequently related to the availability of suitable technology and new developments will be covered. Glycolipids and sphingolipids have emerged as important factors in many physiological processes, including apoptosis, autophagy, regulation of metabolism, cell migration, and are important in several diseases, including bacterial and viral infections, type 2 diabetes, multiple inflammatory diseases and cancer. A large part of the program will be dedicated to understanding the roles of lipids in physiology and the translational efforts to move these findings to the clinic.

In the past, the conference has been fully subscribed with an excellent mix of established academic researchers, attendees from industry and young scientists. The poster sessions are an important part of the conference and several young investigators will be chosen to give oral presentations. Ample discussion time will be provided within the sessions and hopefully, during the lovely afternoons in the Italian countryside.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmUnderstanding Complex Networks in Membranes and Glyco/Sphingolipid Homeostasis
Discussion Leaders: Walter Holleran (VA Medical Center / University of California, San Francisco, USA) and Yasuyuki Igarashi (Hokkaido University, Japan)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:15 pmYusuf Hannun (Stony Brook University, USA)
"Neutral Sphingomyelinase in the DNA Damage Response"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmGiulio Superti-Furga (Center for Molecular Medicine, Austrian Academy of Sciences, Austria)
"The Circular Network of Coregulated Lipids in Cellular Signaling and Drug Action"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmAuxiliadora Aguilera Romero (University of Geneva, Switzerland)
"Cross-Talk Between Sphingolipids and Glycerophospholipids"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPer Haberkant (Leiden Institute of Chemistry, The Netherlands)
"A Quantitative Map of Cellular Sphingolipid-Protein Complexes Revealed by Large-Scale Systematic Profiling"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnzymology and Regulation of Glycolipids and Sphingolipids
Discussion Leaders: Liana Silva (University of Lisbon, Portugal) and Teresa Dunn (Uniformed Services University of the Health Sciences, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJoost Holthuis (Osnabrück University, Germany)
"Molecular Dissection of Ceramide-Mediated Apoptosis Using Bifunctional Ceramides and Switchable Ceramide Transfer Proteins"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amAkio Kihara (Hokkaido University, Japan)
"Identification of Genes Involved in Epidermal Acylceramide Production"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amTomas Blom (University of Helsinki, Finland)
"LAPTM4B Interacts with Ceramide and Regulates Its Subcellular Distribution"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amToshihide Kobayashi (RIKEN, Japan)
"Cellular Localization of Sphingomyelin Clusters"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amAntonella Chiapparino (European Molecular Biology Laboratory, Germany)
"Systematic Isolation and Identification of In Vivo Formed Protein-Lipid Complexes in Eukaryotes"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmFlorian Froehlich (University of Osnabrück, Germany)
"Maintenance of Sphingolipid Homeostasis: A Crucial Role of Endosomal Vesicular Recycling"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmManuel Leonetti (University of California, San Francisco, USA)
"Systematic Approaches in Human Cells to Study Sphingolipid Regulation by ORM Proteins"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGlycolipid and Sphingolipid Metabolism and Organization
This session will cover lipid metabolism and traffic, but also effects of altered sphingolipid metabolism in mutants.
Discussion Leaders: Kentaro Hanada (National Institute of Infectious Diseases, Japan) and Antonella De Matteis (Telethon Institute of Genetics and Medicine, Italy)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:25 pmAnthony Futerman (Weizmann Institute of Science, Israel)
"Simple Sphingolipids in Complex Human Diseases"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmNils Faergeman (University of Southern Denmark, Denmark)
"Novel Mode of Activation of Ceramide Synthases by Acyl-CoA Binding Protein"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmPietro De Camilli (Yale University, USA)
"Membrane Contact Sites in the Regulation of Lipid Dynamics"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmMary Kraft (University of Illinois at Urbana-Champaign, USA)
"Sphingolipid Organization in the Plasma Membrane and Its Determinants"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGlycolipid and Sphingolipids in Infection, Inflammation and Autophagy
Discussion Leaders: Tilla Worgall (Columbia University, USA) and Ludger Johannes (Institut Curie, France)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amErich Gulbins (University of Duisburg-Essen, Germany)
"Sphingosine and Bacterial Infections"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amUrs Greber (University of Zurich, Switzerland)
"Lipid-Tuned Viral Infections"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amXueli Guan (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)
"Phosphosphingolipidomics of Trypanosomatids Reveals Lifecycle- and Taxonomic-Dependent Lipid Chemistry"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amMaurizio Del Poeta (Stony Brook University, USA)
"Fungal Lipids as Regulators of Fungal Pathogenesis and Host Immunity"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amGiuseppe Astarita (Waters Corporation, USA)
"Unbiased Lipidomics Reveals a Key Role for De Novo Ceramide Biosynthesis in Methamphetamine-Induced Systemic Inflammation"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmRachel Kraut (Biotechnology Center (BIOTEC), TU Dresden, Germany)
"The Drosophila Neurodegenerative Autophagy Mutant Blue Cheese Perturbs Sphingolipid Metabolism, Autophagic Clearance, and Stress/MAPK Signaling, and Is Rescued by Increased Ceramide Availability"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAshish Saroha (Weizmann Institute of Science, Israel)
"Short-Term Susceptibility to Lymphocytic Choriomeningitis Virus (LCMV) in Ceramide Synthase 2 (CerS2) Null Mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGlycolipid and Sphingolipid Tool Box
This session will cover lipidomics and novel technologies that will improve our understanding of the role of lipids.
Discussion Leaders: Alfred Merrill (Georgia Institute of Technology, USA) and Roger Sandhoff (German Cancer Research Center, Germany)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmCarsten Schultz (European Molecular Biology Laboratory, Heidelberg, Germany)
"Sphingosine as a Regulator of Lysosomal Ion Homeostasis and Autophagy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmXianlin Han (Sanford-Burnham Medical Research Insitute, USA)
"Shotgun Lipidomics and Its Application in Alzheimer's Research"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmBerend Snijder (Center for Molecular Medicine, Austria)
"Systems-Level Analyses to Reveal the Organizational Principles Underlying Lipid Abundance and Function"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmJonathan Weissman (Howard Hughes Medical Institute / University of California, San Francisco, USA)
"CRISPR Technology and Tagging Methods"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycolipid and Sphingolipid in Health and Disease
Discussion Leaders: James Shayman (University of Michigan, USA) and L. Ashley Cowart (Medical University of South Carolina, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amFrances Platt (University of Oxford, United Kingdom)
"Sphingolipid Storage Diseases: Unanticipated Links to Common Diseases"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amScott Summers (Baker IDI Heart and Diabetes Institute, Australia)
"Effect of Ceramide Depletion on Adipose Remodeling"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amWilliam Holland (University of Texas Southwestern Medical Center, USA)
"Interactions of Sphingolipids and Glucagon Critically Link Insulin Resistance to Hyperglycemia"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amAnnarita Di Lorenzo (Weill Cornell Medical College, USA)
"Nogo-B Regulates Sphingolipid Homeostasis to Impact Vascular Functions"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amStephanie Xie (Princess Margaret Cancer Centre, University Health Network, Canada)
"Differential Dependence on Sphingolipid Metabolism in the Normal and Leukemic Human Hematopoietic Hierarchy"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmJ. Thomas Hannich (Université de Genève, Switzerland)
"Deoxydihydroceramides and Anoxia Survival"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMariana Nikolova-Karakashian (University of Kentucky, USA)
"Chronic Elevation of Sphingomyelin Synthase 2 in Hepatic Cells Leads to Cell Senescence Associated with Mitochondrial Dysfunction and Neutral Fat Accumulation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSphingosine 1P Signaling in Health and Disease
Discussion Leaders: Richard Proia (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) and Nigel Pyne (University of Strathclyde, United Kingdom)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:25 pmSarah Spiegel (Virginia Commonwealth University, USA)
"The Role ORMDL3 in Ceramide Homeostasis and Asthma"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmJulie Saba (UCSF Benioff Children's Hospital Oakland, USA)
"An Update on Sphingosine Phosphate Lyase"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmTimothy Hla (Weill Cornell Medicine, USA)
"Sphingosine 1-Phosphate Signaling via Chaperones and Receptors"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmYoshikazu Uchida (University of California, San Francisco, USA)
"ER Stress Stimulates Production of Cathelicidin Antimicrobial Peptide by Forming a Stress Specific Novel Intracellular S1P Signaling Complex"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmGenetic Disorders of Glycolipids and Sphingolipids / Neurobiology
Discussion Leaders: Alessandro Prinetti (University of Milano, Italy) and Thierry Levade (INSERM UMR1037 Cancer Research Center of Toulouse, France)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amYoshio Hirabayashi (Brain Science Institute, RIKEN, Japan)
"Critical Roles of Lipid Modification with Glucose in Life: Unexpected Synthesis of Novel Glycolipids in the ER Membrane"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amGiovanni D'Angelo (Institute of Protein Biochemistry, National Research Council, Italy)
"A Molecular Circuit Controlling Glycosphingolipid Production and Neural Differentiation"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amVittorio Maglione (Neuromed Institute for Neurosciences, Italy)
"Sphingolipid Metabolism in Huntington's Disease: New Perspectives into Pathogenesis and Potential Treatment"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amShun-Ichi Nakamura (Kobe University, Japan)
"Essential Roles of Sphingosine 1-Phosphate Signaling in the Maturation of Exosomal Multivesicular Endosomes"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmThorsten Hornemann (University Hospital Zürich, Switzerland)
"Deoxysphingolipids"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTranslational Aspects of Glycolipid and Sphingolipid Biology
Discussion Leaders: Lina Obeid (Stony Brook University, USA) and Myles Cabot (Brody School of Medicine, East Carolina University, USA)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:25 pmRichard Kolesnick (Memorial Sloan-Kettering Cancer Center, USA)
"Ceramides and Radiation Therapy"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmLeah Siskind (University of Louisville, USA)
"Role of Glycosphingolipids in Mesangial Cell Hypertrophy in Diabetic Nephropathy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmIrina Petrache (National Jewish Health, USA)
"Metabolo-Genomic Sphingolipid Signatures in Lung Disease Phenotypes Induced by Chronic Cigarette Smoking"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmThomas Loughran (University of Virginia, USA)
"Targetting Acid Ceramidase in Acute Myeloid Leukemia"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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