Gordon Research Conferences
PI_Conferences PI_Conferences_Current
Conference Program
 
RNA Editing
Diversifying the Transcriptome: Consequences for Development and Disease
March 8-13, 2015
Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Related Meeting Information
The RNA Editing Gordon Research Conference was held in conjunction with the RNA Editing Gordon Research Seminar. Please refer to the RNA Editing GRS web page for more information.

The 2015 Gordon Research Conference on RNA Editing brings together researchers at the forefront of the field of editing and modification of nucleic acids. The impact of RNA and DNA editing and modification on biological systems is well-documented and progress in high-throughput nucleic acid sequencing techniques has clearly demonstrated that the information encoded in genomes is extensively altered at the level of gene expression. These changes impact processes as diverse as gene expression, protein synthesis, RNA splicing, somatic hypermutation, viral replication, organismal development, and immunoglobulin class switch recombination and are demonstrated to affect numerous human diseases, including cancer, metabolic disorders, pathogen recognition, immune system disorders, mitochondrial diseases, and viral and parasite pathogenesis. This biennial conference series has been held every other year since 1997, and is the only international meeting devoted to bringing together researchers working on the biogenesis, detection, and physiological consequences of normal and pathologic RNA-editing and modification events. The GRC provides a forum for researchers from diverse fields to interact extensively in an environment that promotes active discussion. Presentations from scientists at the frontiers of the field and at all stages of their careers will continue to enrich the highly collaborative nature of the RNA and DNA editing and modification fields and will excite new ideas and collaborations from among meeting participants leading to a broader understanding of these important processes in biology.

The 2015 GRC will include about 50 speakers representing all areas of RNA and DNA editing and modification systems, and a total of about 140 participants. The program will be organized to bring together experts and trainees working on different systems with common areas of interest, in the following broad areas: biogenesis and diversity of editing and modification; detection of editing and modification events, environmental adaptations and tuning genetic information; modification, editing and immunity; modification and editing-associated pathologies; regulation and quality control of editing and modification; transcriptomics and diagnostics; catalysis and target recognition by editing and modification enzymes; new horizons for editing and modification technology. A number of the speakers will be chosen from submitted abstracts, particularly from graduate students, postdoctoral fellows, junior faculty and underrepresented minorities, with a clear focus on the high scientific quality of a GRC. The program will also include four late afternoon poster sessions solely dedicated to encourage all participants to present results and engage in active discussions, and otherwise free afternoons to foster scientific interactions in a stimulating, but not competitive environment.


Contributors

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBiogenesis and Diversity of Editing and Modification
Discussion Leader: Maureen Hanson (Cornell University, USA)
7:40 pm - 8:00 pmReuben Harris (University of Minnesota, USA)
"DNA Deamination in Retrovirus and Cancer Mutagenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmAnita Hopper (The Ohio State University, USA)
"tRNA Processing and Modification in Yeast"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmRalph Bock (Max-Planck-Institute of Molecular Plant Physiology, Germany)
"Reconstituting Plastic RNA Editing at Heterologous Sites In Vivo"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmBrenda Bass (University of Utah, USA)
"Substrates and Functions of ADARs in C. elegans"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmToward Describing the Transcriptome
Discussion Leader: Heather Hundley (Indiana University, USA)
9:00 am - 9:20 amMark Helm (Johannes Gutenberg-Universitat Mainz, Germany)
"New Analytical Techniques for the Detection of RNA Modifications"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJin Billy Li (Stanford School of Medicine, USA)
"A-to-I Editing: From Identification to Regulation and Functions"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amMaureen Hanson (Cornell University, USA)
"New Insights into the Plant RNA Editosome"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amErez Levanon (BAR-ILAN University, Israel)
"Detection of A to I Editing in Development and Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGideon Rechavi (Tel Aviv University, Israel)
"The Role of m6A Methylation in Early Embryogenesis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmWendy Gilbert (Massachusetts Institute of Technology, USA)
"Regulated mRNA Modifications"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAyelet Lamm (Technion - Israel Institute of Technology, Israel)
"RNAi and RNA Editing: A Love or A Hate Story?"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmEnvironmental Adaptation and Tuning of Genetic Information
Discussion Leader: Valerie De Crecy-Lagard (University of Florida, USA)
6:00 pm - 6:20 pmRobert Reenan (Brown University, USA)
"Regulation of RNA Editing in Drosophila"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMizuki Takenaka (Ulm University, Germany)
"Different Protein Moieties Connect to Form Dynamic RNA Editosomes in Plant Organelles"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMarie Ohman (Stockholm University, Sweden)
"MicroRNA Editing as a Regulatory Event in Neurons"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmTsutomu Suzuki (University of Tokyo, Japan)
"A Single Acetylation of 18S rRNA Regulates Ribosome Biogenesis by Sensing Cellular Energy Status"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmMatus Valach (Universite de Montreal, Canada)
"Two Mechanistically Different Editing Pathways Act on Diplonemid Mitochondrial Transcripts"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEditing and Modification in Infection and Pathology
Discussion Leader: Nina Papavasiliou (Rockefeller University, USA)
9:00 am - 9:20 amRuslan Aphasizhev (Boston University, USA)
"Guide RNA Processing Pathway in Mitochondria of Trypanosomes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCatriona Jamieson (University of California, San Diego, USA)
"The Role of RNA Editing in Malignant Reprogramming"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAngela Gallo (Ospedale Pediatrico Bambino Gesù, Italy)
"RNA Editing Changes in Normal and Cancer Brain"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSebastian Leidel (Max Planck Institute for Molecular Biomedicine, Germany)
"Modified Nucleosides in the tRNA Anticodon Maintain Protein Solubility by Accelerating Decoding"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCharles Samuel (University of California, Santa Barbara, USA)
"Adenosine Deaminase Acting on RNA (ADAR1) and the Interferon Response: Lessons Gained from Measles Virus"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJorge Cruz-Reyes (Texas A&M University, USA)
"RNA Editing Regulation in Trypanosomes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmElisa Vilardo (Medical University of Vienna, Austria)
"Pathogenic Mutations in SDR5C1 Impair the tRNA Modification and Cleavage Activities of Human Mitochondrial RNase P"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmModification, Editing and Immunity
Discussion Leader: Mark Helm (Johannes Gutenberg-Universitat Mainz, Germany)
6:00 pm - 6:20 pmMary O'Connell (Masaryk University, CEITEC MU, Czech Republic)
"ADAR1: Finally an Answer to the Conundrum"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmHarold Smith (University of Rochester Medical Center, USA)
"The DNA Mutagenesis Editing Activity of APOBEC3G Is Regulated by RNA"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmNina Papavasiliou (Rockefeller University, USA)
"APOBEC1 Catalyzed RNA Editing Drives Heterogeneity in Immune Repertoires"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmDirk Iwata-Reuyl (Portland State University, USA)
"Amidinotransferase Diversity in the Modification of Archaeal tRNA"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLinda Chelico (University of Saskatchewan, Canada)
"Different Single-Stranded DNA Scanning Mechanisms Are Employed by Double Z-Domain and Single Z-Domain APOBEC3 Deoxycytidine Deaminases"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCatalysis and Target Recognition by Editing and Modification Enzymes
Discussion Leader: Mary O'Connell (Masaryk University, CEITEC MU, Czech Republic)
9:00 am - 9:20 amIan Small (University of Western Australia, Australia)
"RNA Sequence Recognition by Pentatricopeptide Repeat Editing Factors"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStewart Shuman (Memorial Sloan Kettering Cancer Center, USA)
"Structural Insights into RNA Repair"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amPeter Beal (University of California, Davis, USA)
"Recognition of Substrate RNA by the Catalytic Domain of Human ADAR2"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amYi-Tao Yu (University of Rochester Medical Center, USA)
"Targeted Pseudouridylation Affects RNA Functions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPeter Dedon (Massachusetts Institute of Technology, USA)
"Reprogramming of tRNA Modifications Interacts with a Genomic Code of Codons to Control Mycobacterial Dormancy"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAndrea Rentmeister (University of Muenster, Germany)
"Using RNA Modification Enzymes to Install Reporter Molecules"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmInna Afasizheva (Boston University, USA)
"RNA Binding and Core Complexes Constitute the U-Insertion/Deletion Editosome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRegulatory Networks and Quality Control
Discussion Leader: Jonatha Gott (Case Western Reserve University, USA)
6:00 pm - 6:20 pmKazuko Nishikura (The Wistar Institute, USA)
"Control of Two ADAR1 Functions in RNA Editing and RNA Silencing"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmEric Phizicky (University of Rochester School of Medicine, USA)
"tRNA Quality Control Mechanisms"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmPat Limbach (University of Cincinnati, USA)
"Exploring the Dynamics of tRNA Modification Patterns"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmHeather Hundley (Indiana University, USA)
"Regulation of A-to-I RNA Editing in Noncoding Regions of C. elegans mRNAs"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmMolecular Mechanisms and Macromolecular Machines
Discussion Leader: Reuben Harris (University of Minnesota, USA)
9:00 am - 9:20 amCelia Schiffer (University of Massachusetts Medical School, USA)
"Structural Interpretation of APOBEC3's"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amValerie De Crecy-Lagard (University of Florida, USA)
"Life Without Threonylcarbamoyladenosine, Consequences on Translation and Beyond"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amKenneth Stuart (Seattle Biomedical Research Institute, USA)
"Editing Site Selection and Differential Editing by Multiprotein Complexes in Trypanosomes"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amYa-Ming Hou (Thomas Jefferson University, USA)
"Preventing Ribosome Frameshifts by a tRNA Modification"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRonald Emeson (Vanderbilt University, USA)
"Functional Modulation of Secretion by CAPS1 RNA Editing"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmThorsten Stafforst (University of Tuebingen, Germany)
"Engineered Site-Directed RNA Editing in Transcript Repair"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRupert Fray (University of Nottingham, United Kingdom)
"Methylation of Eukaryote mRNA: Methylation Complex Components and Methylation Outcomes in the Model Plant Arabidopsis thaliana"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNew Horizons for the Transcriptome
Discussion Leader: Eric Phizicky (University of Rochester School of Medicine, USA)
6:00 pm - 6:20 pmJuan Alfonzo (The Ohio State University, USA)
"A Mitochondrial tRNA Modification and the Evolutionary History of Translational Accuracy in Eukarya"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmTom Meier (Albert Einstein College of Medicine, USA)
"Hunting for Pseudouridines"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmRonald Micura (Leopold Franzens University, Austria)
"Chemistry and Biophysics of mRNA Riboswitches"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmJoshua Rosenthal (University of Puerto Rico, USA)
"Regulation of Protein Function by Site-Directed RNA Editing"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2015 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter