Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Brain Matters: Membrane Transporters in Glia and Their Relationship to Disease
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Astrocytic Glutamate Transport, Mitochondria, and Calcium: What's a Little Energy Among Friends?"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"VGLUT3 in Parkinson's Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Endosomal pH as Therapeutic Target for Neurological Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Insights into Transporter Function: State-of-the Art Approaches
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Monitoring Conformational Dynamics upon Ligand Binding in Neurotransmitter:Sodium Symporters"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Single-Molecule Approaches to Monitor Conformational Dynamics in ABC Transporters"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Single Molecule Measurements Catch Transporters 'Taking a Break': On the Crucial Importance of Off-Cycle States for Function and Regulation"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Computer-Aided Drug Design Targeting Human Solute Carrier Transporters"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Presynaptic Gq-Coupled Receptor Activation Drives D2-Dependent, Biphasic Dopamine Transporter Surface Trafficking"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Quantum Dots Reveal Differential Membrane Compartmentalization of Dopamine Transporter and Dopamine D2 Autoreceptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Trafficking: Chaperoning Services
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Differential Regulation of Dopamine Transporter Activity in the SN and VTA"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Nucleoside Transporters: New Modalities of Regulation and Therapeutics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Cognate Ligand Chaperoning: A Novel Proteostatic Mechanism?"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Discovery of CFTR Modulators for the Treatment of Cystic Fibrosis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plasma Membrane as a Regulator of Transport
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"How Lipids Shape Proteins Oligomers: A Case Study Using Single Molecule Microscopy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reciprocal Regulation Between TRPV1 and PI3K: Role in Inflammatory Sensitization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Energetics of Protein-Lipid Interactions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Membrane Environment of DAT Plays a Critical Role in Promoting AMPH-Induced Efflux of DA Through DAT"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Phosphatidylinositol (4, 5)-Bisphosphate Coordinates Functional Interactions in the Dopamine Transporter to Promote Amphetamine Behaviors"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Evidence for Dopamine Transporter Dysfunction in Autism Spectrum Disorder"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Para-Substituted Methcathinones as Selective and Unselective Inhibitors of Human Dopamine and Serotonin Transporter"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Basis for Cooperativity in Dimeric SLC26 Transporters"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex as a Biological Variable in Transport Processes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Membrane Transporter Function in the Human Placenta and Their Role in Pregnancy Complications and Life Long Health"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Estrous Cycle-Dependent Alterations in Stimulant Actions at the Dopamine Transporter Underlie Enhanced Cocaine Reward in Females"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Sex Differences in Redox Environment and Neuronal Morphology Occur in Association with Enhancement of Excitability in System xc-Null Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Renal Transport Processes Regulated by Insulin and/or Insulin-Like-Growth Factors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters in the Brain and Their Role in Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Dissecting the Many Roles of the Dopamine Transporter in the Regulation of Psychostimulant Addiction"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"G Protein Modulation of the Dopamine Transporter and the Actions of Amphetamine"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Modeling Heritable Human Dopamine Transporter Dysfunction"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Defective Zinc Transport as an Etiology of Autism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cerebro Spinal Fluid Production: We Know So Much and Understand So Little; Cotransporters as the Missing Link?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Striatal Neurons Regulate VGLUT2 Expression and Topography in Dopamine Neurons"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporters in Disease: CFTR and ABC-Transporters
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Interactions and Cooperativity Between P-Glycoprotein Structural Domains Determined by Thermal Uncoupling and LRET"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Structural Mechanisms of KATP Channelopathies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"High-Speed Atomic Force Microscopy: Dynamics of Single Membrane Transporters and Channels in Membrane and Without Labels"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Biosynthetic Alterations and Correction in ABCC Proteins: Lessons Learned form CFTR and ABCC6"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Diabetes and Beyond: Transporters Are Key
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Glucose Transport and Metabolism in Obesity and Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Hidden Metabolic Costs of Synaptic Transporters: Staying Ready for Action Is Expensive"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Chloride Transporters in B-Cell Physiology"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Regulation of GLUT4 Dynamics by Ankyrins: Implications for Metabolic Flux and Diabetes"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Needle in a Haystack: Threading the Link Between SLC16A11 and Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Leptin Signals via a Novel Mechanism to Activate PKA for KATP Channel Trafficking to Suppress Insulin Secretion from Pancreatic B-Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Sweet Oscillations: Transporter Measurements In Vitro and In Vivo Using a Novel Genetically-Encoded Biosensor for Glucose"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Transporters and Channels
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 6:05 pm
"Genomewide and Evolutionary Studies Reveal Transporters as Determinants of Metabolic Disorders"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"4-Phenylbutyrate Corrects Folding-Deficient Creatine Transporter-1 Variants Associated with the Creatine Deficiency Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Structural Basis for Ibogaine Inhibition of hSERT Revealed by Single Particle Cryo-EM"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:15 pm
"Voltage Sensors and Membrane Capacitance"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure