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Glial Biology: Functional Interactions Among Glia & Neurons
Gordon Research Conference

Neuron-Glia Interactions in Health and Disease

Dates

March 5-10, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Beth A. Stevens

Vice Chair:
Dwight Bergles

Meeting Description

The goal of this meeting is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Far more active than once thought, glial cells are critical participants in every major aspect of brain development, function, and disease. The biology of astrocytes, microglia, and other glial cells in physiology and pathology will be emphasized. Leaders in the field will present cutting edge research and discuss critical gaps in our knowledge. The spirit of this conference will be constructive, collaborative and forward-looking, with an emphasis on emerging research, tools and technologies. In conjunction with the affiliated Gordon Research Seminar (GRS), trainees will have many opportunities to present their work, network, and share new ideas. The topics addressed in this meeting have direct relevance for human health, as they seek to clarify key mechanisms underlying nervous system injury and disease.

The program is divided into nine sessions covering the role of glia in brain development, plasticity, and homeostasis; modulation of synaptic function and dysfunction; metabolic control and neurovascular coupling; contribution to disease and repair; and emerging technologies for defining glial function. Poster sessions will permit all participants to contribute to these topics.

Related Meeting

This GRC was held in conjunction with the "Glial Biology: Functional Interactions Among Glia & Neurons" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmContribution of Glia to Brain Wiring
Discussion Leader: Richard Ransohoff (Biogen, USA)
7:40 pm - 8:00 pmDavid Lyons (University of Edinburgh, United Kingdom)
"How Does Neuronal Activity Regulate CNS Myelination?"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmStaci Bilbo (Harvard Medical School, USA)
"Sex Differences in Microglial Maturation in Mice and in Human Disease"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmEtienne Audinat (Paris Descartes University, France)
"Microglial Cells Control the Functional Maturation of Synapses in the Developing Somatosensory Cortex "
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmDorothy Schafer (University of Massachusetts Medical School, USA)
"Microglia: Dynamic Regulators of Brain Plasticity"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGlial Contributions to Synaptic Plasticity and Neuromodulation
Discussion Leader: Erik Ullian (University of California, San Franscisco, USA)
9:00 am - 9:20 amStephane Oliet (Neurocentre Magendie, INSERM U1215, France)
"IP3Rs in Astrocytes: Contribution to Ca2+ Signaling and Hippocampal Plasticity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSergey Kasparov (University of Bristol, United Kingdom)
"Glio-Protection and Neuroprotection via an Orphan G-Protein-Mediated Signalling Pathway"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAnna Molofsky (University of California, San Francisco, USA)
"Astrocyte-Microglia Crosstalk in Developmental Synapse Remodeling"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJaideep Bains (University of Calgary, Canada)
"Stress-Induced Structural and Functional Plasticity in Astrocytes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amNicola Allen (Salk Institute for Biological Studies, USA)
"Astrocyte Regulation of Neuronal Glutamate Receptors"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmBrian MacVicar (University of British Columbia, Canada)
"Metabolic Regulation of Microglia Immunosurveillance"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Michelle Monje (Stanford University, USA) and Alison Lloyd (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlia as Mediators of Circuit Dysfunction
Discussion Leader: Philip Haydon (Tufts University, USA)
7:30 pm - 7:50 pmMichael Salter (University of Toronto, Canada)
"Sex Differences in Microglia-Neuron Signaling in Chronic Pain"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEric Huang (University of California, San Francisco, USA)
"Progranulin and Microglia-Neuron Interactions in the Aging Brain"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSusan Campbell (Virginia Tech, USA)
"Glia Dysfunction in Epilepsy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSoyon Hong (Boston Children's Hospital / Harvard Medical School, USA)
"How Microglia Mediate Early Synapse Loss in Alzheimer's Disease"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShane Liddelow (Stanford University, USA)
"What Do Reactive Astrocytes Do?"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetabolic Control by Glia
Discussion Leader: Bruce Ransom (University of Washington School of Medicine, USA)
9:00 am - 9:20 amBruno Weber (University of Zurich, Switzerland)
"In Vivo Investigations of Neuron-Glia Interaction in Energy Metabolism"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKlaus-Armin Nave (Max Planck Institute for Experimental Medicine, Germany)
"Powering Axons: Novel Functions of Oligodendrocytes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRichard Ransohoff (Biogen, USA)
"What's Happening with Biogen's Microglia"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMark Verheijen (Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit Amsterdam, The Netherlands)
"Synapse Development Is Dependent on Lipids Derived from Astrocytes and Diet"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMichael Robinson (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Mitochondrial Dynamics and Ca Signals in Astrocyte Processes"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJoseph Dougherty (Washington University School of Medicine, USA)
"Localization and Activity Dependent Regulation of Translation in Astrocytes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMarko Kreft (University of Ljubljana, Slovenia)
"Insulin Modulates Cytoplasmic Glucose and Glycogen Levels in Astrocytes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlial Contributions to Neurovascular Coupling
Discussion Leader: Brian MacVicar (University of British Columbia, Canada)
7:30 pm - 7:50 pmGrant Gordon (University of Calgary, Canada)
"Behavioral State Dependence of Cortical Astrocyte Ca2+ Signals During Neurovascular Coupling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEric Newman (University of Minnesota, USA)
"Glial Cell Regulation of Blood Flow: Fact or Fantasy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSerge Charpak (Paris Descartes University, France)
"Glial and Neuronal Control of Brain Blood Flow"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmElizabeth Hillman (Columbia University, USA)
"The Role of the Vascular Endothelium in Neurovascular Coupling – A Unifying Model?"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructural and Functional Heterogeneity Among Glia
Discussion Leader: Helmut Kettenmann (Max Delbruck Center for Molecular Medicine, Germany)
9:00 am - 9:20 amFrank Kirchhoff (University of Saarland, Germany)
"Diversity of Signalling in Oligodendrocytes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amYe Zhang (University of California, Los Angeles, USA)
"What Do Human Astrocytes Do?"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPatrizia Casaccia (Icahn Medical School at Mount Sinai, USA)
"Role of Histone Methylation in Oligodendrocyte Function"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMario Capecchi (University of Utah, USA)
"Role of Hoxb8-Microglia on Neural Circuitry"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKeith Murai (McGill University, Canada)
"Creating Astrocyte Diversity in the Mature Brain: Implications for Circuit Function and Brain Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMarc Freeman (Vollum Institute, USA)
"CNS Glia in Neural Circuit Assembly and Function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmGlial Cell Development
Discussion Leader: Kelly Monk (Washington University School of Medicine, USA)
7:30 pm - 7:50 pmSonia Garel (Ecole Normale Superieure, France)
"Microglia in the Early Wiring of Cortical Circuits"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmXianhua Piao (Boston Children's Hospital, Harvard Medical School, USA)
"Microglia-Extracellular Matrix-Oligodendrocyte Cross-Talk in Myelin Development and Repair"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmCagla Eroglu (Duke University Medical Center, USA)
"How Do Synapses Control Astrocyte Development?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMaxwell Heiman (Harvard Medical School / Boston Children's Hospital, USA)
"Glial Development in C. elegans"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Technologies for Understanding Glial Cell Function
Discussion Leader: Dwight Bergles (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:20 amAxel Nimmerjahn (Salk Institute for Biological Studies, USA)
"Neuron-Astrocyte Communication in Spinal Cord of Behaving Mice"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSteve McCarroll (Harvard Medical School, USA)
"Diversity Among and Within Multiple Classes of Glia"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAnne Schaefer (Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, USA)
"Epigenetic Control of Microglia Specification"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amBaljit Khakh (University of California, Los Angeles, USA)
"Astrocyte Calcium Signaling in Neural Circuits Explored with a Novel Calcium Silencing Approach"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKo Matsui (Tohoku University, Japan)
"Optogenetic Control of Astrocytes and Mind"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAmit Agarwal (Johns Hopkins University, USA)
"New Conditional Mouse Lines for Studying Glial Cell Physiology"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGliogenesis in Health and Disease
Discussion Leader: Beth Stevens (Boston Children's Hospital, USA)
7:30 pm - 7:50 pmHui Zong (University of Virginia, USA)
"Homeostatic Interaction Among OPCs as the Basis of Cell Competition that Drives Gliomagenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichelle Monje (Stanford University, USA)
"Neuronal Activity Promotes Proliferation of Healthy and Malignant Glial Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAlison Lloyd (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
"Schwann Cell Orchestration of Nerve Regeneration"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmHarald Sontheimer (Virginia Tech, USA)
"Reactive Astrocytes as 'Drivers' of Epilepsy"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Neurological Disorders And Stroke of the National Institutes of Health under Award Number 1R13NS101905-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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