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Cell Biology of Megakaryocytes and Platelets
Gordon Research Conference

Fundamental Biology and Disorders of the Megakaryocyte Lineage: From Hematopoietic Stem Cell to Hemostasis

Dates

February 26 - March 3, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Benjamin T. Kile

Vice Chair:
Wolfgang Bergmeier

Meeting Description

The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier international scientific meeting focused on the biology of the megakaryocyte lineage, from HSCs through to platelets. Fusing the latest developments in fundamental science with high-impact translational research, this, the 7th biennial meeting, will provide a stimulating program featuring an international mix of established and up-and-coming researchers.

Sessions will cover a diverse range of topics, including megakaryocyte lineage development, progress in identifying the causes of congenital disorders of platelet number and function, myeloproliferative disease and acute megakaryoblastic leukemia, platelet signalling, the role of platelets in settings such as cancer and immunity, and new therapeutic approaches to diseases both of, and involving, the megakaryocyte lineage.

Known for its collegial and inclusive atmosphere, the meeting draws a mixture of scientists, clinicians and industry representatives. It provides the ideal setting for cross-fertilization of ideas, conceptual advances, and the promotion of collaborations.

This GRC is tied in with a two-day Gordon Research Seminar (GRS) for trainees interested in the field, giving them the opportunity to present their research, and gain insights from senior academic and industry investigators in this area. This will be enhanced by a panel discussion on developing a research career in academia and industry. Furthermore, abstracts submitted to the GRS by trainees will be scored by a panel, and the highest rated will be selected for oral presentation during the GRC.

Related Meeting

This GRC was held in conjunction with the "Cell Biology of Megakaryocytes and Platelets" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Fundamental Biology to Novel Therapies
Discussion Leader: Jack Levin (UCSF School of Medicine, USA)
7:40 pm - 8:20 pmAndrew Weyrich (University of Utah School of Medicine, USA)
"The Evolving Roles of Platelets in Health and Disease"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMartine Jandrot-Perrus (Laboratory for Vascular Translational Science (LVTS), Paris Diderot University, France)
"GPVI: From Accessory Physiological Role to Major Therapeutic Asset"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPlatelet Signaling: Lipids, Granules and Membranes
Discussion Leader: Elizabeth Gardiner (Australian National University, Australia)
9:00 am - 9:25 amJunling Liu (Shanghai Jiao Tong University School of Medicine, China)
"Activation of Platelet Function Through Adhesion G Protein-Coupled Receptors"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amLawrence Brass (University of Pennsylvania, USA)
"Putting It All Together: Integrating the Platelet Signaling Network and the Hemostatic Response to Injury"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Benjamin Tourdot (University of Michigan, USA)
"12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amCoffee Break
10:55 am - 11:20 amAlastair Poole (University of Bristol, United Kingdom)
"Platelet Ballooning: Transforming Cell Shape for Procoagulant Activity"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmJustin Hamilton (Monash University, Australia)
"Class II PI3Ks in Platelet Membrane Structure and Function"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Stephen Holly (University of North Carolina at Chapel Hill, USA)
"AADACL1 Regulates Platelet Granule Secretion and Thrombosis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Gardiner (Australian National University, Australia) and Kellie Machlus (Harvard Medical School, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmEmbryonic and Ontological Development of Megakaryocytes and Platelets
Discussion Leader: James Palis (University of Rochester Medical Center, USA)
6:00 pm - 6:25 pmSamir Taoudi (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Exploring the Mechanism of Platelet Formation During Prenatal Life"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmMartha Sola-Visner (Boston Children's Hospital, USA)
"Insights into the Transition from Neonatal to Adult Megakaryopoiesis"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmAna Cvejic (University of Cambridge, United Kingdom)
"Single Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Haematopoietic Cells"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Vanessa Scanlon (Yale University, USA)
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAchilles' Heels: Identifying the Causes of Congenital Platelet Disorders
Discussion Leader: Kathleen Freson (Katholieke Universiteit Leuven, Belgium)
9:00 am - 9:25 amPatrizia Noris (Fondazione IRCCS Policlinico San Matteo / University of Pavia, Italy)
"Inherited Thrombocytopenias: Bleeding and Much More"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amJorge Di Paola (University of Colorado, USA)
"ETV6-Related Thrombocytopenia: Lessons from Humans and Animal Models"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Mikhail Panteleev (Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Russia)
"Programmed Cell Death of Platelets and Megakaryocytes in Wiscott-Aldrich Syndrome"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amCoffee Break
10:55 am - 11:20 amNeil Morgan (University of Birmingham, United Kingdom)
"Finding Novel Genes for Inherited Bleeding Disorders with Platelet Dysfunction"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmNajet Debili (INSERM, France)
"Role of FLNA and DIAPH1 in Macrothrombocytopenia - From Functional Studies to Diagnosis or Vice-Versa?"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Walter Kahr (University of Toronto, Canada)
"Inherited Loss of the Arp2/3 Complex Component ARPC1B Results in Microthrombocytes and Predisposes to Inflammatory Disease"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBackbone of the Lineage: TPO and c-Mpl Signalling in Health and Disease
Discussion Leader: Nichola Cooper (Imperial College Healthcare, United Kingdom)
6:00 pm - 6:25 pmWarren Alexander (Walter and Eliza Hall Institute of Medical Research, Australia)
"Expression and Roles of the Mpl Receptor in Health and Disease"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmIan Hitchcock (University of York, United Kingdom)
"New Insights into Thrombopoietin Receptor Activation"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmJames Bussel (Weill Cornell Medicine, USA)
"Clinical Effects of TPO Agents Inform Disease Biology"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Herve Falet (Blood Research Institute, BloodCenter of Wisconsin, USA)
"Endocytosis of the Thrombopoietin Receptor Mpl Regulates both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMyeloproliferative Neoplasms and Acute Megakaryoblastic Leukemia
Discussion Leader: Warren Alexander (Walter and Eliza Hall Institute of Medical Research, Australia)
9:00 am - 9:25 amTanja Gruber (St. Jude Children's Research Hospital, USA)
"Mechanisms of Acute Megakaryoblastic Leukemia in Non-Down Syndrome Patients"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amThomas Mercher (Institut Gustave Roussy, France)
"ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Bethan Psaila (National Institutes of Health, USA / University of Oxford, United Kingdom)
"One Cell at a Time: A Single-Cell Approach to Exploring Normal and Malignant Megakaryopoiesis"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amCoffee Break
10:55 am - 11:20 amJohn Crispino (Northwestern University, USA)
"Aberrant Megakaryopoiesis in the Myeloproliferative Neoplasms"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmMarito Araki (Juntendo University Graduate School of Medicine, Japan)
"Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Qiang Wen (Northwestern University, USA)
"Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmForm and Function: Cytoskeletal Regulation in Megakaryocytes and Platelets
Discussion Leader: Antonija Begonja (University of Rijeka, Croatia)
6:00 pm - 6:25 pmMarkus Bender (University Hospital Wuerzburg, Germany)
"Role of Cytoskeleton-Regulatory Proteins in Platelet Production and Function"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmCatherine Leon (INSERM U949, EFS-Alsace, Université de Strasbourg, France)
"Actomyosin, Key Player at Multiple Steps in Platelet Biogenesis"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmSteve Thomas (University of Birmingham, United Kingdom)
"Platelet Actin Organisation – Peeking Beyond the Diffraction Limit"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Ejaife Agbani (University of Bristol, United Kingdom)
"Water Channel Aquaporin-1 Regulates Platelets' Procoagulant Response and In Vivo Thrombus Formation"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmPlatelets, Inflammation and Innate Immunity
Discussion Leader: Craig Jenne (University of Calgary, Canada)
9:00 am - 9:25 amJane Freedman (University of Massachusetts Medical School, USA)
"Platelets and Innate Immunity: From Mechanism to Populations"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amEric Boilard (CHU de Quebec, Universite Laval, Canada)
"Platelets and Platelet-Derived Microparticles in Antibody-Mediated Inflammatory Responses"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: June Li (University of Toronto, Canada)
"Platelet Desialylation: Novel Mechanism of Immune Tolerance"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amCoffee Break
10:55 am - 11:20 amMarieke Essers (Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Germany)
"Inflammation-Induced Emergency Hematopoiesis"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmAdam Cunningham (University of Birmingham, United Kingdom)
"The Balance Between Inflammation and Thrombosis During Gram-Negative Infection"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Pierre Cunin (Brigham and Women's Hospital, USA)
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTumour Cells and Platelets: Une Affaire Compliquée
Discussion Leader: Emma Josefsson (The Walter and Eliza Hall Institute of Medical Research, Australia)
6:00 pm - 6:25 pmMyriam Labelle (St. Jude Children's Research Hospital, USA)
"Signaling Roles of Platelets During Metastatic Seeding"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmAnil Sood (University of Texas MD Anderson Cancer Center, USA)
"Emerging Role of Platelets in Adaptive Changes to Anti-Angiogenesis Therapy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmElisabeth Battinelli (Brigham and Women's Hospital / Harvard Medical School, USA)
"Platelets and Tumor Cells: Breaking the Cycle"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Amanda Unsworth (University of Reading, United Kingdom)
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL135868-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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