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Amygdala Function in Emotion, Cognition & Disease
Gordon Research Conference

Emerging Perspectives on the Role of the Amygdala in Regulating Higher-Order Behavior and Neuropsychiatric Disease

Dates

August 6-11, 2017

Location

Stonehill College
Easton, MA Site Information

Organizers

Chair:
Andrew Holmes

Vice Chair:
Kay M. Tye

Application Deadline

This meeting is currently oversubscribed (full). You may still submit an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The amygdala is a brain structure known to play a pivotal role in emotion, and has become the focus of interest to neuroscientists and the lay public in recent years. Rapid progress has been made in elucidating the cellular and molecular plasticity mechanisms involved in the acquisition and expression of conditioned fear, largely using rodent models. However, there has been growing appreciation of the critical role of the amygdala in reward processing and other brain functions that become abnormal in addiction. There is marked overlap in the amygdala plasticity mechanisms found to be maladaptive in models of, for example, drug abuse and anxiety. Added to this is a compelling body of clinical evidence implicating the amygdala in disorders ranging from PTSD, autism to substance abuse and other addictions. The meeting will focus on research investigating the role of the amygdala in both normal and pathological processes spanning multiple levels of neural organization - from molecular and cellular mechanisms at one end, to circuits, networks, behavior and disease at the other. An overarching rationale for this meeting is to bring together amygdala scientists and scientist-clinicians with differing scientific questions and approaches that have advanced our understanding of the biological basis of behavior and illness. Meaningful interactions between scientists with different questions, different techniques, and different levels of analysis, with clinician-scientists will serve as an impetus for new collaborations that may translate basic discovery research findings. The meeting will reflect on ongoing shift in psychiatry towards framing the study of mental illness in terms of aberrant neural circuit functions. The amygdala is recognized as a central node within brain systems subserving an array of higher-order behaviors that are disturbed in various mental disorders. This meeting is expected to continue to be an exemplar for brain and psychiatric research over the coming years.

Related Meeting

This GRC will be held in conjunction with the "Amygdala Function in Emotion, Cognition & Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Amygdala in Brain Function and Psychiatric Disease: What Do We Know and Where Are We Going?
Discussion Leader: Kerry Ressler (McLean Hospital, Harvard Medical School, USA)
7:40 pm - 8:00 pmAndreas Luthi (Friedrich Miescher Institute, Switzerland)
"Neuronal Circuit Mechanisms for Associative Learning"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmCatherine Dulac (Harvard University / Howard Hughes Medical Institute, USA)
"Neural Architecture of Social Behavior Circuits"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmGeorge Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"The Role of the Extended Amygdala in the Dark Side of Addiction"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Networked Amygdala: The Amygdala's Place in Systems-Wide Brain Networks
Discussion Leader: Denis Pare (Rutgers University, USA)
9:00 am - 9:20 amStephen Maren (Texas A&M University, USA)
"Hippocampal-Prefrontal Circuit Mediating Relapse of Extinguished Fear"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCristina Alberini (New York University, USA)
"Molecular Mechanisms of the Hippocampal-Amygdala-Medial Prefrontal Cortex System in Inhibitory Avoidance Memory"
9:50 am - 10:00 amDiscussion
10:00 am - 10:35 amCoffee Break
10:35 am - 10:55 amMark Schnitzer (Stanford University, USA)
"Neural Ensemble Dynamics Underlying a Long-Term Associative Fear Memory"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amJoshua Gordon (National Institute of Mental Health, NIH, USA)
"Regulation of Fear Responses by a Prefrontal-Amygdala Circuit"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amJoshua Johansen (RIKEN Brain Science Institute, Japan)
"Distinct Noradrenaline Cell Populations Coordinate Emotional and Flexible Learning States"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmMark Ansorge (Columbia University, USA)
"Serotonin Modulates Maturation of Afferent Projections to the Amygdala"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sheena Josselyn (Hospital for Sick Children / University of Toronto, Canada) and Jane Taylor (Yale University School of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Engrammatic Amygdala: Neuronal Codes and Ensembles Underlying Behavior
Discussion Leader: Ron Stoop (University of Lausanne, Switzerland)
7:30 pm - 7:50 pmSheena Josselyn (Hospital for Sick Children / University of Toronto, Canada)
"Making Memories"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPankaj Sah (Queensland Brain Institute, University of Queensland, Australia)
"Coding of Cued Fear by Neural Ensembles in the Lateral Amygdala"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRony Paz (Weizmann Institute of Science, Israel)
"Coding with Temporal Sequences in the Primate Amygdala"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmCyril Herry (Neurocentre Magendie, INSERM U862, France)
"Cooperation Among Prefrontal and Amygdala Inputs to the Periaqueductal Gray to Regulate Fear Behavior"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Rewarded Amygdala: Amygdala Control of Positive Valence in Healthy and Drug-Exposed Brains
Discussion Leader: Thomas Kash (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amBernard Balleine (University of New South Wales, Australia)
"Amygdala-Striatal Interactions in Predicted Value and Choice"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAlicia Izquierdo (University of California, Los Angeles, USA)
"Basolateral Amygdala and Orbitofrontal Cortex in Expected and Unexpected Changes in Outcome Value"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amPeter Rudebeck (Icahn School of Medicine at Mount Sinai, USA)
"Cingulate-Amygdala-Striatal Circuits in Anticipation and Receipt of Reward"
10:15 am - 10:25 amDiscussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:20 amDaniel Salzman (Columbia University, USA)
"Shared Neural Coding for Social Hierarchy and Reward in Primate Amygdala"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMarkus Heilig (Linkoping University, Sweden)
"An Amygdala-Mediated Molecular Mechanism for Choosing Alcohol over Natural Rewards"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmKate Wassum (University of California, Los Angeles, USA)
"Amygdala-Cortical Circuits in Reward Expectation and Valuation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Developing Amygdala: Dynamic Regulation of Behavior over Development
Discussion Leader: Katalin Gothard (University of Arizona, USA)
7:30 pm - 7:50 pmNim Tottenham (Columbia University, USA)
"Human Amygdala Functional Development and Early Environmental Influences"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmCatherine Hartley (New York University, USA)
"Dynamic Changes in Learning Underlying the Development of Behavioral Control"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRegina Sullivan (Nathan S. Kline Institute / NYU Langone Medical Center, USA)
"Transitions in Maternal Regulation of the Infant Amygdala"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRick Richardson (University of New South Wales, Australia)
"Accelerated Maturation of Neural Circuitry Underlying Memory Expression: Effects of Probiotics"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Micro-Circuitry of the Amygdala: Intrinsic Circuits and Cell Populations Mediating Amygdala Functions
Discussion Leader: Vadim Bolshakov (Harvard Medical School, USA)
9:00 am - 9:20 amMarie Monfils (University of Texas at Austin, USA)
"Social Transmission of Fear in Rats: Fear Conditioning by Proxy"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amAlexei Morozov (Virginia Tech, USA)
"Metaplasticity of the Prefrontal-Amygdala Pathway as a Two-Hit Mechanism of Pathological Fear"
9:55 am - 10:10 amDiscussion
10:10 am - 10:25 amRebecca Shansky (Northeastern University, USA)
"Resting State Functional Connectivity in the Rodent Amygdala: A Predictor of Divergent Behavioral Phenotypes?"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amJane Taylor (Yale University School of Medicine, USA)
"Amygdalar Targets of Memory Reconsolidation Processes that Reduce Cue-Induced Drug-Seeking Behavior"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amAnna Beyeler (University of Bordeaux, France)
"Functional and Anatomical Diversity in the Basolateral Amygdala"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmIngrid Ehrlich (University of Tuebingen, Germany)
"Amygdala Intercalated Cell Circuits and Their Role in Fear"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmThe Stressed Amygdala: Amygdala Responses and Regulation of Stressful Experience
Discussion Leader: Matthew Hill (Hotchkiss Brain Institute, Canada)
7:30 pm - 7:50 pmMichael Fanselow (University of California, Los Angeles, USA)
"Neural Mechanisms of Induction and Expression of Stress-Enhanced Fear Learning, an Animal Model of PTSD"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAlon Chen (Max-Planck-Institut für Psychiatrie, Germany)
"The Role of the Medial Amygdala in Regulating Socio-Emotional Balance"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSachin Patel (Vanderbilt University, USA)
"Stress Modulation of Amygdala Endocannabinoid Signaling"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShona Chattarji (National Centre for Biological Sciences (NCBS), India)
"Trumping Fear: What Goes up Must Come Down"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Fearful Amygdala: Threat Predictability, Flexibility, Discrimination and Inhibition
Discussion Leader: Haruhiko Bito (University of Tokyo, Japan)
9:00 am - 9:20 amChris Pape (University of Muenster, Germany)
"Synaptic Circuits of the Extended Amygdala Impacting Responses to Predictable and Unpredictable Threat"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLarry Zweifel (University of Washington, USA)
"Dopamine Encodes Uncertainty in Fear Generalization"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amDaniela Schiller (Icahn School of Medicine at Mount Sinai, USA)
"Flexibility of Threat Learning"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amGregory Quirk (University of Puerto Rico, Puerto Rico)
"Avoiding Danger at All Costs"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amRoger Clem (Icahn School of Medicine at Mount Sinai, USA)
"Inhibitory Neuronal Substrates of Threat Learning"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmMario Penzo (National Institute of Mental Health, NIH, USA)
"Inhibitory Control of Aversive Memory Formation"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmLeon Reijmers (Tufts University, USA)
"Cellular and Oscillatory Substrates of Fear Extinction Learning"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Dark Side of the Amygdala: The Amygdala's Role in Addiction, Aggression and Defense
Discussion Leader: Stan Floresco (University of British Columbia, Canada)
7:30 pm - 7:50 pmYavin Shaham (Intramural Research Program, National Institute on Drug Abuse, NIH, USA)
"Role of Central Amygdala and Anterior Insula in Relapse After Voluntary Abstinence"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNicholas Gilpin (LSU Health Sciences Center New Orleans, USA)
"Central Amygdala Regulation of Alcohol Withdrawal Hyperalgesia"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmIvan de Araujo (The John B. Pierce Laboratory / Yale University, USA)
"Central Amygdala and the Motor Circuits Controlling Hunting and Feeding"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmBo Li (Cold Spring Harbor Laboratory, USA)
"The Central Amygdala Circuits in Learning and Expression of Defensive Responses"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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