Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Intracellular Communication via ROS: Insights into Mitochondria
Discussion Leader: Albert Van Der Vliet (University of Vermont, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:25 pm
Alicia Kowaltowski (Universidade de Sao Paulo, Brazil)
"Mitochondria, Dietary Interventions and Oxidants"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Fabio Di Lisa (University of Padova, Italy)
"Sources and Targets of Mitochondrial ROS Formation in Cardiac Pathophysiology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Douglas Thomas (University of Illinois at Chicago, USA)
"Epigenetics: The Third Pillar of Nitric Oxide Signaling in Cancer"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
NOX Back to Basics: Bridging Knowledge for the Future
Discussion Leader: Robert Clark (University of Texas Health Science Center at San Antonio, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Susan Smith (Kennesaw State University, USA)
"NOX Structure from Models to Crystals and Back"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Hideki Sumimoto (Kyushu University, Japan)
"Localization, Regulation and Function of NOX Family Oxidases"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Edgar Pick (Tel Aviv University, Israel)
"The N-Terminal SH3 Domain of p67-Phox: An Orphan Region in Search of a Ligand"
10:30 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Introduction by Discussion Leader
11:15 am - 11:30 am
Vincent Jaquet (University of Geneva, Switzerland)
"How to Measure NOX Activity and Validate NOX Inhibitors"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Katrin Schröder (Goethe University Frankfurt, Germany)
"Advantages and Challenges of Membrane Assay Systems to Measure ROS"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Becky Diebold (Emory University, USA)
"Detecting NADPH Oxidases by PCR and Western Blots: Not So Simple"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
From Structural Mechanisms to NOX Drug Development
Discussion Leader: Susan Smith (Kennesaw State University, USA)
6:00 pm - 6:25 pm
Andrea Mattevi (University of Pavia, Italy)
"Looking at the Three-Dimensional Structure of NOX"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Marie Erard (University of Paris-Saclay, UMR 8000, CNRS, France)
"The Cytosolic Complex of the Phagocyte NADPH Oxidase: From Quantitative Live Cell Imaging to 3D Model"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Franck Fieschi (Université Grenoble Alpes, France)
"NOX-Related Membrane Proteins and the Prokaryotic World"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
Philippe Wiesel (Genkyotex SA, Switzerland)
"Targeting Inflammatory Pain and Angiogenesis with the Selective NOX1 Inhibitor GKT771"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
ROS Signaling and Networking
Discussion Leader: Miklós Geiszt (Semmelweis University, Hungary)
9:00 am - 9:25 am
Harald Schmidt (Maastricht University, The Netherlands)
"Systems Medicine of ROS-Related Diseases"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Melissa Kemp (Georgia Institute of Technology / Emory University, USA)
"NOX Activity in Systems Biology Modeling of Redox Signaling and Metabolism"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Valentin Cracan (Harvard Medical School / Massachusetts General Hospital, USA)
"Genetically Encoded Tools for Compartment-Specific Manipulation of NAD+/NADH and NADP+/NADPH Ratios in Living Cells"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Fabian Hahner (Universitätsklinikum Frankfurt, Germany)
"The NADPH Oxidase NOX4 Promotes Endothelial Differentiation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Lucia Lopes (University of Sao Paulo, Brazil)
"Redox Activation of NOX1 Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yukio Nishimoto (Chubu University, Japan)
"Constitutively Active NADPH Oxidase 4 Functions as a Hydrogen Peroxide Sensor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"Dissecting the Role of the NADPH Oxidase NOX4 During Liver Regeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Hallmarks of NOX Function - Immunity and Inflammation
Discussion Leader: Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Switzerland)
6:00 pm - 6:25 pm
Yun Soo Bae (Ewha Womans University, South Korea)
"Regulation of NOX Activity by TLR in Inflammation"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Rikard Holmdahl (Karolinska Institutet, Sweden)
"ROS Regulation of Autoimmune Disease"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Harry Malech (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Progress Towards CRISPR Mediated Gene Editing Correction of Chronic Granulomatous Disease in Patient CD34+ Hematopoietic Stem Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Marie Jose Stasia (Université Grenoble Alpes, France)
"Downregulation of NOX2 Activity in Phagocytes Mediated by ATM Kinase Dependent Phosphorylation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
ROS as Key Player in Interkingdom Crosstalk at Barriers
Discussion Leader: Marie Jose Stasia (Université Grenoble Alpes, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Gerard Clarke (University College Cork, Ireland)
"Crosstalk in the Microbiome-Gut-Brain Axis and Host Behavior: Focus on Microbial Regulation of Tryptophan Metabolism"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Helmut Grasberger (University of Michigan, USA)
"DUOX in Gut Health and Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Kim Orth (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, USA)
"Vibrio : Subverting ROS for Survival and Proliferation in a Host Cell"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Silvia Cellone Trevelin (King's College London, United Kingdom)
"Regulatory T Cells Deficient in NOX2 Limit Angiotensin II-Induced Hypertension and Cardiovascular Remodeling"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ashish Singh (University College Dublin, Ireland)
"Hydrogen Peroxide Production by Lactobacilli Prevents Colitis and Intestinal Infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sjoerd van der Post (Washington University in St. Louis, USA)
"NOX1-Dependent Redox Signaling Mediates Colonic Stem Cell Proliferation via EGFR Potentiated by Microbial Components"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Corinne Dupuy (Institut Gustave Roussy / CNRS, France)
"Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2 O2 Production Defect"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Redox Signals in Cancer - From NOS to NOX
Discussion Leader: David Lambeth (Emory University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Memo1, a Redox Protein with Roles in Aging and in Cancer"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
James Doroshow (National Cancer Institute, NIH, USA)
"NADPH Oxidases, Pro-Inflammatory Cytokines, and Inflammation-Related Cancers"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Thomas Leto (National Institute of Allergy and Infectious Diseases, NIH, USA)
"NOX4 Involvement in Cancer Progression"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
NOXes in Disease Pathophysiology
Discussion Leader: Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
9:00 am - 9:25 am
David Brenner (University of California, San Diego, USA)
"The Role of NOXs in Liver Fibrosis and Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Louise Hecker (University of Arizona, USA)
"Pre-Clinical Development of Novel NOX4 Inhibitors for Targeting Age-Associated Pathological Fibrosis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Karl-Heinz Krause (University of Geneva, Switzerland)
"NOX Enzymes in Inner Ear Pathology"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Simone Di Giovanni (Imperial College London, United Kingdom)
"NOX2 Signaling Pathways Underpin Injury and Environmentally Driven Axonal Regeneration Following Nerve and Spinal Injuries"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ildiko Szanto (Geneva University Hospitals, Switzerland)
"Beta-Cell Specific Overexpression of the NADPH Oxidase 5 (NOX5) Deteriorates Islet Cell Function in High-Fat Diet Exposed Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Natalie Torok (University of California, Davis, USA)
"NOX2 Activation by p52Shc Leads to Accelerated Liver Fibrosis in Aging Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Carmen Veith (Maastricht University, The Netherlands)
"Profibrotic Signaling by TGF-b1 Involves NADPH Oxidase 4-Dependent Activation of the Tyrosine Kinase Fyn"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
NOX-Mediated ROS Signaling in Metabolism and Cardiovascular Disease
Discussion Leader: Rhian Touyz (University of Glasgow, United Kingdom)
6:00 pm - 6:25 pm
Jun Sadoshima (Rutgers New Jersey Medical School, USA)
"The Cell Type-Specific Function of NOX4 During Heart Failure"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Ajay Shah (King's College London, United Kingdom)
"NOX4 and Metabolic Reprogramming"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Lev Becker (University of Chicago, USA)
"NOX2 Signaling in Macrophages Supports Detrimental and Beneficial Functions in Obesity and Type 2 Diabetes"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure