Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Autophagy Breakthrough
Discussion Leaders: Manuela Antonioli (Lazzaro Spallanzani National Institute for Infectious Diseases, Italy) and Jeff Willy (Eli Lilly and Company, USA)
3:15 pm - 3:45 pm
Noboru Mizushima (The University of Tokyo, Japan)
"Autophagy: From Yeast to Nobel Prize"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Molecular Mechanisms Behind Autophagic Response
Discussion Leaders: Francesca Nazio (Bambino Gesù Children's Hospital, Italy) and Mathieu Bourdenx (Albert Einstein College of Medicine, USA)
5:30 pm - 5:45 pm
Noopur Khobrekar (Columbia University Medical Center, USA)
"RILP Is an mTOR-Regulated Dynein Motor Adaptor Protein Required for Mammalian Autophagosome Assembly and Transport"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Raffaela Torggler (Max F. Perutz Laboratories / University of Vienna, Austria)
"Two Independent Pathways Within Selective Autophagy Converge to Activate Atg1 Kinase at the Vacuole"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Thomas Mercer (The Francis Crick Institute, United Kingdom)
"Unraveling the ULK Phosphoproteome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Alexander Agrotis (University College London, United Kingdom)
"Redundant Human ATG4 Proteins Required for LC3/GABARAP Priming but Not Delipidation During Autophagy"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Andrea Stavoe (University of Pennsylvania, USA)
"Expression of WIPI2B Counteracts Age-Related Decline in Autophagosome Biogenesis in Neurons"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
John Steven Ekman (Washington University in St. Louis School of Medicine, USA)
"Atg14 Protects the Intestinal Epithelium from TNF-Induced Apoptosis"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Autophagy in Physiology and Pathophysiology
Discussion Leaders: Patrice Petit (CNRS FR3636, Paris Descartes University, France) and Sandra Soukup (VIB, KU Leuven, Belgium)
9:00 am - 9:15 am
Stephanie Erjavec (Columbia University, USA)
" Role of the Autophagic Protein, STX17, in Melanogenesis and Alopecia Areata"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Gianna Fote (University of California, Irvine, USA)
"IKKB Slows Huntington's Disease Progression in R6/1 Mice"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Martina Di Rienzo (Lazzaro Spallanzani National Institute for Infectious Diseases, Italy)
"TRIM32 Regulates ULK1 Ubiquitination and Autophagy Induction During Muscle Atrophy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Davor Ivankovic (University College London, United Kingdom)
"Defective Axonal Autophagosome Maturation in AP-4 Deficiency Syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Rachel Ulferts (University of Cambridge, United Kingdom)
"Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but Has a Distinct Molecular Basis"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Veronik Lachance (Icahn School of Medicine at Mount Sinai, USA)
"Understanding the Potential Role for Dysregulation of Autophagy Complexes, ULK1 and PI3KC3, in Predisposing Pathogenesis of Alzheimer's Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career: European and American Experiences
Discussion Leader: Bita Nakhai (National Institute on Aging, NIH, USA)
1:30 pm - 2:30 pm
Panel Discussion
European, American and Pharmaceutical Careers
Anna Katharina Simon (The Kennedy Institute of Rheumatology, University of Oxford, United Kingdom)
Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
Frank Dorsey (Eli Lilly and Company, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes