Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Structure and Regulation of NADPH Oxidase Enzymes
Discussion Leader: David Heppner (Dana-Farber Cancer Institute, USA)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:35 pm
Marta Ceccon (Scuola Universitaria Superiore IUSS Pavia, Italy)
"New Approaches for the Biochemical and Structural Characterization of NOX5"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Dina Vara (University of Exeter, United Kingdom)
"A Novel Combinatorial Technique to Detect Superoxide Anions Elucidates NADPH Oxidase-Dependent Regulation of Human Platelets"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Biological Roles of NADPH Oxidases and Redox Signaling: From the Single Cell to the Complex Organism
Discussion Leader: Aikaterini Anagnostopoulou (University of Glasgow, United Kingdom)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:55 pm
Aicha Bouraoui (Laboratoire de Chimie Physique, France)
"Poldip2 Effect on Nox2 and Nox4 Activity"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Joao Wosniak Junior (University of Sao Paulo, Brazil)
"Protein Disulfide Isomerase-A1 Coordinates NADPH Oxidase Subtype-Dependent Mechanisms Promoting Vascular Smooth Muscle Phenotypic Switches"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Augusto Montezano (Institute of Cardiovascular and Medical Science, University of Glasgow, United Kingdom)
"NOX5 Regulation of Vascular Contraction Involves Oxidation of ER Calcium Channels and Calreticulin"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
Carmen Veith (Maastricht University, The Netherlands)
"Profibrotic Signaling by TGF-β1 Involves NADPH Oxidase 4-Dependent Activation of the Tyrosine Kinase Fyn"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
NADPH Oxidases in Health and Disease
Discussion Leader: Carmen Veith (Maastricht University, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Irene Peñuelas-Haro (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Spain)
"New Insights into the Molecular Mechanisms Regulated by the NADPH Oxidase NOX4 in Hepatocellular Carcinoma"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sjoerd van der Post (Washington University in St. Louis, USA)
"NOX1 Dependent Redox Signaling Mediates Colonic Stem Cell Proliferation via EGFR Potentiated by Microbial Components"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Livia Camargo (University of Glasgow, United Kingdom)
"Interplay Between Nox-Regulated Oxidative Stress and ER Stress Response in Experimental Hypertension"
10:15 am - 10:20 am
Discussion
10:20 am - 10:40 am
Yao Li (University of Pittsburgh, USA)
"NOX2-Selective Small Molecule Inhibitors Ameliorate TNFa-Stimulated Endothelial Cell Activation and Dysfunction"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Your Scientific Career Path
Discussion Leaders: Ulla Knaus (Conway Institute, University College Dublin, Ireland) and Albert Van Der Vliet (University of Vermont, USA)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Your Scientific Career Path
Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Switzerland)
Patrick Pagano (University of Pittsburgh, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes