The Gordon Research Seminar on Thiol-Based Redox Regulation and Signaling is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
This Gordon Seminar will focus on redox modification of protein thiols and the role they play in a broad range of cellular processes. Because altered thiol-based signaling is central to aging and aging-associated diseases, and modified redox homeostasis defines age-related dysfunction, there will be a particular focus on mechanisms that underlie this relationship.In particular, emphasis will be on the role of thiol-based redox regulation in cancer, inflammation, metabolic disorders, and in the context of environmental stress. Discussion topics will range from the chemical basis for reactive oxygen species and reactive nitrogen species and thiol-based interactions, to the study of how redox modifications integrate into cellular signaling and physiology, as well as on the development of novel tools to study thiol modifications and thiol-dependent processes.
This GRS was held in conjunction with the "Thiol-Based Redox Regulation & Signaling" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Redox Signaling in Cancer and Metabolic Disease|
|Discussion Leader: Nina Kaludercic (National Research Council, Italy)|
|3:45 pm - 4:00 pm||Leticia Roma (German Cancer Research Center, Germany)|
"In Vivo 'Redox Maps' in Diabetic Mouse Models"
|4:00 pm - 4:05 pm||Discussion|
|4:05 pm - 4:25 pm||Isaac Harris (Harvard Medical School, USA)|
"Functional Profiling of Antioxidant Liabilities in Cancer"
|4:25 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Spatiotemporal Dynamics of Redox Signalling|
|Discussion Leader: Bruno Manta (Brigham and Women's Hospital / Harvard Medical School, USA)|
|7:30 pm - 7:45 pm||Crystal Conaway (University of South Carolina, USA)|
"Compartmentalization of Mitochondrial Glutathione in Saccharomyces cerevisiae Under Severe Redox Stress"
|7:45 pm - 7:50 pm||Discussion|
|7:50 pm - 8:10 pm||Sasha De Henau (University Medical Center Utrecht, The Netherlands)|
"Cellular Polarization as a Model to Study Spatiotemporal Redox Regulation"
|8:10 pm - 8:15 pm||Discussion|
|8:15 pm - 8:35 pm||Daria Ezerina (German Cancer Research Centre (DKFZ), Germany)|
"Cytoprotective Effects of NAC Are Mediated by H2S"
|8:35 pm - 8:40 pm||Discussion|
|8:40 pm - 9:00 pm||Loes van Dam (University Medical Center Utrecht, The Netherlands)|
"The Peroxiredoxin Redox-Relay in Cellular Redox Signal Specificity"
|9:00 pm - 9:05 pm||Discussion|
|9:05 pm - 9:25 pm||Evanna Mills (Trinity College, Dublin, Ireland)|
"Repurposing Mitochondria from ATP Production to ROS Generation via Reverse Electron Transport Induces a Pro-Inflammatory Phenotype in Macrophages"
|9:25 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Novel Methods for Assessing Thiol Redox Status|
|Discussion Leader: Jesalyn Bolduc (Wake Forest School of Medicine, USA)|
|9:00 am - 9:15 am||Kyle Cole (Boston College, USA)|
"Synthesis and Characterization of Triazine-Based Covalent Inhibitors of Protein Disulfide Isomerase A1"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:40 am||Elizabeth Hinchy (MRC Mitochondrial Biology Unit, United Kingdom)|
"Utilising Click PEGylation to Assess Protein Thiol Redox States by Cysteine Trapping Followed by Immunoblotting"
|9:40 am - 9:45 am||Discussion|
|9:45 am - 10:05 am||Yu-Hsuan Kuo (University of Michigan, Ann Arbor, USA)|
"Chemoselective Profiling of Cysteine Sulfinic Acids in Complex Proteomes"
|10:05 am - 10:10 am||Discussion|
|10:10 am - 10:30 am||Jeffrey Lawson (Wake Forest School of Medicine, USA)|
"A Structural and Biochemical Analysis of Human Peroxiredoxin-3: A Unique Member of the Prx Family"
|10:30 am - 10:35 am||Discussion|
|10:35 am - 10:55 am||Lia Randall (Universidad de la República, Uruguay)|
"Structural and Functional Characterization of the Nitrated Form of Peroxiredoxin 2"
|10:55 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Navigating Your Scientific Career Path|
|Discussion Leaders: Edward Chouchani (Dana-Farber Cancer Institute, USA) and Jade Mims (Wake Forest School of Medicine, USA)|
|1:30 pm - 2:30 pm||Panel Discussion|
|"Navigating Your Scientific Career Path"|
- Joris Messens (VIB, Vrije Universiteit Brussel, Belgium)
- Melissa Kemp (Georgia Institute of Technology, USA)
- Eranthie Weerapana (Boston College, USA)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Funding for this conference was made possible, in part by 1R13AG053038-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.