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Synthetic Biology
Gordon Research Conference

Advancing Biosystems Design

Dates

June 28 - July 3, 2015

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Sven Panke

Vice Chair:
Farren Isaacs

Meeting Description

Synthetic Biology – the design of increasingly complex biological systems according to principles recruited from classical engineering disciplines – is undergoing a rapid expansion from its founding fields – such as the design of biological circuits – into the broad realm of academic and industrial bioengineering. Driven for example by amazing developments in DNA synthesis and assembly, genome engineering, computer-aided design resources, and the ever increasing arsenal of parts and tools, more complex designs are implemented up to the full re-design of eukaryotic chromosomes. On the other hand, crucial developments for systems design, such as minimal and orthogonal systems and in vitro designs, are taking place. The rapid conceptual and technological advance is also reflected in increasing reception of the field in industry and the emergence of major centers of academically driven research and development and entrepreneurship.

The 2015 Gordon Research Conference on Synthetic Biology will present cutting-edge research from this rapidly developing field and provide an in-depth discussion forum among practitioners from academia and industry of the various fields contributing to Synthetic Biology. We will work towards identifying crucial scientific, but also societal challenges for the coming years, and towards laying the basis for future developments and consolidation of the field towards fulfilling the envisaged – and ambitious – goals. In addition to bringing together a collection of investigators who are at the forefront of their field, this conference offers excellent opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. The collegial atmosphere, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnabling Technologies
Discussion Leader: Timothy Lu (Massachusetts Institute of Technology, USA)
7:40 pm - 8:20 pmEran Segal (Weizmann Institute of Science, Israel)
"Unraveling Principles of Gene Regulation Using Massively Parallel Measurements of Synthetically Designed Sequences"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMustafa Khammash (ETH Zurich, Switzerland)
"Cybergenetics: Circuits and Systems for the Precise Control of Living Cells"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmComputational and Evolutionary Design
Discussion Leader: Andrew Ellington (University of Texas, Austin, USA)
9:00 am - 9:40 amDouglas Densmore (Boston University, USA)
"Fluigi: Design Environment for the Automated Design, Fabrication, and Operation of Synthetic Biological Microfluidics"
9:40 am - 9:55 amDiscussion
9:55 am - 10:20 amCoffee Break
10:20 am - 11:00 amJoerg Stelling (ETH Zurich, Switzerland)
"Multiscale Models for Synthetic Circuit Design"
11:00 am - 11:15 amDiscussion
11:15 am - 11:55 amThomas Ward (University of Basel, Switzerland)
"Artificial Metalloenzymes for Synthetic Biology: Challenges and Opportunities"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmJeffrey Sampson (Agilent Technologies, USA)
"Advanced Oligonucleotide Libraries (OLS): Enabling Research in Synthetic Biology"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnvironmental Engineering
Discussion Leader: Vitor Martins Dos Santos (Wageningen University, The Netherlands)
7:30 pm - 8:10 pmJune Medford (Colorado State University, USA)
"Designing Multicellular Synthetic Biology Traits in Plants"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmTobias Erb (Max-Planck-Institute for Terrestrial Microbiology, Germany)
"Exploring and Engineering Carboxylating Enzymes and Pathways: Towards Synthetic CO2-Fixation"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMammalian Cell Engineering
Discussion Leader: Ahmad Khalil (Boston University / Wyss Institute, Harvard University, USA)
9:00 am - 9:40 amPeng Yin (Harvard University, USA)
"DNA Powered Microscopy"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amDavid Liu (Harvard University, USA)
"Continuous Evolution of Proteins for Synthetic Biology and Next-Generation Therapeutic Applications"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmTanja Kortemme (University of California, San Francisco, USA)
"Computational Design of New Molecular and Cellular Functions"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenome Engineering
Discussion Leader: Ralf Wagner (University of Regensburg, Germany)
7:30 pm - 8:10 pmAndrew Ellington (University of Texas, Austin, USA)
"Directed Evolution of Synthetic Circuits"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmAnke Becker (Loewe Center for Synthetic Microbiology, Germany)
"Engineering of Alpha-Rhizobial Genomes"
9:10 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSystems Engineering for Industrial Applications
Discussion Leader: Daniel Dwyer (University of Maryland, College Park, USA)
9:00 am - 9:40 amEriko Takano (University of Manchester, United Kingdom)
"Next Steps Towards Synthetic Biology for Pharmaceutical and Fine Chemical Production"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amVitor Martins Dos Santos (Wageningen University, The Netherlands)
"Re-Programming Microbes for Bespoke Biocatalysis"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmDrew Endy (Stanford Bioengineering, USA)
"Why ‘Industrialization' Is the Wrong Metaphor for Synthetic Biology"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSystems Engineering and Chassis
Discussion Leader: Vitor Pinheiro (University College London, United Kingdom)
7:30 pm - 8:10 pmJay Keasling (University of California, Berkeley, USA)
"Engineering Microbes for Production of Drugs, Fuels, and Chemicals"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmMattheos Koffas (Rensselaer Polytechnic Institute, USA)
"Engineering Static and Dynamic Control of Malonyl CoA Derived Fluxes"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell-Free Biology
Discussion Leader: Roman Jerala (National Institute of Chemistry, Slovenia)
9:00 am - 9:40 amRoy Bar-Ziv (Weitzmann Institute of Science, Israel)
"Cell-Free Synthetic Biology on a Chip"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amVincent Noireaux (University of Minnesota, USA)
"Cell-Free Transcription-Translation: From Gene Circuits to Self-Assembly in a Test Tube"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmTakuya Ueda (The University of Tokyo, Japan)
"The PURE System as a Platform Technology for Synthetic Biology"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmOrthogonal Systems
Discussion Leader: Dieter Soell (Yale University, USA)
5:30 pm - 6:10 pmMichael Jewett (Northwestern University, USA)
"Engineering Synthetic Ribosomes"
6:10 pm - 6:30 pmDiscussion
6:30 pm - 7:10 pmFloyd Romesberg (The Scripps Research Institute, USA)
"A Semi-Synthetic Organism with an Expanded Genetic Alphabet"
7:10 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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