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Cell Biology of Metals (GRS)
Gordon Research Seminar

The Role of Metal Ions in Health and Disease

Dates

July 22-23, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Kevin J. Waldron & Clorissa L. Washington-Hughes

Meeting Description

The Gordon Research Seminar on Cell Biology of Metals is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this inaugural GRS meeting is on the various roles of metal ions in health and disease. The sessions will focus on (i) the diverse roles of essential metal ions and the importance of metal homeostasis mechanisms in mammalian physiology, with a focus on metal-related disorders caused by homeostatic breakdown, and (ii) the battle for metal ions at the host-pathogen interface.

Related Meeting

This GRS was held in conjunction with the "Cell Biology of Metals" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Metals in Host-Fungal Interactions
Discussion Leader: Karrera Djoko (The University of Queensland, Australia)
3:45 pm - 4:05 pmValeria Culotta (Johns Hopkins University, USA)
"Winning the Battle with Metals and ROS: Tales of a Successful Fungal Pathogen"
4:05 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmEdward Culbertson (Johns Hopkins School of Public Health, USA)
"Copper, Iron and Ceruloplasmin During Fungal Infection"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetals in Host-Bacterial Interactions
Discussion Leader: Duncan Wilson (University of Aberdeen, United Kingdom)
7:30 pm - 7:50 pmJules Stephan (Massachusetts Institute of Technology, USA)
"Methionine Oxidation Increases the Protease Sensitivity of Calprotectin by Altering Its Oligomeric State"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmKyle Grim (University of Illinois at Urbana-Champaign, USA)
"The Metallophore Staphylopine Enables Staphylococcus aureus to Compete with the Host for Zinc and Overcome Nutritional Immunity"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmVictoria Pederick (The University of Adelaide, Australia)
"The Role of Pht Proteins in Pneumococcal Zinc Acquisition"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJiefei Wang (Indiana University Bloomington, USA)
"The Response of Acinetobacter baumannii to Human-Mediated Zinc Starvation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJulia Quintana (Worcester Polytechnic Institute, USA)
"Dissecting Copper Distribution Networks in Pseudomonas aeruginosa"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMaria Alessandra Martini (Durham University, United Kingdom)
"Modelling a Network of Metal Sensors"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMetals in Human Disease
Discussion Leader: Edward Culbertson (Johns Hopkins School of Public Health, USA)
9:00 am - 9:20 amVinit Shanbhag (University of Missouri, USA)
"Role for ATP7A Copper Transporter in Cisplatin Resistance, Tumorigenesis and Metastasis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSubha Bakthavatsalam (Duke University, USA)
"Copper Prochelator as Prodrug for Prostate Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSayani Das (Tata Institute of Fundamental Research, India)
"Mn(II) Sensor Diaries: Stumbling upon a Hg(II) Sensor and What We Learn from It"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amLisa Cunden (Massachusetts Institute of Technology, USA)
"Modulation of the Zn(II)-Binding and Functional Roles of S100A7 Through Its Intramolecular Disulfide Bonds"
10:25 am - 10:30 amDiscussion
10:30 am - 10:50 amViktoria Desiree Paul (Philipps-Universität Marburg, Germany)
"With a Little Help from My Friends: The Human YAE1D1-ORAOV1 Adaptor Complex Recruits the CIA Machinery to Facilitate Fe-S Cluster Incorporation into ABCE1"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmKeynote Session: Metals in Eukaryotic Physiology
Discussion Leader: Vinit Shanbhag (University of Missouri, USA)
1:30 pm - 1:50 pmSven Freibert (Philipps-Universität Marburg, Germany)
"Structural and Functional Insights into Mitochondrial Fe/S Cluster Synthesis"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmDennis Thiele (Duke University School of Medicine, USA)
"A Winding Journey from Yeast to Mammals Guided by Metals"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1 R13 DK113725-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. government.
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