Gordon Research Conferences
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Conference Program
 
Phagocytes
June 9-14, 2013
Waterville Valley Resort
Waterville Valley, NH
Chair:
Lee-Ann H. Allen

Vice Chair:
Paul Kubes

Related Meeting Information
The Phagocytes Gordon Research Conference was held in conjunction with the Phagocytes Gordon Research Seminar. Please refer to the Phagocytes GRS web page for more information.

The 2013 Phagocytes Gordon Conference will bring together scientists from around the world to discuss the most recent advances in the field. Expert invited speakers will present their latest unpublished research related to the many facets of phagocyte biology. Featured topics will include macrophage functional genomics, mathematical modeling and in vivo analysis of neutrophil polarity and migration, host-pathogen interactions, inflammasomes, phagocytosis and autophagy, functional and phenotypic plasticity of phagocytes in the tumor microenvironment and the brain, and exciting advances in our understanding of phagocyte interactions with and effect on other cell types during infection, inflammation and sepsis. The program is designed to encourage vigorous discussion and the free exchange of ideas. Thus, each scientific session will be chaired by a prominent researcher who will highlight recent progress and knowledge gaps related to each topic, and guide subsequent discussion. As participation of junior scientists is a key goal of the meeting, the conference will also include two interactive sessions for presentation of ~90 posters, and additional speakers will be chosen from among the submitted abstracts. The collegial atmosphere of this conference is exemplified by the shared meals, and the substantial time provided for informal gatherings in the afternoons and evenings to further promote interactions between attendees at all levels. The overall environment is therefore designed to provide multiple opportunities for learning and for the development of relationships and collaborations.

To facilitate the participation of students and postdoctoral fellows, the conference will be preceded by a Gordon Research Seminar (GRS). The Phagocytes GRS is planned by and for trainees, and provides an opportunity for our future leaders to present their research via seminars and posters in a supportive and interactive environment. The GRS has been well received and adds substantial value to the Gordon Research Conference experience for these junior investigators.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:55 pmChair's Welcome and Introductory Remarks by Lee-Ann Allen (University of Iowa)
7:55 pm - 9:30 pmKeynote Lecture: Macrophage Functional Genomics
7:55 pm - 8:15 pmDiscussion Leader: David Mosser (University of Maryland)
8:15 pm - 9:05 pmDavid Hume (University of Edinburgh)
"Macrophage Functional Genomics"
9:05 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBacterial Pathogens and the Host Response
Discussion Leader: Frank DeLeo (NIH/NIAID)
9:05 am - 9:30 amFrank DeLeo (NIH/NIAID)
"Manipulation of neutrophil function by Staphylococcus aureus"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amShort talk: Alison Criss (UVA)
"Survival of Neisseria gonorrhoeae after primary human neutrophil challenge"
9:55 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:55 amJason Carlyon (Virginia Commonwealth University)
"Interior decorating: Anaplasma phagocytophilum remodeling of its host-derived vacuole"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amAlexander Hoffmann (UCSD)
"Dynamics and Combinatorics in the cellular response to pathogens"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmJeff Schorey (University of Notre Dame)
"Modulation of leukoycte migration and activation by exosomes released from mycobacteria-infected macrophages"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPhagocytes in the Tumor Microenvironment
Discussion Leader: Dianne Cox (Albert Einstein/Yeshiva U.)
7:35 pm - 8:00 pmMikael Pittet (Harvard)
"Origins of tumor-associated macrophages and neutrophils"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmLisa Coussens (Oregon Health and Science U.)
"Reprogramming immune responses in solid tumors as a therapeutic strategy"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmShort talk: Julian Gomez-Cambronero (Wright State U.)
"PLD small molecule inhibitors at the crossroads of inflammation and cancer"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort talk: Ya-Ping Ko (Tamu Health Science Center)
"Phagocytosis escape by a bacterial protein that connects Complement and Coagulation proteins at the bacterial surface"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAltered States of Phagocytes in Health and Disease
Discussion Leader: Joel Swanson (University of Michigan)
9:05 am - 9:30 amV. Hugh Perry (Southampton General Hospital)
"The impact of systemic inflammation on the innate immune cells of the brain in health and disease"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amShort talk: Douglas Kuhns (Saic-Frederick, Inc.)
"Cytoskeletal abnormalities and neutrophil dysfunction"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:15 am - 10:40 amAndrea Tenner (U. of California, Irvine)
"Complement mediated inflammation in the brain: new targets for preventing Alzheimer's Disease?"
10:40 am - 10:55 amDiscussion
10:55 am - 11:20 amAkira Takashima (University of Toledo)
"Neutrophil-dendritic cell hybrid - a unique leukocyte population with dual properties of professional phagocytes and antigen-presenting cells"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmMary Dinauer (Washington U.)
"Turning off inflammation: NADPH oxidase and crosstalk with innate lymphocytes"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort talk: Mawadda Alnaeeli (Ohio U., Zanesville campus)
"Erythropoetin: a novel regulator of macrophage recruitment and polarization during obesity-induced white adipose tissue inflammation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmThe Expanding Role of Neutrophils in Immunity and Inflammation
Discussion Leader: Mary Dinauer (Washington U.)
7:35 pm - 8:00 pmJessica Moreland (U. of Iowa)
"Neutrophil priming in inflammatory bowel disease: a benefit or detriment to the host?"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmLeo Koenderman (U. of Utrecht)
"Functional compartmentalization of neutrophils: identification of separate subsets of cytotoxic and immune suppressive cells"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMarco Cassatella (U. of Verona)
"Advances in neutrophil biology and immunity"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Migration and Polarization
Discussion Leader: Paul Kubes (U. of Calgary)
9:05 am - 9:30 amSussan Nourshargh (Queen Mary University)
"Neutrophil transmigration dynamics in vivo: characterization and implications to tissue damage"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amShort talk: Mallary Greenlee (U. of Iowa)
"Staphylococcus aureus evades neutrophil and macrophage-mediated immune responses"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:15 am - 10:40 amLani Wu (U. Texas Southwestern, Dallas)
"Reverse engineering of information flow in neutrophil polarity networks"
10:40 am - 10:55 amDiscussion
10:55 am - 11:20 amMinsoo Kim (U. of Rochester)
"Local inflammatory cues generated by neutrophil migration"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmAnna Huttenlocker (U. of Wisconsin-Madison)
"Imaging leukoycte migration and inflammation in vivo using zebrafish"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort talk: Payal Mehta (Medimmune LLC/AstraZeneca)
"LC3-associated phagocytosis mediates IFN-alpha secretion in response to DNA-immune complexes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNew Mechanisms of Regulation
Discussion Leader: Michelle Lennartz (Albany Medical College)
7:35 pm - 8:00 pmRobert Munford (NIH/NIAID)
"TLR signaling and macrophage metabolism"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmVeronique Witko-Sarsat (Inserm, Cochin Institute, Paris)
"Role of PCNA in neutrophil survival"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmCarmen Alvarez-Dominguez (IFIMAV)
"Listeria phagosomes and thier use as vaccines and signaling platforms"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammasomes
Discussion Leader: Lynda Stuart (Massachusetts General Hospital)
9:05 am - 9:30 amFayyaz Sutterwala (U. of Iowa)
"Inflammasome mediated regulation of Th17 immune responses"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amShort talk: Christine Becker (Massachusetts General Hospital)
"A phagosome-associated Rab GTPase that interacts with caspase-1 and is important for regulating trafficking in the innate immune system"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:15 am - 10:40 amMaya Saleh (McGill U.)
"Cross regulation of apoptosis and inflammasomes"
10:40 am - 10:55 amDiscussion
10:55 am - 11:20 amJeff Cox (U.of California, San Francisco)
"The ubiquitin ligase PARKIN is required for autophagy and host resistance to intracellular pathogens"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmJohn Kehrl (NIH/NIAID)
"How autophagy augments and limits inflammasome activity"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort talk: Edward Miao (UNC Chapel Hill)
"Noncanonical inflammasome activation of caspase-11 protects against cytosolic bacteria"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmPhagocytosis and Phagosomes
Discussion Leader: William Nauseef (U.of Iowa)
7:35 pm - 8:00 pmSergio Grinstein (Hospital for Sick Children, U. of Toronto)
"Regulation of actin polymerization during phagocytosis"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmNicolas Demaurex (U. of Geneva)
"STIM1-mediated calcium signaling at the endoplasmic reticulum-phagosome interface"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmSergio Catz (Scripps Research Institute)
"Regulation of vesicular trafficking and fusion by Rab effectors and why it matters to the neutrophil"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI106065-01from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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