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Intrinsically Disordered Proteins (GRS)
Gordon Research Seminar

Fundamental Characteristics and Approaches to Understand the Biological Functions of IDPs

Dates

July 5-6, 2014

Location

Stonehill College
Easton, MA

Organizers

Chair:
K. Aurelia Ball

Associate Chair:
Charles Ravarani

Meeting Description

The Gordon Research Seminar on Intrinsically Disordered Proteins is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to introduce the topic of IDPs to those just entering the field while motivating interest in key areas of IDP research. Topics covered will include: (i) what characteristics define an IDP, (ii) what experimental and computational tools can be used to study IDPs, and (iii) what roles IDPs play in vivo. The GRS will also include a career development session featuring a panel of scientists at different points in their career path who will offer career advice and answer questions on the academic job search from a variety of perspectives.

Related Meeting

This GRS was held in conjunction with the "Intrinsically Disordered Proteins" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmProtein Disorder and the Structure/Function Paradigm
Discussion Leaders: Keith Dunker (Indiana University School of Medicine) and Lisette Fred (Georgetown University)
3:45 pm - 4:00 pm Ofrah Faust (The Hebrew University of Jerusalem)
"A Role for a Disordered Domain in Regulating Protein Oligomerization and Stability"
4:00 pm - 4:05 pm Discussion
4:05 pm - 4:20 pm Mihaly Varadi (VIB Flemish Institute for Biotechnology)
"Approaching the Function of IDPs by Structural Ensembles"
4:20 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Techniques to Identify and Characterize IDPs
Discussion Leaders: Jane Dyson (The Scripps Research Institute) and Peter Chung (University of California, Santa Barbara)
7:30 pm - 7:50 pm Sarah Shammas (University of Cambridge)
"Speed-Dating in the KIX System: Kinetics and Mechanism of Coupled Folding and Binding Reactions"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Tayler Croom-Perez (Pennsylvania State University)
"Expanding the Functional Proteome of an RNA Virus by Post-Translational Modification of a Protein Containing an Intrinsically Disordered Domain"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jouhyun Jeon (University of Toronto)
"Identifying Anti-Proliferative Peptides Through High-Throughput Screening of Disordered Human Peptidome"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Kiersten Ruff (Washington University in St. Louis)
"Mechanistic Insights into Polyglutamine Aggregation in the Context of Flanking Sequences from Huntington"
9:20 pm - 9:30 pm Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amHow IDPs Function in a Cellular Environment
Discussion Leaders: Sonia Longhi (CNRS / Universities Aix-Marseille I and II) and Justine Charon (INRA-France)
9:00 am - 9:20 am Assaf Biran (Weizmann Institute of Science)
"Regulation of Ubiquitin Independent Proteasomal Degradation of Intrinsically Disordered Proteins"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Andrea Soranno (University of Zürich)
"Single-Molecule Spectroscopy Reveals Polymer Effects of Disordered Proteins in Crowded Environments"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Wade Borcherds (University of South Florida)
"Disorder and Fractional Helicity of p53 Determine p53-Mdm2 Binding Affinity and Are Fine Tuned for Correct Cellular Signaling"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Sanghita Banerjee (Indian Statistical Institute)
"Unstructured Housekeeping Proteins and Tissue Specific Interactions"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCareer Panel
Discussion Leader: Rebecca Berlow (The Scripps Research Institute)
Featuring:
  • Simon Alberti (Max Planck Institute of Molecular Cell Biology and Genetics)
  • Doug Barrick (Johns Hopkins University)
  • Tanja Mittag (St. Jude Children's Research Hospital)
  • Matthew Gage (Northern Arizona University)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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